The banner fronting Briggs Hall, home of the UC Davis Department of Entomology and Nematology. (Photo by Kathy Keatley Garvey)

The UC Davis Department of Entomology and Nematology and the Bohart Museum of Entomology will be participating in the virtual 107th annual UC Davis Picnic Day on Saturday, April 17, a traditional event being held untraditionally this year due to the COVID-19 pandemic. 

The entomological events will include cockroach racing and a series of talks. Among them: Bohart Museum associate and natural historian Greg Kareofelas will present a pre-recorded video on Gulf Fritillary butterflies and entomologist Jeff Smith,  the  Bohart's volunteer curator of the Lepidoptera collection, will deliver a live Zoom talk on  butterfly and moth mimicry from 1 to 2 p.m. 

Said Smith: "For my presentation on mimicry within Lepidoptera, it will briefly mention camouflage and spend most of the time on mimicry for defense-- mimics of toxic or distasteful species, mimicry using odors or sounds, mimics of snakes or spiders, and mimics of non-food materials such as bird feces."

More events--and the schedule--are pending.

The Bohart Museum, temporarily closed, is located in Room 1124 of the Academic Surge Building on Crocker Lane. Directed by Professor Lynn Kimsey, the Bohart Museum includes nearly eight million insect specimens, a live "petting zoo" (Madagascar hissing cockroaches, stick insects and tarantulas) and an online gift shop stocked with insect-themed t-shirts, jewelry, hoodies, books, posters and more.

Bohart Museum associate Greg Kareofelas answers questions from open house visitors, prior to the COVID-19 pandemic. The Bohart Museum is currently closed due to the pandemic. (Photo by Kathy Keatley Garvey)

Discovering Silver Linings
This year's theme is “Discovering Silver Linings.” Despite all that has happened this year, the UC Davis community has continued to find silver linings everywhere, the Picnic Day officials reported on their website. "Our campus always strives to inspire hope and works towards a better and brighter tomorrow."

Last year's in-person events also were canceled and some virtual events took place.

Entomologist Jeff Smith, curator of the Lepidoptera collection at the Bohart, will deliver a Zoom presentation on April 17, UC Davis Picnic Day. (Photo by Kathy Keatley Garvey)

"This long-standing campus tradition began in 1909 when the University Farm invited the surrounding community to view their new dairy barn. Two thousand visitors attended, bringing picnics to complement the coffee, cream, and sugar provided by the University. Following the success of the 1909 picnic, the faculty of the University Farm continued to plan and sponsor the event until a student committee took over the task in 1912. Through the years of Picnic Day history, the event has only been canceled five times. In 1924, an outbreak of hoof-and-mouth disease among the cowherds caused the first cancellation. In 1938, delayed construction of the gymnasium, which was needed to accommodate the ever-increasing number of participants, led to a second cancellation. During World War II, the Army Signal Corps controlled the campus, and Picnic Day disappeared from 1943 to 1945. Since 1946, Picnic Day has been growing strong and now boasts an annual attendance of more than 70,000 people. This year, there will be more than 200 events on campus and an estimated 75,000 visitors attending this special event. Since 1959, the parade was extended to include downtown Davis to celebrate the fact that Davis became a separate UC campus and not just the Farm School for UC Berkeley."

Cindy McReynolds, lead author

A blood plasma biomarker discovered in hospitalized COVID-19 patients may not only predict the severity of adult respiratory distress syndrome (ARDS) but further research may lead to inhibiting the progression, a team of eight University of California researchers announced today.

The UC researchers, primarily from the laboratory of UC Davis distinguished professor Bruce Hammock,  found that four compounds in the blood of COVID-19 patients are highly associated with the disease. Their paper, “Plasma Linoleate Diols Are Potential Biomarkers for Severe COVID-19 Infections,” is published as open access in the current edition of Frontiers in Physiology.  

ARDS, characterized by fluid build-up in the lungs, is the second leading cause of death in COVID-19 patients, next to viral pneumonia, according to the National Center for Biotechnology Information.

