- Author: Kathy Keatley Garvey
As mentioned earlier, two members of the Academic Senate's winners' circle are UC Davis Distinguished Professor Walter Leal of the Department of Molecular and Cellular Biology (and former professor and chair of the UC Davis Department of Entomology), and Professor Louie Yang of the Department of Entomology and Nematology (ENT).
Leal won the Distinguished Faculty Research Award (see Feb. 22 Bug Squad blog) and Yang won a Distinguished Teaching Award, undergraduate category (see Feb. 26 Bug Squad blog). UC Davis Distinguished Professor Bruce Hammock of ENT nominated Leal, while Joanna Chiu, professor and chair of ENT, nominated Yang.
The awards reception is Monday, May 13; more information is pending. "In all, 15 faculty members have received awards from the two groups at UC Davis," UC Davis Dateline reports. (See list of the recipients.)
Leal is the first UC Davis faculty member to win all three of the Academic Senate's most coveted awards: in research, teaching, and public service. In 2020, the Academic Senate awarded him the Distinguished Teaching Award for Undergraduate Teaching, and in 2022 Distinguished Scholarly Public Service Award.
“Dr. Leal is an internationally recognized entomologist and a world leader in his field for his groundbreaking and transformative research in insect olfaction and chemical ecology,” Hammock wrote. "Walter is truly a renaissance man. "He chaired our entomology department from 2006 to 2008, and under his tenure, our department was ranked No. 1 in the country. I've long admired (1) his rigorous fundamental research programs supported by National Science Foundation, National Institutes of Health, and the U.S. Department of Food and Agriculture, and other agencies, (2) how he tackles and solves multiple challenging problems in insect olfaction and chemical ecology, (3) his grasp of how to organize and moderate highly successful worldwide research webinars (4) his generosity in helping other succeed and (4) his finely honed sense of humor."
Wrote Chiu: "I have watched him (Professor Yang) engage, inspire, and challenge his students, fostering creative and critical thinking like no one else I've ever seen. We deeply appreciate and admire his innovative and inclusive teaching, his exemplary work ethic, his welcoming demeanor, his dedication to his students, and his nationally recognized ecology expertise. Louie has received many well-deserved teaching and mentoring awards for his teaching contributions on and off campus.”
Of special note, too, is the James H. Meyer Distinguished Achievement Award, given annually to a member of the Academic Federation for "a distinguished record in research, teaching, and/or public service." This year the award went to Kirsten Gilardi, director of Karen C. Drayer Wildlife Health Center, and a health sciences clinical professor of Medicine and Epidemiology, School of Veterinary Medicine.
Wrote Dateline: "Health Sciences Clinical Professor Kirsten Gilardi has been part of the UC Davis Community since 1989. She is currently the director of the Karen C. Drayer Wildlife Health Center, a research, service and teaching center of excellence. In 2005, she founded the California Lost Fishing Gear Recovery Program, which hires experienced commercial scuba divers to remove gear and other marine debris from near-shore waters in a safe and environmentally sensitive manner. This program continues to help reduce the potential impact of losing fishing gear and marine debris on living marine resources and underwater habitat. Beyond her significant accomplishments in her field, her colleagues around the world highlight her passion for her position at UC Davis 'that expects her to protect wild animals and wild places.'"
Check out the Dateline website which includes a 2013 image of Gilardi with a silverback gorilla (image courtesy of Sandy Buckey.)
They all do UC Davis proud!
- Author: Kathy Keatley Garvey
Congratulations to UC Davis distinguished professor Walter Leal, the recipient of the Academic Senate's highly competitive 2024 Distinguished Faculty Research Award.
That makes three. Good things come in threes.
Leal is the first UC Davis faculty member to win all three of the Academic Senate's most coveted awards: in research, teaching, and public service. In 2020, the Academic Senate awarded him the Distinguished Teaching Award for Undergraduate Teaching, and in 2022 Distinguished Scholarly Public Service Award.
Leal, a member of the Department of Molecular and Cellular Biology since 2013 and former professor and chair of the Department of Entomology, commented: "Faculty at land-grant universities, like the University of California, have three hats labeled Teaching, Service, and Research. A significant challenge is to budget time to wear them equally and avoid the temptation to emphasize one part of the job over others. It is gratifying to be recognized by my peers as excelling in all areas. The Academic Senate Faculty Distinguished Research Award is particularly humbling because more than 3000 eligible faculty excel in all research areas on this campus. Why me? Because of my students, postdoctoral scholars, visiting scholars, collaborators, and colleagues. They deserve most of the credit for this honor. I accept it on their behalf. It is a team effort, like in a honey bee colony.”
