That's what UC San Francisco medical student Joshua Lang wrote in his piece, With Summer Coming, Can the Zika Virus Be Contained?, published April 14 in The New Yorker.
Meanwhile, at UC Davis, plans are underway for a public "Zika Public Awareness Symposium," set Thursday, May 26 from 6:30 to 8:30 p.m. in Room 1001 of Giedt Hall.
"It is very important that students and the public-at-large learn how to prevent a possible Zika epidemic as this is the first virus known to be transmitted both sexually and by mosquitoes," said coordinator Walter Leal, a chemical ecologist and professor in the UC Davis Department of Molecular and Cellular Biology. Leal, who collaborates with fellow mosquito researchers in his native Brazil, is the co-chair of the International Congress of Entomology (ICE) meeting, to take place Sept. 25-30, 2016 in Orlando, Fla.
"This symposium is important to host because Zika is a rapidly spreading across the globe so people need to be informed," said Amarita Singh, one of the 18 students organizing the symposium. "Recent studies have shown that this particular virus not only affects pregnant women, but is a threat to all. Since there is no vaccine or medication, it is better to educate now to help prevention."
"I became more aware of the disease when Professor Leal began to discuss it in our biochemistry class, which is what originally sparked my interest," Singh said. "After learning about how dangerous the disease was and the discovery of the first case in Yolo County, I decided to take the opportunity in organizing the symposium."
Singh added: "It is incredible how much research has been done on Zika virus in the short amount of time. I am hopeful that in the near future that a vaccine will be developed, but until then we should do everything in our power to prevent this horrible virus from spreading. My concerns are that people may not be well informed which allows the virus to spread even more rapidly."
Said James Warwick, also one of the student organizers: "I think one of the scariest things about Zika in the United States is the lack of public knowledge about it. The scientific community needs to research the virus and develop a vaccine, but can't without funding. And without public pressure, securing funding is going to be slow. Also, the sheer suddenness in which Zika has burst onto the global scene has left both scientific research and public knowledge behind. That is why we are hosting the symposium, to bring the public up to speed, update them on the current research, and to give them the knowledge they need to protect themselves against transmission. As a byproduct, public awareness will increase public pressure to get the world on the right track to stop the spread of Zika."
"The virus itself is extremely alarming," Warwick said. "It can cause extreme neurological and immunological defects, as we see in babies born to infected mothers. But the direct hosts' symptoms usually consist only of temporary pain, rashes, fever, and the like; and only one in four or so people infected with Zika become symptomatic. So there is a very real possibility that a person could be infected, not be aware of it, and potentially pass on the undetected infection to sexual partners or their children. This is made all the more plausible by the fact that many people have never heard of Zika."
A flier (below) distributed at the campuswide UC Davis Picnic Day noted that the "Zika virus is a risk to all of us, not just to pregnant women." At the May 26th symposium, folks will "learn the symptoms and learn the facts and science about Zika and how you can protect yourself from this disease."
The scientific-based symposium will include "expert panels and speakers throughout the United States and the world, including those working on the front lines of the Zika epidemic." Speakers will be announced soon.
Attendance to the symposium is free, but due to limited space, those planning to attend are asked to RSVP to firstname.lastname@example.org
Native Brazilian Walter Leal, chemical ecologist and professor in the UC Davis Department of Molecular and Cellular Biology, is there.
So is the mosquito.
At the symposium today, Constancia Ayres, research coordinator of the Oswaldo Cruz Foundation (Centro de Pesquisa Aggeu Magalhaes/FIOCRUZ, considered one of the oldest and most prestigious scientific research institutes in South America), reported that the common southern house mosquito, Culex quinquefasciatus, may be a potential vector of the Zika virus.
Studies in the Ayres lab confirmed that Culex quinquefasciatus infected with Zika (isolated from local patients) showed high transmission rate (as determined by virus replication in the salivary glands).
Of course, these studies were done in the lab, not the field, and this is the beginning of the research.
We asked medical entomologist William Reisen, editor of the Journal of Medical Entomology, and professor emeritus, Department of Pathology, Microbiology and Immunology, UC Davis School of Veterinary Medicine, about this.
"In California less than 3 percent of the Culex including Cx. quinquefasciatus have been found to feed on humans, even in cities like Los Angeles, where humans are the most numerous host," Reisen said in an email. "Therefore, even if they are susceptible to infection, the probability of a female feeding on humans to acquire and then refeed on humans to transmit would be 0.03 x 0.03 = 0.0009 or a rare event indeed. That said, there are areas of the world where quinquefasciatus feeds predominantly on humans in domestic settings. (See his research paper, Host Selection Patterns of Some Pakistan Mosquitoes (U.S. National Library of Medicine, National Institutes of Health).
In his research paper on Pakistan mosquitoes, Reisen mentions Culex pipiens fatigans, now known as Culex quinquefasciatus. Its feeding patterns "varied opportunistically with host availability," he wrote in the abstract. Resting in cattle sheds during the winter, it "fed on birds and bovids, changing to man and bovids during the spring and then to man and birds during summer."
