Bradley White, assistant professor at UC Riverside, will speak on “Ecological Genomics of Malaria Mosquitoes” at the UC Davis Department of Entomology seminar from 12:05 to 1 p.m. in Room 1022 of the Life Sciences Building, corner of Hutchison and Kleiber Hall drives.
Professor Gregory Lanzaro of the UC Davis School of Veterinary Medicine will introduce White. Plans call for video-recording the seminar for later posting on UCTV.
"Anopheles gambiae is the most important malaria vector in the world,” White says in is abstract. “Remarkable adaptive flexibility has enabled this mosquito to track humans across the diverse ecoclimates of sub-Saharan Africa where it thrives in both highly mesic and xeric conditions. These rapid, recent ecological adaptations have driven incipient speciation into two ecotypes, which differentially exploit permanent and temporary larval habitats. Within each nascent species, abundant chromosomal inversion polymorphisms facilitate adaptation to local conditions along latitudinal environmental gradients."
“To elucidate the genetic basis of ecological adaptation in Anopheles gambiae, we performed a series of genome-wide divergence scans, which revealed candidate regions subject to recent natural selection. Dissection of one of these genomic regions established a link between naturally occurring allelic variation and an adaptive phenotype. In the context of evolutionary genomics, these studies shed light on the maintenance of inversion polymorphisms and also provide insight into the genomic architecture of reproductive isolation. From a public health standpoint, this work demonstrates how divergent ecological selection can impact the vectorial capacity of Anopheles gambiae -- with consequences for malaria epidemiology and control.”
White began working on mosquitoes as an undergraduate at Oberlin College in Ohio. “At the time, West Nile virus (WNV) was sweeping through the midwest and during the summers I participated in a project to identify the Culex vectors of WNV and to determine environmental factors affecting their abundance,” he said. “After leaving Oberlin, I spent the next seven years in Nora Besansky's lab at Notre Dame where I focused on the population genomics of the African malaria mosquito Anopheles gambiae."
White, who joined the UC Riverside Department of Entomology faculty in 2011, focuses his research on quantitative and functional genomics of Anopheline malaria vectors.
More information? Check out his website at http://www.mosquitogenomics.org.
This year's event, set Wednesday, April 25 from 9 a.m. to 4 p.m. in Room 1031 of the Gladys Valley Hall, School of Veterinary Medicine, will include presentations on the historical, current and future efforts of malaria control, as well as updates on other vector biology research.
The UC Davis World Malaria Day is an opportunity "for students and researchers engaged in vector biology and genetics research to come together to discuss their research efforts,” said spokesperson Michelle Sanford, a postdoctoral scholar in the UC Davis Vector Genetics Lab.
The event supports World Malaria Day and the Roll Back Malaria Program in promoting education and research in the fight against malaria.
How did the UC Davis World Malaria Day observance originate? It was launched in 2007 by the (now folded) UC Mosquito Research Program, a UC Agricultue and Natural Resources program based in the UC Davis Department of Entomology and directed by medical entomologist Gregory Lanzaro. Lanzaro is now a professor in the Department of Pathology, Microbiology and Immunology of the School of Veterinary Medicine.
For the last several years, the Vector Genetics Lab has funded the World Malaria Day observance through a National Institutes of Health training grant.
Lanzaro and his "blood brother" medical entomologist Anthony Cornel direct the Vector Genetics Lab research programs. They've been doing research in Africa together for years. Cornel is an associate professor in the UC Davis Department of Entomology and a mosquito researcher at the Kearney Agricultural Research and Extension Center, Parlier.
The target: malaria, a mosquito-borne disease caused by infected Anopheles mosquitoes transmitting Plasmodium parasites.
The bad news is that more than half of the world's population is at risk for malaria. According to the World Malaria Report 2011, more than 216 million cases of malaria and an estimated 655 000 deaths occurred worldwide in 2010. Children in Africa are the still most susceptible to malaria; a child dies every minute of the disease.
The good news: Due to investments in malaria control, malaria mortality rates have dropped by more than 25 percent globally since 2000. Statistics show that malaria deaths in Africa have been cut by one-third within the last decade, according to the World Health Organization (WHO).
The strides we're making in tackling this massive killer are reflected in this year's World Malaria Day theme: "Sustain Gains, Save Lives: Invest in Malaria."
Sustain. Save. Invest. Well said.
Postdoctoral researcher Rebecca “Becky” Trout-Fryxell (right), who studies Culex and Anopheles mosquitoes with University of California, Davis medical entomologists Anthony Cornel and Gregory Lanzaro, just received an award designating her as one of the top young entomologists in the nation.
