A term paper written by UC Davis fourth-year student Jessica Macaluso for a longevity class taught by UC Davis distinguished professor of entomology James R. Carey, has won the top prize in the science, engineering and mathematics category of the Norma J. Lang Prize for Undergraduate Information Research.

Macaluso received $1000, and her research paper, “The Biological Basis for Alzheimer's Disease," will be published in eScholarship, an open-access scholarly publishing service affiliated with the University of California.  

This is the first time a student enrolled in a UC Davis Department of Entomology and Nematology class has won the universitywide competition, now in its fourth year.  The award memorializes Norma J. Lang (1931-2015), professor emerita of botany. 

Macaluso, who is majoring in psychology with a biological emphasis, and minoring in aging and adult development,  anticipates receiving her bachelor of science degree in the fall of 2020.

Carey, an internationally recognized teacher, instructs undergraduates in his classes--which usually exceed 200 students--how to research topics, use style sheets, and structure their papers. He has produced 13 videos on how to research and write a research paper, along with a new video on the use of style sheets. 

The Lang Prize recognizes undergraduate students whose research projects make extensive use of library resources, services and expertise. First, second and third-place prizes are awarded each year in two categories: science, engineering and mathematics; and arts, humanities and social sciences. Second place in the science, engineering and mathematics category went to Vincent Pan, a student doing research in the lab of ecologist Rick Karban, UC Davis Department of Entomology and Nematology, for several years. His paper: "Recent Advances in Elucidating the Function of Zebra Stripes: Parasite Avoidance and Thermoregulation Do Not Resolve the Mystery." (See recipients at https://bit.ly/3cPPsNt.)  

“Macaluso's term paper gives an in-depth synopsis of the biology of Alzheimer's disease, a prevalent form of dementia that impairs memory and cognition,” wrote the Norma J. Lang Prize judges. “Utilizing the library's databases and subject guides, Macaluso identified 20 sources from top scientific journals across multiple disciplines, including Nature and the Annual Reviews of Medicine, Neuroscience, Psychology and Public Health, to provide a comprehensive overview of the current state of the science on Alzheimer's.” 

In her abstract, Macaluso defined dementia as “a chronic ailment that results in severe alterations to the brain. Many forms of dementia exist such as Lewy body dementia, frontotemporal dementia, Wernicke-Korsakoff syndrome, and Alzheimer's disease. Alzheimer's disease is the most prevalent form of dementia and affects millions worldwide every year. Common symptoms of this disease include impaired thinking or an inability to make proper judgments.” 

“This currently incurable disease is caused by significant neuronal death in the brain due to of the accumulation of two neurodegenerative proteins: intercellular amyloid-beta plaques and intracellular tau tangles,” she wrote. “The interaction of these two proteins creates a feedback loop that facilitates the continual destruction of nerve cells in the brain. Because the destruction of nerve cells disrupts the neuronal connections in the brain, Alzheimer's disease results in significant memory deficits as well as impaired cognition. Moreover, with the use of human models and transgenic mouse models, researchers have been able to analyze the role of biology, genetics, and physiology in Alzheimer's disease. For example, mutations in the presenilin 1 (PSEN1) gene or the amyloid precursor protein (APP) gene predispose an individual to acquire early-onset Alzheimer's disease.” 

“Likewise, an individual can have an increased likelihood of developing late-onset Alzheimer's disease if they carry the ApoE4 variant of the apolipoprotein E (ApoE) gene. In summary, researchers are amply investigating Alzheimer's disease from a variety of biological faucets in an effort to treat or even cure this form of dementia.” 

 Macaluso went on to discuss three major risk factors affiliated with Alzheimer's disease: age, gender, and genetics.