"Walter is truly a renaissance man," wrote Hammock. "He chaired our entomology department from 2006 to 2008, and under his tenure, our department was ranked No. 1 in the country. I've long admired (1) his rigorous fundamental research programs supported by National Science Foundation, National Institutes of Health, and the U.S. Department of Food and Agriculture, and other agencies, (2) how he tackles and solves multiple challenging problems in insect olfaction and chemical ecology, (3) his grasp of how to organize and moderate highly successful worldwide research webinars (4) his generosity in helping other succeed and (4) his finely honed sense of humor."
“Walter has been exceptionally conscientious, active, and generous in professional service at UC Davis,” Hammock pointed out. “In August of 2021, he achieved a ‘first' for international science communication when he organized and led the extraordinary virtual conference ‘Insect Olfaction and Taste in 24 Hours Around the Globe.' I especially applaud him for elucidating the mode of action of the insect repellent DEET, developed in 1946 and known as ‘the gold standard of
repellents.' Its mode of action remained an enigma for six decades until Walter's discovery. Inresearching the neurons in mosquito antennae sensitive to DEET, he isolated the first DEET-sensitive odorant receptor, paving the way for the development of better repellents.”
Leal is a newly elected trustee of the Royal Entomological Society, the 13-member council that governs the 190-year-old international organization. He is the first UC Davis scientist to be elected a trustee. And he's chair of the Council of the International Congresses of Entomology, the body that ensures the continuity of the international congresses of entomology. He co-chaired the 2016 International Congress of Entomology, which drew 6,682 registrants from 102 countries to Orlando, Fla.
Among Leal's many honors: Fellow of the Entomological Society of America (2009), American Association for the Advancement of Science (2005), and the National Academy of Inventors (2019).
A native of Brazil, Leal joined the UC Davis entomology faculty in 2000, after serving as the head of the Laboratory of Chemical Prospecting, National Institute of Sericultural and Entomological Science (NISES), Ministry of Agriculture, Forestry, and Fisheries, Japan. In 2013, he accepted a position as professor of biochemistry, Department of Molecular and Cellular Biology. (See news story)
Frankly, we don't know how Leal does it all. He not only excels at research, teaching and public service, but he is widely known as "The UC Davis Ambassador," organizing campus-wide celebrations for faculty transitioning to emeriti.
As an aside, two UC Davis entomology faculty members scored two, but not three, of the Academic Senate's coveted awards. Bruce Hammock received the Distinguished Faculty Research Award in 2001, and the Distinguished Teaching Award (graduate student/professional category) in 2008. UC distinguished professor of entomology, James R. Carey, took home the Academic Senate's Distinguished Teaching Award (undergraduate student category) in 2014 and the Distinguished Scholarly Public Service Award in 2015.
Six other entomology faculty members have received Academic Senate awards:
- UC Davis distinguished professor Jay Rosenheim, Distinguished Teaching Award (undergraduate student category) in 2011
- UC Davis distinguished professor Lynn Kimsey (now emerita), Distinguished Scholarly Public Service Award in 2016
- UC Davis distinguished professor Frank Zalom, Distinguished Scholarly Public Service in 2017
- UC Davis professor and now department chair Joanna Chiu, Distinguished Teaching Award (graduate/professional category) in 2022
- UC Davis distinguished professor Diane Ullman, Distinguished Teaching Award (undergraduate category) in 2022
And the latest to join the winner's circle: Professor Louie Yang won the Distinguished Teaching Award (undergraduate category), announced today. More on this amazing teacher and mentor is pending.
- Author: Kathy Keatley Garvey
EicOsis Human Health LLC, the Davis-based pharmaceutical company developing a non-narcotic drug to relieve chronic pain and inflammation, today announced the next step in its ongoing human clinical trials: the initiation of Phase 1b to test the safety of its drug candidate, EC5026.
The ongoing double-blind, placebo-controlled Phase 1b study is designed to investigate the safety and pharmacokinetics of daily doses of EC5026 over seven days.
EC5026, an inhibitor of the soluble hydrolase enzyme (sEH), was discovered and patented at EicOsis based on previous patents and research papers from the laboratory of UC Davis distinguished professor Bruce Hammock during his half-century of research.
“EC5026 plays a crucial role in regulating the metabolism of signaling lipids and responding to inflammation and other stress responses caused by trauma or disease,” said Hammock, who holds a joint appointment with the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. “We found sEH to be a target for treating pain, inflammation, cancer and other diseases.”
By inhibiting sEH, EC5026 alleviates pain by preventing the breakdown of natural analgesic and anti-inflammatory fatty acids. Preclinical studies demonstrate no sedation or other adverse behavioral effects and no signs of addiction.
“Many regulatory molecules are controlled as much by degradation as biosynthesis,” Hammock explained. "The epoxy fatty acids rapidly degraded by the sEH control blood pressure, fibrosis,immunity, tissue growth, depression, pain, and inflammation, to name a few processes.”