Medical entomologist Thomas Scott, distinguished professor of entomology (now emeritus) of the UC Davis Department of Entomology and Nematology, is a global authority on Aedes aegypti, which transmits dengue, yellow fever, chikungunya and the Zika viruses.
"Vector competence studies in the lab is valuable information, but before we come to the conclusion that Culex quinquefasciatus is an important contributor to transmission of Zika virus, the lab results would need to be confirmed," Scott told us. "Other laboratories and appropriate field studies would need to be carried out in areas where Zika virus is being transmitted to confirm that this species is naturally infected and is regularly biting people. Although it is a potentially important discovery that would change they way we think about Zika virus transmission, it would be wise to carefully explore all of the details necessary to incriminate a mosquito vector before coming to a strong conclusion."
UC Davis medical entomologist Anthony Cornel of the Kearney Agricultural Research and Extension Center and UC Davis Department of Entomology and Nematology, weighed in: "I have to examine the vector competence data carefully to determine its infectivity dose relative to Aedes aegypti. If Culex quinquefasciatus does play an additional role in transmission then it would be of even greater concern because the threat of autochthonous transmission will occur in areas other than where Aedes aegypti is found in California. Culex quinquefasciatus also feed on people but do so at dusk and at night."
"Brazil could be facing a greater fight against the zika virus than previously feared as researchers investigate whether the common mosquito is transmitting the disease," Moraes wrote in the article, headlined "Brazilian Experts Investigate if 'Common Mosquito' is Transmitting Zika Virus."
"The Aedes aegypti species of mosquito was thought to be solely responsible for spreading the virus," Moraes pointed out. "But scientists are now studying whether the Culex mosquito--the variety (species) most commonly found in Brazil--could also be passing on the infection."
Constancia Ayres was quoted as saying: "This may be the reason for the virus replicating faster. The interaction of the mosquito with the virus may explain the epidemiological profile of disease transmission.”
Meanwhile, the headlines continue as research proceeds.
"The concern is that the Culex mosquito--which is 20 times more prevalent than the Aedes variety in Brazil-- might also play some role in the rapid spread of these viruses," Outbreak News Today noted. "Researchers hope to have some answers in a few weeks,"
Valor.com.br is hot on the story as well. Reporter Marina Hawk emphasized that the work was done in the lab, but field collection is underway.
If you're nurturing a passionflower vine (Passiflora), you've probably seen "The Butterfly Ballet."'
The Gulf Fritillaries (Agraulis vanillae), orangish-reddish butterflies with silver-spangled wings, stay close to Passiflora, their host plant. It's the circle of life. The males patrol for females, find them, and mate. The females lay eggs, eggs become caterpillars, caterpillars become chrysalids. The adults emerge, and the Butterfly Ballet begins anew.
The Gulf Frits have no borders or boundaries, nor should they, as they shoot and soar over fences and gates. Theirs is not a gated community.
The "no-borders, no-boundaries" scenario reminds us of the upcoming conference of the International Congress of Entomology (ICE), to take place Sept. 25-30, 2016 in Orlando, Fla. The theme: "Entomology Without Borders."
The conference, expected to be the world's largest gathering of entomologists--some 7,000 are expected to attend--is chaired by chemical ecologist Walter Leal, professor in the UC Davis Department of Molecular and Cellular Biology and former chair of the UC Davis Department of Entomology, and vegetable research entomologist Alvin Simmons of USDA/ARS. They have lined up prestigious speakers, including two Nobel Prize winners: Peter Agre (Nobel Laureate, 2003 and Jules Hoffmann (Nobel Laureate, 2011). Among the other speakers is one of Cuba's leading entomologists, Juan Andrés Bisset, head of the Vector Control Department at the Pedro Kouri Institute of Tropical Medicine and an advisor to the Cuban Public Health Ministry.
Other UC Davis connections? Two of the plenary speakers are James R. Carey, distinguished professor of entomology at UC Davis, and Arizona State University Provost Robert E. Page Jr., former professor and chair of the UC Davis Department of Entomology.
ICE is held once every four years in different countries around the world. Next year it will be held simultaneously with the annual meetings of the Entomological Society of America, the Entomological Society of Canada, and other organizations. For more information, access the ICE website at http://ice2016orlando.org.
Meanwhile, think of "Gulf Frits Without Gulfs" or "Bugs Without Borders" closely linked to "Entomology Without Borders."
Professor Walter Leal of the University of California, Davis, is co-chairing the 2016 International Congress of Entomology (ICE) conference, themed "Entomology Without Borders," to be held Sept. 25-30 in Orlando, Fla. Some 7000 entomologists from all over the world are expected to attend.
But he himself could be considered an "entomologist without borders."
Leal has achieved international, national and state recognition and stature for his work in insect communication and his leadership achievements.