 Macaluso penned “The Biological Basis for Alzheimer's Disease” as her term paper for Human Development-Aging 117 (Longevity) in the fall of 2019. “The purpose of this assignment was to utilize the library databases for research, improve both my writing and editing skills, and broaden my understanding of longevity with a topic of my choice," she wrote in her Norma J. Lang Prize application. "Moreover, this research paper served to expand my communication skills and bolster my intellectual confidence. A key requirement for this paper was to use at least ten sources, seven of which needed to be primary sources such as a research article or a review paper. Initially, I was quite daunted by the prospect of this assignment because I had only modest experience reading research papers or using the online library databases. I distinctly recall reading about this assignment on the syllabus and questioning if I was capable of such an onerous task. To my surprise, by the end of this quarter and after countless hours exploring the online library reserves, I completed my assignment and felt confident in my ability to utilize the UC Davis library resources.”

A 2019-2020 McNair Scholar, Macaluso has worked as an undergraduate research assistant for the Dynamic Memory Lab (Charan Ranganath Lab) since 2017. She serves on the Animal Care Staff at Young Hall; as a genetics tutor for the Academic Assistance and Tutoring Centers; and as  president of the America Red Cross Club at UC Davis. 

The UC Davis student, a native of Santa Barbara but raised in nearby Buellton, plans to enroll in graduate school in the fall of 2021 to study cognitive neuroscience or cognitive psychology.  Her career plans? "I'm thinking academia right now," she said. "I hope to finish my PhD, work as a postdoctoral fellow for a few years, and then pursue a professorship position."

Carey, a member of the UC Davis entomology faculty since 1980, is considered the preeminent global authority on arthropod demography. He directed the multidisciplinary, 11-institution, 20-scientist program, “Biodemographic Determinants of Lifespan,” which garnered more than $10 million in funding from the National Institute on Aging from 2003 to 2013. 

Highly honored by his peers for his teaching expertise, Carey received the Entomological Society of America's 2015 Distinguished Teaching Award; a 2018 Robert Foster Cherry Award from Baylor University, which presents international teaching awards; and the UC Davis Academic Senate's 2014 Distinguished Teaching Award, an honor given to internationally recognized professors who excel at teaching. 

(Undergraduate students can apply for the annual Norma J. Lang Prize here.)

“Food for thought” shouldn't just be a thought; it should be an integral part of any school curriculum,” says UC Davis agricultural entomologist Christian Nansen, an associate professor in the Department of Entomology and Nematology. 

 In a newly published article on “The School of Food” in Futurum, Nansen advocates that all school curricula be “rooted in a single dominator: food.” 

Biology, ecology and environmental science should be “taught based on subjects related to the growth of plants and animals,” Nansen writes. Literature, history, sociology and humanities should focus on “the importance of food concepts, like ‘breaking bread,' feasts and banquets.” 

“What I am proposing here is already being done, in part, as individual initiatives and projects,” he writes. “For example, many schools have a butterfly garden, biology labs keep colonies of insects, students grow some vegetables and have a few livestock animals. In some schools, students learn how to eat and cook healthy food.”

Futurum is a website geared toward students and teachers to become inspired and interested in science. It focuses on research, analysis and insights. 

Nansen, whose research interests include insect ecology, integrated pest management,  and remote sensing,  says that  such a focus on food “would strengthen, not weaken, the academic rigor that could be delivered to students of all age groups.” 

“That is, ‘food' as an educational denominator can be taught and approached with multiple goals in mind, and these would be similar to the current distinctions between practical and more theoretical classes. By engaging with students through the prism of food, we can make math, physics, history, biology, literature--all these topics more relevant to students and make the teaching more interactive and challenge-based.” 

Nansen acknowledges that it is crucial that schools teach students about traditional subjects and provide them with essential skill sets regarding problem solving, critical thinking and basic knowledge, but that that students “can all be taught very effectively through an underlying emphasis on food.” 

For example, he mentions that students of all ages can grow crop plants in small pots inside a classroom or outside (small plots and roof gardens), “and study growth as a function of time and growing conditions.” More advanced practical tasks could include developing irrigation systems, and plant and animal breeding programs.

Another example:  for engineering, computer sciences and food production, students could delve into solar panels, rainwater catchment systems and water recycling methods. At the more advanced level, they could integrate robotics and machine learning system. 

Nansen, linking chemistry with cooking, comments: “Cooking is nothing more and nothing less than applied chemistry. How does the pickling of vegetables work? What is happening when cream is whipped? What happens to food during heating and/or frying? Salting olives, fish and other types of meat has been practiced for thousands of years—how does this means of preserving food actually work?” 

