- Author: Kathy Keatley Garvey
The drug candidate, known as EC5026, targets a novel pathway to block the underlying cause of certain types of pain. Described by EicOsis as a “novel, non-opioid and oral therapy for neuropathic and inflammatory pain,” it is an inhibitor to the soluble epoxide hydrolase (sEH) enzyme, a key regulatory enzyme involved in the metabolism of fatty acids. UC Davis recently licensed certain patents supporting the underlying technology exclusively to EicOsis.
Clinical trials are expected to begin this summer. “The clinical trials would be the world's first clinical evaluation of sEH for pain,” said William Schmidt, EicOsis vice president of clinical development, who has focused his entire professional career on developing novel pain medicines. “I am thrilled that we have a drug candidate lacking the side effects of both opioids and non-steroidal anti-inflammatory drugs that can potentially produce lead to an entirely new way to treat chronic pain.”
“Chronic pain is an enormous emotional and economic burden for more than 100 million people in the United States alone,” said Hammock, a UC Davis a distinguished professor who holds a joint appointment with the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. He co-founded EicOsis in December 2011 to alleviate pain in humans and companion animals. “The extreme and poorly treated pain that I observed as a medical officer working in a burn clinic in the Army, is a major driver for me to translate my research to help patients with severe pain.”
National statistics show that as many as eight out of every 10 American adults suffer from chronic pain; three out of four patients consider their therapies for pain ineffective; and as many as a third of the opioid-prescribed patients misuse them.
Every day, more than 130 people in the United States die from opioid overdose, according to the National Institute of Drug Abuse. The Centers for Disease Control and Prevention estimates that the total economic burden of prescription opioid misuse alone in the United States is $78.5 billion a year. That includes the costs of health care, lost productivity, addiction treatment, and criminal justice involvement.
“This completes the fundraising for Phase 1 of the clinical development program of this novel pain therapeutic,” said Hammock. “We are particularly pleased that the support came from Open Philanthropy with its history of both financially successful and socially important investments.”
Dushyant Pathak, UC Davis associate vice chancellor for Research and executive director of Venture Catalyst, lauded the achievement. “We are very pleased to see the achievement of this important business milestone by EicOsis,” Pathak said. “It's especially heartening to see the entrepreneurial persistence of Bruce Hammock being recognized by Open Philanthropy.”
Open Philanthropy identifies outstanding investment opportunities and makes grants based on importance, need, and tractability, according to the organization's scientific advisors Chris Somerville and Heather Youngs. They said Open Philanthropy selected the Davis project because the EicOsis drug “may reduce suffering from chronic pain conditions which are severe in both developed and developing nations.”
On its website, http://www.eicosis.com, EicOsis depicts itself as “a privately held company developing a first-in-class therapy of a once daily, oral treatment for neuropathic and inflammatory pain in humans and companion animals.”
“Our orally active compounds stabilize natural regulatory mediators in the body that reduce endoplasmic reticulum stress, which, in turn, appears to cause a variety of chronic diseases,” said EicOsis neurobiologist Karen Wagner. “The EicOsis compounds represent a new mechanism of action that both resolves inflammation and reduces pain.”
EicOsis (pronounced eye-cosis), derives its name from eicosanoid, “the major backbone of chemical mediators in the arachidonate cascade,” said Cindy McReynolds, an EicOsis project manager and a doctoral student in pharmacology and toxicology at UC Davis. “It symbolizes the epoxide group in chemistry, which is key to the anti-inflammatory chemical mediators and where the biochemical target called soluble epoxide hydrolase works.”
The National Institutes of Health (NIH) Blueprint for Neuroscience Research (Blueprint) awarded EicOsis a $4 million grant to advance compounds through Phase 1 clinical trials for diabetic neuropathic pain. A goal of the Blueprint Neurotherapeutics Network is to discover, develop and generate novel compounds that will ultimately be commercialized and benefit humankind.
In addition, EicOsis received support from the NIH's National Institute of Neurological Disorders and Stroke (NINDS), and the support of two small business programs affiliated with the National Institute of Environmental Sciences: the Small Business Innovation Research (SBIR) and the Small Business Technology Transfer (STTR).