“The initial results from Cohort 1 appear to replicate the very favorable safety profile we observed in our previous two Phase 1a clinical studies where there were no adverse behavioral, cardiovascular, or neurological effects over five ascending single-dose levels,” said Dr. William Schmidt, EicOsis vice president of clinical development. “The maximum dose level was 5 to 10-fold higher than the anticipated analgesic dose in humans.”
“If Cohort 2 dosing also proceeds without clinically significant adverse effects and a favorable pharmacokinetic profile for once-a-day dosing,” Schmidt continued, “this provides encouragement for initiating our first analgesic efficacy study in the second quarter of 2024.”
EicOsis plans to initiate its first pain patient study in April 2024 “to evaluate safety and analgesic effects in patients with a spinal cord injury who have failed to achieve satisfactory pain relief with existing non-opioid chronic pain medications,” said Cindy McReynolds, EicOsis chief executive officer and former director of research.
“Initiation of the Phase 1b program represents a significant milestone for EicOsis Human Health and demonstrates the success and dedication of our team to make this happen,” said McReynolds, who holds a doctorate in pharmacology and toxicology from UC Davis. “Demonstrating safety in Phase 1b studies will allow us to evaluate efficacy in patients and bring forward safe and effective treatments for several serious diseases. For example, the sEH inhibitors are being considered for use for treatment of cancer in the UC Davis Comprehensive Cancer Center, and neurological disease through the UC Davis Health's designated Parkinson's Foundation Center of Excellence.”
“As a potential anti-inflammatory fatty acid, EC5026 holds promise in addressing neuroinflammation, a key factor in the manifestation and even progression of Parkinson's,” said Zhang, who holds both an M.D. and a PhD. “Ensuring its safety profile in healthy individuals is fundamental for establishing a foundation for further clinical trials. this investigation provides valuable insights into design and overall safety parameters, paving the way for the next stages in advancing this innovative therapeutic approach for Parkinson's disease."
The FDA granted Fast Track status to EC5026 in April 2020 to support the unmet medical need for safe and effective non-opioid analgesics. EicOsis clinical scientist Irene Cortés Puch, who authored the successful application, commented: “Both our commitment and focus at EicOsis Human Health are guided by a genuine concern for the well-being of patients and recognizing the importance of identifying effective pain management alternatives. Therefore, the initiation of this Phase 1b clinical trial is an exciting step in advancing our mission to provide safer and effective treatments.”
Hammock traces his research on chronic pain to his earlier work on how a caterpillar becomes a butterfly; a key enzyme, epoxide hydrolase, degrades a caterpillar's juvenile hormone, resulting in metamorphosis.
A member of the UC Davis faculty since 1980, Hammock founded ;EicOsis in 2011 and served as its chief executive officer until February 2023 when he transitioned to scientific officer and chairman of the board of directors. Highly honored by his peers, he is a member of the National Academy of Inventors and the National Academy of Sciences and received the 2020 Lifetime Achievement Award in Innovation from UC Davis Chancellor Gary May. Hammock has authored or co-authored more than 1400 peer-reviewed publications and holds more than 95 patents in agriculture, environmental science and medicinal chemistry.
EicOsis (pronounced eye-co-sis), derives its name from eicosanoids, “the major backbone of chemical mediators in the arachidonate cascade,” McReynolds said. “It symbolizes the epoxide group in chemistry, which is key to the anti-inflammatory chemical mediators and where the biochemical target called soluble epoxide hydrolase works.”
Approximately 50 million Americans (20 percent of the population) suffer from chronic pain, according to the Centers for Disease Control and Prevention. The annual economic toll is $560 billion, encompassing direct medical expenses, lost productivity, and disability claims.
More information on the Phase 1b multiple-ascending dose clinical study is available at https://clinicaltrials.gov/study/NCT06089837.
- Author: Kathy Keatley Garvey
Hammock, internationally recognized for discovering a new group of human chemical mediators, is a newly inducted Fellow of the California Academy of Sciences (CAS). (He's also our favorite to some day win the Nobel Prize, as we've told him many times!)
Hammock, who holds a joint appointment with the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center, was inducted along with 13 other Fellows on Nov. 14 during the annual Fellowship meeting. He joins the ranks of more than 500 Academy Fellows, a governing group of distinguished scientists and other leaders who have made notable contributions to scientific research, education, and communication.
“We're proud to announce 2023's distinguished pool of new Fellows—each of their contributions to science and society represent major advancements in their respective fields,” said Academy Dean of Science and Research Collections Shannon Bennett. “Our Fellows body is a group of future thinkers and innovators whose leadership inspires the next generation of scientists, science educators, story-tellers and change-makers. We look forward to forging a future with our new Fellows that advances the Academy's mission to regenerate the natural world through science, learning, and collaborative partnerships.”