In his article, Nansen also explains how food can be incorporated in such subjects as humanities, human history, social studies and math. 

Eating has changed over time, the professor acknowledges, “and it varies among countries and cultures, meaning that not all students view food in the same way.” But teachers can capitalize on diversity in the classroom, he relates. They can also address “societal challenges, such as obesity” and elevate levels of empowerment related to stresses, such as fear. 

In the article, Nansen shared a project he assigned to his 11-year daughter, Molly, during the sheltering-in requirements: “How much cabbage would be needed to meet the Vitamin K requirements for her entire class for a whole year?”

In addition to learning about the metric system, using Excel spread sheets, regression analyses and calculus, Molly investigated websites and came to several conclusions:

• A person can harvest about 3 kg per m2 (kilograms per square meter)
• A student her age has to have 105 grams of cabbage to meet daily vitamin K requirements

In addition, she created a cabbage-muffin recipe and calculated she would need to eat four muffins per day to meet the daily Vitamin K requirements. She also calculated she would need 2,291 m2 to grow enough cabbage to meet the daily vitamin K requirement for her entire school. It is age-dependent, so that was a bit tricky to figure out. 

And lastly, using Google Earth, Molly suggested where to place the cabbage field next to her school. (Her entire project is online as a sidebar.)

Virtual Youth Summit on Food and Education 2021 

Nansen said he seeks contact with teachers and headmasters "interested in pursuing this approach at some level at their school." 

"The idea is now to take this several steps further, through collaboration with teachers and their students, and set up a web-based platform to host an annual virtual youth summit on food and education!" he said. "That is, groups of students, in collaboration with their teachers and as part of course curricula, produce a 3-5 minute video describing a particular project they have executed. These videos would then be shown at the virtual youth summit, and we will organize review panels of students, teachers, and scientists to comment on the videos. These video projects would be divided into age groups and topics – still to be determined."

"I am hoping that we will be able to create a very special category of video projects describing two schools (have to be on separate continents) doing a project together," Nansen said. "As a start, we are pursuing the potential of a school in California working with a school in Uganda… which would be awesome!" 

"We may be able to obtain corporate sponsorships and therefore be able to offer prizes/awards to participating schools, teachers and student groups. With corporate sponsorships, we may also be able to offer logistical support to schools – computers, software licenses (to create videos), basic lab supplies and equipment to conduct experiments.'" 

"Just imagine a school being able to put on its website that a group of students competed in the Virtual Youth Summit on Food and Education 2021 and was selected as one of the winners! Students can put this experience on their resume when they later apply to university or jobs. Teachers can include this in their evaluation dossiers." 

"Initially, we need to identify teachers interested in joining this effort--ideally teachers from multiple countries," Nansen related. "Once we have 5-10 teachers committed, then we can start putting together the virtual platform and invite schools and teachers more broadly." School teachers and others potentially interested in getting involved can contact him at chrnansen@ucdavis.edu.

Thousands of viewers are expected to tune in for the second COVID-19 Symposium, organized and moderated by UC Davis distinguished professor Walter Leal, on Thursday, May 14 when a panel of experts in medicine and science will present up-to-date information and answer questions via Zoom and YouTubeLive.

The free public awareness event will take place from 1:30 to 4:30 p.m. Viewers can register and post advance questions on Zoom at https://bit.ly/2SUJ7t5. For YouTube Live, the link is https://bit.ly/3b8TAau.

UC Systemwide President Janet Napolitano, a former secretary of Homeland Security, will deliver the welcoming address. She will be introduced by UC Davis Chancellor Gary May, who delivered the welcoming address at the first COVID-19 Symposium.

Panelists are Dr. Allison Brashear, dean of the UC Davis School of Medicine; Dr. Atul Malhotra, professor of medicine, pulmonology, critical care, UC San Diego Health; Dr.  Emanuel Maverakis, professor of dermatology and immunology, UC Davis School of Medicine; and Dr. David Lubarsky, vice chancellor of Human Health Sciences and chief executive officer, UC Davis Health.