“Different outcomes from COVID-19 infections are both terrifying from a human health perspective and fascinating from a research perspective,” said UC Davis lead author and doctoral candidate Cindy McReynolds of the Hammock lab. “Our data provide an important clue to help determine what impacts the severity of COVID-19 outcomes. Initially, we focused on the immune response and cytokine profile as important drivers in severity, but considering what we now know from our study and others in the field, lipid mediators may be the missing link to answering questions such as why some people are asymptomatic while others die, or why some disease resolves quickly while others suffer from long-haul COVID.” 

The compounds, known as leukotoxins and leukotoxin diols, originate from linoleic acid, the body's most abundant dietary fat, said Hammock, who holds a joint appointment in the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center and directs the National Institute of Environmental Health Sciences (NEIHS) Superfund Research Program at UC Davis. “The leukotoxins (also called EpOMEs) are converted to the leukotoxin diols (also called DiHOMES) by the soluble epoxide hydrolase we work on.”

Jun Yang, corresponding author

“So the leukotoxins and leukotoxin diols,” Hammock said, “are indicators of respiratory problems in COVID-19 patients as plasma biomarkers. They also present a pathway for reducing ARDS in COVID-19 if we could inhibit the soluble epoxide hydrolase, a key regulatory enzyme involved in the metabolism of immune resolving fatty acids.”

Professor John Imig, director and eminent scholar of the Medical College of Wisconsin's Drug Discovery Center, who was not involved in the study, said: “The COVID-19 pandemic has demonstrated that coronaviruses can have deadly consequences. Lung distress is a major reason for death in COVID-19 patients infected with the coronavirus (SARS-CoV-2). The findings of McReynolds et al. identified lipids called leukotoxin diols in the blood of COVID-19 patients that could act as a biomarker for lung distress. In addition, leukotoxin diols could be responsible for lung distress in COVID-19 patients. Excitingly, this suggest that therapies to lower leukotoxin diols could treat lung distress and prevent death in COVID-19 patients.”  

“The findings presented in this paper bring important attention to a role for oxylipin metabolites in COVID-19 infections,” said Professor A. Daniel Jones of Michigan State University's Department of Biochemistry and Molecular Biology and director of the university's Research Technology Facility's Mass Spectrometry and Metabolomics Core. “Most notably, metabolites known as DiHOMEs which have been previously implicated in lung inflammation show promise for their potential to predict outcomes in COVID patients and guide therapeutic, and perhaps dietary interventions beneficial to human populations.” Jones, who was not involved in the study, serves as secretary of the Metabolomics Association of North America.  

The UC Davis scientists used clinical data collected from six patients with laboratory-confirmed SARS-CoV-2 infection and admitted to the UC Davis Medical Center, Sacramento, and 44 healthy samples carefully chosen from the healthy control arm of a recently completed clinical study.

Ameer Taha, UC Davis lipid metabolism researcher

The Hammock lab's 50-year research on soluble epoxide hydrolase (sEH) and its inhibitors led the professor to found and direct EicOsis Human Health, a Davis-based company that is developing a potent soluble epoxide hydrolase inhibitor for pain relief.  Epoxy fatty acids control blood pressure, fibrosis, immunity, tissue growth, depression, pain, inflammation and other processes.

But more recently, the Hammock lab has turned its attention to using sEH as a means to resolve inflammation associated with COVID-19 and the fibrosis that can follow.

Lipid metabolism researcher Ameer Taha of the UC Davis Department of Food Science and Technology pointed out that linoleic acid is an essential fatty acid present in only small amounts in our evolutionary diets. “In addition to nutritional and structural roles of linoleate, minor linoleate metabolites including the leukotoxin diols (also known as DiHOMEs) regulate a number functions including body temperature, cardiac health and vascular permeability.  This study cautions that now with dietary linoleate levels at an all-time high, in periods of high stress as with COVID-19, these regulatory functions may become detrimental.” 