Leal, a professor in the UC Davis Department of Molecular and Cellular Biology, and former professor and chair of the UC Davis Department of Entomology. was just named an honorary fellow of the Royal Society of Entomology at a conference held in Dublin, Ireland. He was recognized for his lifetime contributions to entomological science at the global level. He earlier was named a fellow of the society.
And, on Oct. 13, Leal will be inducted as a fellow of the California Academy of Sciences, "a governing group of more than 400 distinguished scientists who have made notable contributions to one or more of the natural sciences." Leal joins Lynne A. Isbell, a UC Davis professor in the Department of Anthropology, as the two UC Davis inductees this year.
Leal, born in Brazil and educated in Brazil and Japan, joined the UC Davis faculty in 2000. He is a fellow of the American Association for the Advancement of Science and the Entomological Society of America and is a member of the Brazilian Academy of Sciences.
A chemical ecologist, Leal is a past president of the International Society of Chemical Ecology and received the silver, medal, the society's highest honor, in 2012. He was the first non-Japanese scientist to earn tenure in the Japan Ministry of Agriculture.
Leal investigates the molecular basis of olfaction in insects and insect chemical communication. (See the Leal lab's work on DEET in Entomology Today.) He researches environmentally friendly alternatives to control insects of medical importance, and also targets agricultural pests. (See research projects.)
Leal is truly an entomologist without borders. In addition to his many global accomplishments and achievements, he is a citizen of the world, speaking his native Portuguese, as well as Japanese, and English.
Chemical ecologist Yuko Ishida of Toyama, Japan, a former UC Davis post-doctoral researcher who shared the same lab--and the same bench--in Briggs Hall that Duffey did, is the lead co-author of a cover story recently published in the Proceedings of the National Academy of Sciences (PNAS) about an invasive species of millipede that secrets hydrogen cyanide as a defensive mechanism. (See research paper)
Ishida and Duffey never met but they shared a love of science and chemical ecology, in addition to the same lab.
At the time of his death, Duffey was a professor and vice chair of the UC Davis Department of Entomology. When chemical ecologist/professor Walter Leal joined the UC Davis Department of Entomology faculty in 2000, he occupied the former labs of professors Duffey and Susumu Maeda (1950-1998) and memoralized their lives and work by naming his lab the “Honorary Maeda-Duffey lab.”
Ishida worked in the Honorary Maeda-Duffey lab from May 2001 to November 2007 at UC Davis.
“Yuko loves to tackle challenging problems and he is well prepared to solve them,” said Leal, former chair of the UC Davis Department of Entomology and now with the UC Davis Department of Molecular and Cellular Biology.
Ishida also photographed the millipede, found in southern Japan, for the PNAS cover.
The four scientists all work at the Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, and are affiliated with the Asano Active Enzyme Molecule Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Toyama.
“To discover more efficient and stable HNLs, we focused on the invasive cyanogenic millipede as a bioresource,” the scientists wrote. “The HNL identified from the millipede showed not only the highest specific activity toward benzaldehyde among known HNLs, including the almond HNL in industrial use, along with wide temperature and pH stabilities, but also high enantioselectivity in the synthesis of various cyanohydrins. These properties make it suitable as an industrial biocatalyst. Arthropods are likely to be valuable sources of potential biocatalysts for the next generation of industrial biotechnology.”
“There followed several papers on the biochemistry of HCN production and the production of other defensive compounds in these interesting animals,” they wrote. “After arriving at UC Davis, Sean began a long series of brilliant studies on the chemical mechanisms used by plants to fend off attack by insects and various pathogens. This work centered on resistance in tomatoes, and over the years he collaborated with numerous students and colleagues. Studies analyzed the role of numerous chemicals produced by plants including tomatine, proteinase inhibitors, and various plant oxidative enzymes. Recent studies had included analyses of induced defenses and the interactions of chemicals with the biological agents such as parasitoids and baculoviruses used in various IPM and biological control programs.”
“A constant theme and frequently emphasized message in Sean's work was the fact that chemical-biological interactions were rarely simple and straightforward,” they wrote. “He stressed that in order to understand plant-insect interactions, for example, it was necessary to understand the interactions among plant chemicals, the overall characteristics of the insect's diet, the physiological state of the insect, and the modifiable characteristics of plant and insect. Chemical and biological context and chemical mixture were seen as critical determinants of biological activity; a simple view that natural products functioned merely as "toxins" or isolated defensive factors was often misleading.”
Carey, Dingle and Ullman praised Duffey's "truly interdisciplinary research that included several joint projects with members of the Entomology Department and also with colleagues in the departments of Nematology Ecology and Plant Pathology. We all experienced Sean insisting over and over that interactions are not simple and that one must understand the chemistry, the physiology, and the ecology to really understand interactions between plants, insects, and their pathogens. Sean's legacy is an outstanding record of how to go about studying plant-insect interactions, not just the gathering of data on interactions that occur.”
The legacy continues...