Among others participating will be Dr. Jane Sykes, professor of small animal internal medicine (infectious diseases emphasis) and chief veterinary medical officer, UC Davis School of Veterinary Medicine; and Dr. James M. Hotaling, associate professor, Department of Urology, School of Medicine, University of Utah; and several other guests.

Viewers are invited to ask advance questions as well as questions live. Former NASA astronaut Steve Robinson, now a UC Davis professor of mechanical and aerospace engineering, will be among those asking questions. Professor Robinson, who graduated from UC Davis in 1978 with dual degrees in mechanical and aeronautical engineering, saw Earth from outer space four times during NASA shuttle missions, including the 2005 Space Shuttle Discovery.

Questions will include:

• Can our pets place us at risk for contracting the coronavirus?
• Can we get the virus through sexual transmission?
• Can COVID-19 survivors get secondary infections?
• What research is underway on COVID-19 therapies, management and testing?

Professor Leal, a fellow of the National Academy of Inventors, a member of the Department of Molecular and Cellular Biology faculty and a former chair of the UC Davis Department of Entomology, Leal co-chaired the 2016 International Congress of Entomology. He is donating his organizational skills and his cutting-edge technology and video-conferencing expertise to host the symposium. The first symposium drew some 4000 views from 10 countries. 

“It is a pleasure to create these platforms to raise awareness and address COVID-19-related questions from the public,” Leal said.

The first symposium, with a welcoming address by UC Davis Chancellor Gary May, spotlighted the cutting-edge expertise of physicians, researchers, and a recovering COVID-19 patient. It is online at  https://bit.ly/2VurK3Z. It drew comment “I just wanted to thank you! You are my heroes.”  

“This give me a sense of hope and calmed my anxiety like nothing else,” letter writer Kim Allen continued. “To hear people, real doctors and scientists who are so knowledgeable talk about what is going on and why, is so appreciated. We need to know what we are contending with to fight it and be safe. You are all so much appreciated!”

DAVIS—A 16-member team of international researchers is targeting autism spectrum disorder (ASD) to see if a drug discovered in the Bruce Hammock lab at the University of California, Davis, can support efforts to control or block the neurodevelopmental disorder.

ASD, which impacts the nervous system, affects 1 percent of the U.S. population or 62.2 million globally. An estimated 64 percent and 91 percent of the population are at risk genetically.

The researchers' latest paper, “Maternal Glyphosate Exposure Causes Autism-Like Behaviors in Offspring through Increased Expression of Soluble Epoxide Hydrolase,” appears in the current edition of the Proceedings of the National Academy of Sciences (PNAS). Glyphosate is a broad-spectrum systemic herbicide and crop desiccant used to kill broadleaf weeds and grasses that compete with agricultural crops. 

“In the research of autism, brain-gut-microbiota axis plays a key role in ASD from human studies,” said lead researcher and neurobiologist Kenji Hashimoto of the Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. “Accumulating evidence suggests abnormal composition of gut microbiota in subjects with autism. In this study, we found abnormal composition of gut microbiota in offspring after maternal glyphosate exposure. Thus, exposure of glyphosate during pregnancy may cause abnormal composition of gut microbiota in offspring, resulting in the risk for autism.' 

The drug discovered in the Hammock lab inhibits sEH, a natural enzyme that regulates epoxy fatty acids, “which control blood pressure, fibrosis, immunity, tissue growth, depression, pain and inflammation to name a few processes,” said co-author Hammock, a distinguished professor with a joint appointment in the UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. Human clinical trials underway to see if the non-addictive drug relieves chronic pain. 

“It is critical to appreciate that mouse models are not absolutely predictive of the human situation,” Hammock said.“Similarly, maternal immune stress is simply a model that gives behavioral changes in the offspring.  That said, it is a relevant model of abnormalities in mental development in the offspring.   This is a widely used model of the effect of maternal stress on the next generation that has been established in many species, including nonhuman primates. Sadly, maternal stress was shown tightly associated with the mental state of human children as well.” 