“We are fortunate to receive all this support in the development of our oral medication for pain treatment through human Phase 1a trials, and now Open Philanthropy through human Phase 1b trials and beyond,” said Alan Buckpitt, a UC Davis retired professor of veterinary pharmacology and toxicology, and a principal investigator on the grants.
Nationally recognized for his achievements, Hammock is a fellow of the National Academy of Inventors, which honors academic invention and encourages translations of inventions to benefit society. He is a member of the U.S. National Academy of Sciences, a fellow of the Entomological Society of America, and the recipient of scores of awards, including the first McGiff Memorial Awardee in Lipid Biochemistry; and the Bernard B. Brodie Award in Drug Metabolism, sponsored by the America Society for Pharmacology and Experimental Therapeutics.
Hammock, a member of the UC Davis faculty since 1980, received his doctorate in entomology and toxicology from UC Berkeley. He traces the history of his enzyme research to 1969 during his graduate student days in the John Casida laboratory. Hammock was researching insect developmental biology and green insecticides when he and colleague Sarjeet Gill, now a distinguished professor at UC Riverside, discovered the target enzyme in mammals that regulates epoxy fatty acids.
“My research led to the discovery that many regulatory molecules are controlled as much by degradation and biosynthesis,” Hammock said. “The epoxy fatty acids control blood pressure, fibrosis, immunity, tissue growth, depression, pain and inflammation to name a few processes.”
“Basically, I began by trying to figure out how a key enzyme, epoxide hydrolase, degrades a caterpillar's juvenile hormone, leading to metamorphosis from the larval stage to the adult insect,” Hammock. He asked himself these questions: “Does the enzyme occur in plants? Does it occur in mammals?" It does, and particularly as a soluble epoxide hydrolase in mammals.
"It is always important to realize that the most significant translational science we do in the university is fundamental science,” said Hammock, marveling that “this all began by asking how caterpillars turn into butterflies.”
- Author: Kathy Keatley Garvey
CBP supports students engaged in pre-doctoral training at the chemistry-biology interface, preparing them for careers in the biomedical workforce. McReynolds is one of four students selected for the 2017-18 CBP training grant program.
“We are very proud of her,” said Hammock, distinguished professor of entomology, UC Davis Department of Entomology and Nematology, who holds a joint appointment with the UC Davis Comprehensive Cancer Center.
A member of the Pharmacology and Toxicology Graduate Group, McReynolds focuses her research on “developing chemical tools to elucidate the biological relevance of chemical compounds (dihydroxy diols) in biological systems.”
Hammock is her major professor. "Cindy has more than 12 years of experience in research and project management, extensive research experience and advanced knowledge of drug development,” Hammock said.
Prior to enrolling in the doctoral program, McReynolds served as the program administrator of UC Davis/National Institute of Environmental Health Sciences Superfund Research Program, directed by Hammock. She is the project manager of EicOsis, a Davis-based company founded by Hammock to develop a small molecule inhibitor to treat pain in humans and animals.
A native of Louisville, KY, McReynolds received her bachelor of science degree in animal science from UC Davis in 1999, and her master's degree in animal science in 2001 from Washington State University, Pullman, Wash., where she was named Outstanding Graduate Student, Teaching Assistant of the Year and recipient of the Dr. Ralph Erb Outstanding Graduate Student Award. Her master's thesis involved how dietary carotenoids inhibit tumor growth.
McReynolds then joined a project development team at Celera Corporation--an Alameda-based company involved in genetic sequencing and related technologies--that led to the selection of Vorinostat, a cancer treatment. She served as a team leader of the Tumor Development Team at Celera, tasked with developing new models of drug-resistant cancer and analyzing newly generated data from the Human Genome Project to identify new cancer therapies.
- Author: Kathy Keatley Garvey
The 14th annual Bruce Hammock Lab Water Balloon Battle that took place on the Briggs Hall lawn, University of California, Davis, amounted to “fifteen minutes of aim” as academics and their families gleefully tossed 2000 balloons in 15 minutes as the temperature soared into the 90s.