The paper is the work of Hammock, McReynolds and Jun Yang of the Department of Entomology and Nematology and EicOsis Human Health; Irene Cortes-Puch of the Department of Entomology and Nematology, EicOsis Human Health, and the Department of Internal Medicine's Division of Pulmonary Critical Care and Sleep Medicine; Resmi Ravindran and Imran Khan of the Department of Pathology and Laboratory Medicine; Bruce G. Hammock of UC Davis Department of Veterinary Medicine, Aquatic Health; and Pei-an Betty Shih of the UC San Diego Department of Psychiatry. 

“This study resulted from an exciting collaboration with Imran Khan and Angela Haczku of the UC Davis School of Medicine to identify potential biomarkers for differentiating the severity of COVID-19 diseases,” said Yang, the corresponding author.

The research drew financial support from several National Institutes of Health agencies: National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program and R35 grant,  National Institute of General Medical Sciences (NIGMS),and the National Institute of Mental Health (NIMH).

Resources:

• EicOsis: Developing a New Approach to Treat Pain
• Bruce Hammock:  Lifetime Achievement Award from the Chancellor 
• Cindy McReynolds Receives Major NIH Training Grant
• Cancer Team's Research Paper Named Journal of Clinical Investigation's Editor's Pick (Includes Bruce Hammock and Jun Yang)

Contacts:

• Bruce Hammock at bdhammock@ucdavis.edu 
• Cindy McReynolds at cbmcreynolds@eicosis.com or cbmcreynolds@ucdavis.edu
• Jun Yang at junyang@ucdavis.edu

Feb. 28 is the last day to donate to the current crowdfunding efforts of the UC Davis Biodiversity Museum Day/Month, Honey Bee Haven and the California Master Beekeeper Program.

• Biodiversity Museum Day/Month: https://crowdfund.ucdavis.edu/project/24310
• Honey Bee Haven: http://crowdfund.ucdavis.edu/project/24323 
• Master Beekeepers: http://crowdfund.ucdavis.edu/project/24314 

UC Davis Biodiversity Museum Day sign

“Last year our in-person event occurred just before the global pandemic. Together 13 biological collections welcomed 4,000 people to campus. It involved nearly 300 students, staff and faculty committed to science communication and outreach. This February it had to take place virtually with live webinar talks and pre-recorded activities throughout the month, including some content in Spanish.” 

"Our goal right now is to get 100 individual donations by Saturday when the crowd fund ends," Yang said.  

Those participating in the 2021 Biodiversity Museum Day/Month:  

• Anthropology Museum
• Arboretum and Public Garden
• Bohart Museum of Entomology
• Botanical Conservatory
• California Raptor Center
• Center for Plant Diversity
• Häagen-Dazs Honey Bee Haven
• Nematode Collection
• Marine Invertebrate Collection 
• Museum of Wildlife and Fish Biology
• Paleontology Collection
• Phaff Yeast Culture Collection
• Viticulture and Enology Collection

Beekeeper holding a frame. (Photo by Kathy Keatley Garvey)

The program is raising funds for an online, accessible, 'Beekeeper's Apprentice' course that is educational, engaging and entertaining for all ages.

From the website: "Your donation is a legacy to help ensure the health and longevity of our honey bees. Money raised for our "Beekeepers' Apprentice" course is an investment in science-based knowledge relative to our food security and the health of our environment now and for future generations - let's educate as many people as we can about the plight of our precious honey bees. Together we can bee the change!"

As of Friday at 10:30 a.m., the donations amounted to $16,823 or 67 percent of the $25,000 goal.

A honey bee and a bumble bee sharing a purple coneflower. (Photo by Kathy Keatley Garvey)

From the website: "Our goal is $5000 to purchase plants, irrigation supplies, and tools for the Haven to continue our vital mission of inspiration and education about bees and the plants that support them." 

As of Friday at 10:30, the donations amounted to $2345 or 46 percent of the $5000 goal.

For more information, see their websites or the Feb. 1 news story on the Department of Entomology and Nematology website.

Jill Oberski, fourth-year doctoral student

Ziv Lieberman, first-year doctoral student

Zach Griebenow, fourth-year doctoral student

That's just some of the information to be showcased at the UC Davis Biodiversity Museum Month program on Saturday, Feb. 13 from 11 a.m. to noon when three doctoral students in the Phil Ward lab, UC Davis Department of Entomology and Nematology, take the helm.  Oberski, a fourth-year doctoral student, and Ziv Lieberman, a first-year doctoral student, will talk about the diversity of ants and field questions, followed by doctoral candidate Zach Griebenow's presentation on his research.

