- Author: Kathy Keatley Garvey
Water warriors Bruce Hammock, distinguished professor of entomology with a joint appointment with the UC Davis Comprehensive Cancer Center, and research scientist Christophe Morisseau of the Hammock lab proved to be “The Splash Brothers,” much like basketball superstars Steph Curry and Klay Thompson of the Golden State Warriors.
But they did it with water balloons, not with a basketball.
It was all part of the 13th annual Hammock Lab Water Balloon Battle, dubbed “Balloon Battle at Briggs” last Friday afternoon. The 40 participants, including professors, researchers, graduate students, staff, students and family members, tossed 3000 water balloons in 15 minutes on the thirsty Briggs Hall lawn, as the temperature soared to 97 degrees. As the supply dwindled, they dumped the remaining water from the buckets on each other.
A highlight: “Splash Sister” Alifia Merchant of the Hammock lab, who just received her master's degree in agriculture and environmental chemistry, managed to sneak up on Hammock and drench him.
Hammock launched the annual event in 2003 as a form of camaraderie and as a means of rewarding the lab members for their hard work. The international Hammock lab includes 7 researchers, 9 postdoctorates, 3 graduate students, 10 visiting scholars, 3 staff and 1 undergrad. They represent Barbados, Canada, China, France, Germany, Hong Kong, India, Japan, Korea, Sweden, Thailand, Turkey, United States, Ukraine and Uruguay.
When UC Davis police officer Stephen Jerguson passed by on foot, he was invited to join in on the fun. Seven-year-old Jasmine Morisseau, daughter of Christophe Morisseau, handed him a water balloon for safe-keeping as he watched the fun-in-the-sun event from the sidelines. At the end of the battle, he handed it back to her. He then joined the group in cleaning up the balloon remnants.
Hammock, a member of the National Academy of Sciences and a fellow of the National Academy of Inventors, directs the campuswide Superfund Research and Training Program, an interdisciplinary program funded by the National Institute of Environmental Sciences (NIEHS) that has brought in almost $60 million to the UC Davis campus. The Hammock lab is also the home of the National Institutes of Health Training Grant in Biomolecular Technology. The lab alumni, totaling more than 100 graduates, hold positions of distinction in academia, industry and government as well as more than 300 postdoctorates.
The “Balloon Battle at Briggs” was canceled last year due to the severity of the California drought.
In 2014, the water warriors took drought-conservation precautions as they did this year.
“We devised a filling station out of drip line and valves so we could fill the balloons outside and also turn off the water when not in use,” said Hammock lab program manager Cindy McReynolds. “Water conservation was a big topic surrounding the (2014) event, so we also used it as an opportunity to discuss ways we have changed our daily routines to conserve water."
As an extra bonus, the annual battle provides a little water for the thirsty Briggs Hall lawn, which is used by campus wildlife, including ducks, turkeys, squirrels, birds, butterflies and bees.
- Author: Kathy Keatley Garvey
The research, published March 14 in the journal Proceedings of the National Academy of Sciences, involves studies of an inhibitor of soluble epoxide hydrolase in rodents. Soluble epoxide hydrolase, or sEH, is emerging as a therapeutic target that acts on a number of inflammatory or inflammation-linked diseases.
“The research in animal models of depression suggests that sEH plays a key role in modulating inflammation, which is involved in depression,” said Hammock, a distinguished professor of entomology with a joint appointment at the UC Davis Comprehensive Cancer Center. “Inhibitors of sEH protect natural lipids in the brain that reduce inflammation, and neuropathic pain. Thus, these inhibitors could be potential therapeutic drugs for depression.”
They found that TPPU displayed rapid effects in both inflammation and social defeat-stress models of depression. Expression of sEH protein was higher in key brain regions of chronically stressed mice was higher than in control mice, they found.
“Most drugs for psychiatric diseases target how neurons communicate; here we are targeting the wellness and environment of the neurons,” said UC Davis researcher Christophe Morisseau.
The researchers also discovered that postmortem brain samples of patients with psychiatric diseases, including depression, bipolar disorder, and schizophrenia, showed a higher expression of sEH than controls.
The researchers found that pretreatment with TPPU prevented the onset of depression-like behaviors in mice after induced inflammation or repeated social-defeat stress. Mice lacking the sEH gene did not show depression-like behavior after repeated social-defeat stress.
“All these findings suggest that sEH plays a key role in the pathophysiology of depression and that epoxyfatty acids, and their mimics as well as sEH inhibitors, are potential therapeutic or prophylactic drugs for depression,” Hashimoto said.
Robert E. Hales, distinguished professor of clinical psychiatry and the Joe P. Tupin Endowed Chair of the Department of Psychiatry and Behavioral Sciences at UC Davis School of Medicine, said new medication treatment approaches are needed to treat depression. Hales, who was not involved in the research, said the new paper represents “an important and novel approach to treating depression.”
“With lifetime prevalence rates of major depressive disorder being in the range of 16 percent and with nearly two-thirds of patients failing to respond to pharmacologic treatments, there is a pressing need to discover new medication treatment approaches,” Hales said. “Their findings lend support to the potential use of TPPU, a sEH inhibitor, as a new therapeutic medication to prevent and treat depression.”
Other authors on the paper are: Qian Ren, Min Ma, Tamaki Ishima, Ji-chun Zhang, Chun Yang, Wei Yao, Chao Dong, and Mei Han, Chiba University; and Jun Yang at UC Davis.
Morisseau, Yang and Wagner are inventors on University of California patents related to soluble epoxide hydrolase. Some of these patents have been licensed by EicOsis Human Health, a Davis company founded by Hammock to develop pharmaceuticals to alleviate neuropathic and inflammatory pain.