A member of the UC Davis faculty since 1980, Hammock was nominated by colleagues James R. Carey, UC Davis distinguished professor, and Robert E. Page Jr., UC Davis distinguished emeritus professor and emeritus provost of Arizona State University. The CAS Board of Trustees selects the Fellows.
Hammock discovered that regulating degradation of insect hormone mediators is as important as biosynthesis in development. He applied this toward the development of green chemical and the first recombinant viral pesticide. He asked if the same systems of metabolism of chemical mediators could be important in other species, notably man, resulting in the discovery of a new group of human chemical mediators. By inhibiting a key enzyme in this pathway, beneficial natural mediators increased there by showing benefit in treating multiple diseases including arthritis, cancer, Alzheimer's with the resulting drug candidates currently in human trials to treat pain.
Hammock founded the Davis-based pharmaceutical company, EicOsis LLC, formed in 2011 to develop an orally active non-addictive drug for inflammatory and neuropathic pain. The former chief executive officer, he now serves on the board of directors.
Hammock directed the UC Davis Superfund Research Program (funded by the National Institutes of Health's National Institute of Environmental Health Sciences) for nearly four decades, supporting scores of pre- and postdoctoral scholars in interdisciplinary research in five different colleges and graduate groups on campus.
He is a fellow of the National Academy of Inventors and the National Academy of Sciences., and the Entomological Society of America. He is the recipient of scores of awards, including the first McGiff Memorial Awardee in Lipid Biochemistry; and the Bernard B. Brodie Award in Drug Metabolism, sponsored by the America Society for Pharmacology and Experimental Therapeutics. At UC Davis he received the Distinguished Teaching Award and the Faculty Research Lectureship. In 2020, he received a Lifetime Achievement Award from UC Davis Chancellor Gary May.
Hammock is known for his expertise in chemistry, toxicology, biochemistry and entomology. Early in his career, he founded the field of environmental immunoassay, using antibodies and biosensors to monitor food and environmental safety, and human exposure to pesticides. His groundbreaking research in insect physiology, toxicology led to his development of the first recombinant virus for insect control.
A native of Little Rock, Ark., Hammock received his bachelor's degree in entomology (with minors in zoology and chemistry) magna cum laude from Louisiana State University, Baton Rouge, in 1969. He received his doctorate in entomology-toxicology from UC Berkeley in 1973. Hammock served as a public health medical officer with the U.S. Army Academy of Health Science, San Antonio, and as a postdoctoral fellow at the Rockefeller Foundation, Department of Biology, Northwestern University, Evanston, Ill.
In the Army, he served as a medical officer at Fort Sam, Houston, and what he saw--severely burned people in terrible pain--made a lasting impression on him and steered him toward helping humankind.
Fun Fact: For years Hammock--who believes science should be fun and camaraderie is crucial-- hosted water balloon battles on the Briggs Hall lawn. It was not "Fifteen Minutes of Fame"; it was "Fifteen Minutes of Aim." See Bug Squad blog.
Check out UC Davis distinguished professor Walter Leal's video of the Fellows' induction. (A screen shot is below) Leal is on X (used to be Twitter) at @wsleal2014.
- Author: Kathy Keatley Garvey
The research involves the development of a DNA-based sensor amplification system demonstrated in a fluorescence immunoassay that can detect, both simply and rapidly, trace amounts of organophosphate pesticides (OPs) in food products.
The paper, “Competitive Fluorescent Immunosensor Based on Catalytic Hairpin Self-Assembly for Multiresidue Detection of Organophosphate Pesticides in Agricultural Products,” appeared in the February edition of the Food Chemistry journal and is republished in June as “Paper of the Month."
Maojun Jin, who served a year (September 2019 to September 2020) as a visiting scholar in the Hammock laboratory, UC Davis Department of Entomology and Nematology, led the research team, and is the senior author and corresponding author. He is now a professor in the Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences. His doctoral student, Yuanshang Wang, is the first author.
“I'm very proud of what Maoiun and his team have accomplished,” said Hammock, who directs the NIEHS-UC Davis Superfund Research Program. The research was partially funded by his Superfund grant, and his NIEHS RIVER (Revolutionizing Innovative, Visionary Environmental Health Research) Award.
In addition, the research drew financial support from the National Natural Science Foundation of China, Central Public-interest Scientific Institution Basal Research Fund, and the Central Public Interest Scientific Institution Basal Research Fund for the Chinese Academy of Agricultural Sciences.
(See full story on the UC Davis Department of Entomology and Nematology website. No images can currently be loaded on the Bug Squad blog due to server issues.)