“Our paper implies no human health risk,” Hammock pointed out. “This was a very high dose of glyphosate, actually close to acute toxicity. This is stress, and the bioassay is the effect of stress in the dam on the pups. The paper shows that with massive doses of glyphosate to the dams for long periods in the maternal stress model that glyphosate causes behavioral abnormalities in the pups.”

“Such studies are important to generate hypotheses of environmental risk,” said Hammock, who meshes his expertise in chemistry, toxicology, biochemistry and entomology, in his 50-year research to find a non-addictive drug to control chronic pain. “Because we only saw maternal immune stress at exceptionally high doses of glyphosate, our data fail to support the hypothesis that glyphosate exposure causes autism with expected dietary, environmental or even occupational exposure.”

The research drew financial support from the Japan Society for the Promotion of Science (to Hashimoto); and the National Institute of Environmental Health Sciences (NIEHS) River Award (to Hammock), and NIEHS Superfund Program (to Hammock). Hammock has directed the UC Davis Superfund Program for nearly four decades.

The Hashimoto-directed Chiba group has shown that these drug candidates prevent and even reverse a variety of chronic diseases of the central nervous system in mice and human cells including ASD like behaviors.   

The 16 co-authors include Hammock lab researchers Jun Yang, Sung Hee Hwang and Debin Wan. 

Yang said that the researchers “hypothesized that the role of the sEH is important in the pathogenesis of ASD in offspring after maternal glyphosate exposure based on our previous finding that sEH plays a key role in the development of ASD-like behavioral abnormalities in juvenile offspring after maternal immune activation (MIA), a prenatal environmental factor.”

Said Hwang: “Some epidemiological studies suggest an association between glyphosate use in agriculture and increases in autism like disorders. The doses we used in mice were so high that we fail to support glyphosate epidemiological associations between the herbicide use and the cause ASD-like behaviors. 

The PNAS abstract:

“Epidemiological studies suggest that exposure to herbicides during pregnancy might increase risk for autism spectrum disorder (ASD) in offspring. However, the mechanisms underlying the risk of ASD by herbicides such as glyphosate remain unclear. Soluble epoxide hydrolase (sEH) in the metabolism of polyunsaturated fatty acids is shown to play a key role in the development of ASD in offspring after maternal immune activation. Here, we found ASD-like behavioral abnormalities in juvenile offspring after maternal exposure to high levels of formulated glyphosate. 

“Furthermore, we found increases in sEH in the prefrontal cortex (PFC), hippocampus, and striatum of juvenile offspring and oxylipin analysis showed decreased levels of epoxy-fatty acids such as 8(9)-EpETrE in the blood, PFC, hippocampus, and striatum of offspring after maternal glyphosate exposure, supporting increased activity of sEH in the offspring. Moreover, we report abnormal composition of gut microbiota and short chain fatty acids in fecal samples of juvenile offspring after maternal glyphosate exposure. Interestingly, oral administration of TPPU (an sEH inhibitor) to pregnant mothers from E5 to P21 prevented ASD-like behaviors such as social interaction deficits and increased grooming time in the juvenile offspring. These findings suggest that maternal exposure to high levels of glyphosate causes ASD-like behavioral abnormalities and abnormal composition of gut microbiota in juvenile offspring, and that increased activity of sEH might play a role in ASD-like behaviors in offspring after maternal glyphosate exposure. Therefore, sEH may represent a target for ASD in offspring after maternal stress from occupational exposure to contaminants.  

“Maternal exposure to high levels of the herbicide glyphosate may increase the risk for autism spectrum disorder (ASD) in offspring; however, the underlying mechanisms remain largely unknown. Maternal glyphosate exposure during pregnancy and lactation caused ASD-like behavioral abnormalities and abnormal composition of gut microbiota in murine male offspring. Soluble epoxide hydrolase (sEH) in the brain of offspring after maternal glyphosate exposure was higher than controls. Treatment with an sEH inhibitor from pregnancy to weaning prevented the onset of ASD-like behavioral abnormalities in offspring after maternal glyphosate exposure. The glyphosate exposures used here exceed any reasonable dietary, environmental or occupational exposure, but they indicate that increased sEH plays a role in ASD-like behaviors in offspring.”