The research was funded by Grant-in-Aid for Scientific Research on Innovative Areas of the Ministry of Education, Culture, Sports, Science and Technology, Japan to Kenji Hashimoto, (#24116006), and a Research Fellowship for Young Scientists of the Japan Society for the Promotion of Science (Tokyo, Japan) to Qian Ren.
Partial support was provided by the National Institute of Environmental Health Sciences (NIEHS) R01 ES002710, NIEHS Superfund Research Program grant P42 ES004699, and NIH U24 DK097154 West Coast Comprehensive Metabolomics Center.
Hammock and Professor Bruce German, UC Davis recently received a National Institutes of Health grant in collaboration with Pei-an Shih, UC San Diego Department of Psychiatry, to investigate the role of bioactive lipids in a related psychiatric disorder, anorexia nervosa.
- Author: Kathy Keatley Garvey
Bruce's Big Battle at Briggs, which draws professors, researchers, visiting scientists, postdoctoral scholars, graduate students and undergraduate students and their friends and families, showcases what the internationally known Hammock lab does for camaraderie and fun.
The event amounts to a 10-minute break from their 52 weeks of scientific work.
The water warriors are so proficient that the event actually spans about 8 to 9 minutes, said organizer Christophe Morisseau, associate research scientist.
Hammock, a distinguished professor of entomology who holds a joint appointment with the UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center, launched the water balloon fest in 2003 as a way to build camaraderie and gain relief from the heat. Temperatures soared to 98 degrees on Thursday, July 24, the afternoon of the battle.
For the occasion, the water warriors first filled 2000 small water balloons on the Briggs Hall lawn.
“We did try filling the balloons differently this year to conserve water,” said Hammock lab program manager Cindy McReynolds. “We devised a filling station out of drip line and valves so we could fill the balloons outside and also turn off the water when not in use.”
Thirty-nine people comprise the Hammock lab: 11 postdoctoral fellows, 8 research staff, 7 visiting scholars, 4 graduate students, 4 undergraduates, 4 staff and one part-time student assistant.
The Hammock lab has always enjoyed an international presence. Of the researchers this year, 8 are from China, 3 from France, 2 from Hong Kong, 2 from the Ukraine, and 1 each from India, Japan and Canada.
“They caught on quickly,' said Louisa Suet Yi Lo, administrative assistant. “It didn't take long for them to warm up and they really enjoyed dousing each other, especially the big boss, Bruce Hammock.”
"It was great seeing everyone relaxing and having so much fun," said Grace Bedoian of the administrative staff who will be retiring July 30. "They work hard and they play hard.”
Hammock, a member of the National Academy of Sciences and a fellow of the Entomological Society of America, directs the campuswide Superfund Research Program, National Institutes of Health Biotechnology Training Program, and the National Institute of Environmental Health Sciences (NIEHS) Combined Analytical Laboratory.
As an extra bonus, the annual battle provides a little water for the thirsty Briggs Hall lawn, which is used by campus wildlife, including ducks, turkeys, squirrels, birds, butterflies and bees.
- Author: Kathy Keatley Garvey
The 12th annual Bruce Hammock Lab Water Balloon Battle will take place at 3 p.m., Thursday, July 24 on the north side of the Briggs Hall lawn.
Christophe Morisseau, associate research scientist, said the lab has 2000 water balloons to fill; anyone who wants to be a water warrior must participate in the filling, which starts at 1 p.m. by the Briggs loading dock.
All are invited. “Whoever wants to get wet,” Morisseau said. “Children and spouses are always welcome.”
In the past, the water warriors, led by Bruce Hammock and Morisseau, have included professors, researchers, visiting scientistis, postdoctoral scholars, graduate students and undergraduate students.
In addition to the water balloons, some favor squirt guns and toy pressurized water blasters. Others hoist half-filled buckets of water for sneak attacks.
So proficient are the water warriors that the “15 minutes of fame” often turns into “10 minutes of aim.”
Hammock, a distinguished professor of entomology who holds a joint appointment with the UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center, launched the water balloon fest in 2003 as a way to build camaraderie and gain relief from the heat.
The Hammock lab works hard and plays hard. Hammock, a member of the National Academy of Sciences and a fellow of the Entomological Society of America, directs the campuswide Superfund Research Program, National Institutes of Health Biotechnology Training Program, and the National Institute of Environmental Health Sciences (NIEHS) Combined Analytical Laboratory.
- Author: Kathy Keatley Garvey
The 11th annual Bruce Hammock Lab Water Balloon Battle will take place starting at 3 p.m. on Friday, July 12 on the Briggs Hall lawn, the north side of the building.
Organizer Christophe Morisseau of the Hammock lab invites all to "join us for our traditional fun."
But, "no filling, no throwing," he said.
Participants will fill 2000 water balloons starting at 1:15 p.m. in Room 82 of Briggs Hall.
Folks are also invited to participate and/or "come and watch."
When all the balloons have been tossed, it's traditional to fill up bins of water and heave them at unsuspecting water warriors.
Hammock, a distinguished professor of entomology who has a joint appointment with the UC Davis Comprehensive Cancer Center, launched the water balloon fest in 2003 as a way to build camaraderie and gain relief from the heat. The water warriors usually toss all the balloons within 15 minutes, a feat known as "15 Minutes of Aim!"
The Hammock lab is known for working hard and playing hard. Hammock directs the campuswide Superfund Research Program, the National Institutes of Health Biotechnology Training Program and the NIEHS Combined Analytical Laboratory. He is a Fellow of the Entomological Society of America, a member of the prestigious National Academy of Sciences, and the recipient of the Distinguished Teaching Award for Graduate and Professional Teaching in 2008 and the UC Davis Faculty Research Lecture Award in 2001.
More information on the water balloon battle is available from Morisseau at (530) 752-6571 or at chmorisseau@ucdavis.edu.