Trout-Fryxell won one of the five John Henry Comstock Graduate Student Awards presented at the Entomological Society of America’s 58th annual meeting, held recently in San Diego. The Southwestern Branch of ESA selected her at its most outstanding entomology graduate student in a region encompassing Alabama, Arkansas, Florida, Georgia, Louisiana, Mississippi, North Carolina, South Carolina and Tennessee, plus the U.S. territories of Puerto Rico and the U.S. Virgin Islands.
The other four ESA branches—Pacific, Eastern, North Central, and Southwestern Branch—also each selected a recipient.
Trout-Fryxell works with population genetics of the West Nile virus vector Culex pipiens, and does research on the malaria mosquito, Anopheles gambiae.
Fryxell joined the UC Davis team in April of 2009. Cornel is an associate professor of entomology, with offices and labs at UC Kearney Agricultural Center, Parlier, and UC Davis. Lanzaro is a professor in the Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine.
Trout-Fryxell previously won a Isley-Duport Entomology Scholarship and was a member of the 2007 Linnaean Games National Championship team from the University of Arkansas. The Linnaean Games is a college bowl-type competition featuring questions about insects, entomologists and entomological facts.
Trout-Fryxell has published her research in Journal of Medical Entomology, Journal of American Mosquito Control, Emerging Infectious Diseases, Medical and Veterinary Entomology, among others, on topics ranging from mosquitoes and ticks to bed bugs.
Trout-Fryxell received her master’s degree in entomology from the University of Kentucky, Lexington, where she studied with major professor Grayson Brown. Her research focused on reducing mosquito populations in the peridomestic environment.
She received her doctorate in entomology from the University of Arkansas, Fayetteville, last May. Studying with major professors Dayton Steelman and Allen Szalanski, she completed her dissertation on the distribution and occurrence of ticks in Arkansas, also examining tick-host pathogen interactions.
The four other winners of the coveted John Henry Comstock Awards:
Pacific Branch: Ashfaq Sial, Washington State University
North Central Branch: Anna Fiedler, Michigan State University
Southwestern Branch: Joe Lewis, University of North Texas
Eastern Branch: Gaylord Desurmont, Cornell
Back, in 2008, mosquito researcher Christopher Barker of the William Reisen lab at UC Davis won the Comstock award from the Pacific Branch.
Davis is definitely a good place to be for mosquito research!
It was a major milestone, sequencing the genome of Culex quinquefasciatus, the so-called “southern house mosquito.”
The research, spearheaded by UC Riverside geneticists and published in the Oct. 1, 2010 edition of Science, involved scientists from 37 other institutions. The mosquito is a medically important mosquito that transmits the West Nile virus, St. Louis encephalitis, lymphatic filariasis and other diseases.
UC Riverside research entomologist Peter Arensburger led the bioinformatics component of the multiyear research effort, launched in 2004.
Cornel collected and established the mosquito colony that was sequenced. Cornel is an associate professor of entomology at UC Davis who directs the mosquito research lab at UC Kearney Agricultural Center, Parlier.
“We have multiple sub colonies of the Johannesburg colony now established in numerous insectaries worldwide,” said Cornel.
Lanzaro, a longtime collaborator with Cornel, is a professor in the School of Veterinary Medicine and former director of the UC Mosquito Research Program and the Center for Vectorborne Diseases. Both Cornel and Lanzaro serve as graduate student advisors in the UC Davis Department of Entomology. They mentor future medical entomologists.
The Hammock lab played a role in annotating and examining divergence of esterases and glutathione-S tranferases in this mosquito. Bruce Hammock is a distinguished professor of entomology. The lab of Walter Leal, professor of entomology, added expertise in chemical ecology.
Cornel hailed the research as “another milestone in mosquito genomics—we now have a full genome sequence of a third medically important mosquito, Culex quinquefasciatus.”
Said Cornel: "This is the first species within the Culex genus fully sequenced and now offers many opportunities for research on comparative genomics and post genomics between three mosquito species now fully sequenced—namely the major malaria vector, Anopheles gambiae; the major dengue virus vector, Aedes aegypti; and a major vector of West Nile virus, Culex quinquefasciatus.”
The genome of Culex quinquefasciatus, Cornel said, is much larger than the other two species--52 percent more than Anopheles gambiae and 22 percent more than Aedes aegypti. “Research on these three mosquitoes--how they find their hosts and vector diseases and the mechanisms involved--will likely blossom in the near future.”
This is indeed research to watch.