Then on Saturday, Feb. 20, from 11 a.m. to noon, Professor Phil Ward will host "All About Ants," billed as a "fun and lively question and answer session." The programs are free and family friendly. See http://biodiversitymuseumday.ucdavis.edu/live-programs.html for the Zoom links.

Zach Griebenow
Griebenow grew up in rural Kentucky and received his bachelor's degree in entomology in 2017 from The Ohio State University, undertaking undergraduate research with distinction on species boundaries in the Puerto Rican fauna of the subterranean termite Heterotermes (Griebenow et al. 2017).  

"As so everyone in the Ward lab, I study how different groups of ants are related to one another, and why they look and behave the way that they do," he said. "Specifically I study an obscure group called the Leptanillinae, which have no common name. As ants go, they are strange, and we know very little about them. So far, I have confidently teased out the major evolutionary relationships among leptanilline ants (Griebenow 2020; Griebenow, in press), but there is a lot more work to be done, particularly in comprehending the often bizarre structural modifications seen in the male Leptanillinae (legs that look like toothbrushes, etc.)."

Ziv Lieberman
Lieberman, born and raised in California, studied at the College of Marin before transferring to UC Davis to major in evolution, ecology and biodiversity, with a minor in insect evolution and ecology. "Prior to UC Davis, I spent several years working abroad for the California Academy of Science documenting historical ant specimens," Lieberman said. "At the end of my undergrad, I published my first paper, a revision of the poorly-understood (and very cute) African species of the ant genus Discothyrea."

In the Ward lab, Lieberman studies "ant evolution, specifically focusing on connecting evolutionary relationships (the ant 'family tree') with anatomy, using a combination of next-generation imaging techniques and large-scale genetic analyses. In particular, I am interested in describing and comparing internal anatomical features which are usually ignored, and understanding how these traits contribute to biodiversity."

Jill Oberski
Oberski grew up in Minnesota. "I was fascinated by insects from a very young age," she said. "I attended Macalester College, spent a few confused years on a pre-med track, and ultimately discovered a career in entomology was feasible and worth pursuing. This has led me to Phil Ward's ant systematics lab at UC Davis, where I'm now a PhD candidate."

"My research centers on the ant genus Dorymyrmex, which is commonly found all over the Americas," Oberski said. "Even though they're extremely common (Davis itself is home to two species!), we have no idea how many species there really are. In addition to discovering and naming these species, I'm really interested in biogeography and ancient history: Where did Dorymyrmex originate? How are the North American species related to the South American species? And how did they disperse before the isthmus of Panama was connected?"

Professor Phil Ward

Due to the COVID-19 pandemic, the 10th annual UC Davis Biodiversity Museum program is all virtual this year via webinars and pre-recorded presentations, and takes place throughout the month of February. The science-based event traditionally occurs on only one day--the Saturday of Presidents' Weekend, when families and friends gather on campus to learn first-hand about the UC Davis museums and collections. 

This year's biodiversity event is showcasing 12 museums or collections:

• Anthropology Museum
• Arboretum and Public Garden
• Bohart Museum of Entomology
• Botanical Conservatory
• California Raptor Center
• Center for Plant Diversity
• Häagen-Dazs Honey Bee Haven
• Nematode Collection
• Marine Invertebrate Collection 
• Museum of Wildlife and Fish Biology
• Paleontology Collection
• Phaff Yeast Culture Collection

For more information and the schedule, access these two formats on the UC Davis Biodiversity program website: (1) live talks and demonstrations and (2) pre-recorded talks and activities. Information on the biodiversity museum events also appear on social media, including Facebook, Instagram, and Twitter, @BioDivDay. 

To help support the Biodiversity Museum event, contributions are being accepted through a month-long crowdfunding campaign program at https://crowdfund.ucdavis.edu/project/24310.