When the water warriors depleted their supply, they drenched their fellow warriors with excess water from the buckets and other containers.
Bruce Hammock, UC Davis distinguished professor who holds a joint appointment with the UC Davis Department of Entomology and Nematology and the Comprehensive Cancer Center, managed to drench colleague Aldrin Gomes, associate professor of neurobiology, physiology and behavior, in a one-on-one soakfest.
“That was me losing Aldrin's friendship,” Hammock quipped of his four-year friendship. Hammock's office is headquartered on the ground or “garden” level of Briggs, and Gomes, on the first floor.
“Aldrin is one of our UC Davis star scientists,” Hammock said. “He works on heart failure and heart mitochondria. He's a very good guy. He has just been funded as part of the UC Davis Superfund Program (which Hammock directs).”
The water balloon battle usually draws some 50 fun/camaraderie seekers, including professors, researchers, graduate students, staff, students and family members. Hammock lab researcher Christophe Morisseau, who coordinates the traditional event, said participants first fill the water balloons near the Briggs loading dock, or “they BYOB” (bring your own balloons).
The thirsty Briggs Hall lawn benefits as do the fun seekers. The participants pick up the balloon remnants before returning to work.
The international Hammock lab and office includes personnel from Canada, Ukraine, France, China, Sweden, Japan, Germany, Korea, Uruguay and the Netherlands, besides the United States. They are post docs, researchers, graduate students, visiting scholars, visiting graduate students, visiting summer students, short-term visiting scholars and student interns.
Highly honored by his peers (but a target at the annual water balloon battle), Hammock is a fellow of the National Academy of Inventors, which honors academic invention and encourages translations of inventions to benefit society. He is a member of the U.S. National Academy of Sciences, a fellow of the Entomological Society of America, and the recipient of the Bernard B. Brodie Award in Drug Metabolism, sponsored by the America Society for Pharmacology and Experimental Therapeutics. He directs the campuswide Superfund Research Program, National Institutes of Health Biotechnology Training Program, and the National Institute of Environmental Health Sciences (NIEHS) Combined Analytical Laboratory.
- Author: Kathy Keatley Garvey
Water warriors Bruce Hammock, distinguished professor of entomology with a joint appointment with the UC Davis Comprehensive Cancer Center, and research scientist Christophe Morisseau of the Hammock lab proved to be “The Splash Brothers,” much like basketball superstars Steph Curry and Klay Thompson of the Golden State Warriors.
But they did it with water balloons, not with a basketball.
It was all part of the 13th annual Hammock Lab Water Balloon Battle, dubbed “Balloon Battle at Briggs” last Friday afternoon. The 40 participants, including professors, researchers, graduate students, staff, students and family members, tossed 3000 water balloons in 15 minutes on the thirsty Briggs Hall lawn, as the temperature soared to 97 degrees. As the supply dwindled, they dumped the remaining water from the buckets on each other.
A highlight: “Splash Sister” Alifia Merchant of the Hammock lab, who just received her master's degree in agriculture and environmental chemistry, managed to sneak up on Hammock and drench him.
Hammock launched the annual event in 2003 as a form of camaraderie and as a means of rewarding the lab members for their hard work. The international Hammock lab includes 7 researchers, 9 postdoctorates, 3 graduate students, 10 visiting scholars, 3 staff and 1 undergrad. They represent Barbados, Canada, China, France, Germany, Hong Kong, India, Japan, Korea, Sweden, Thailand, Turkey, United States, Ukraine and Uruguay.
When UC Davis police officer Stephen Jerguson passed by on foot, he was invited to join in on the fun. Seven-year-old Jasmine Morisseau, daughter of Christophe Morisseau, handed him a water balloon for safe-keeping as he watched the fun-in-the-sun event from the sidelines. At the end of the battle, he handed it back to her. He then joined the group in cleaning up the balloon remnants.
Hammock, a member of the National Academy of Sciences and a fellow of the National Academy of Inventors, directs the campuswide Superfund Research and Training Program, an interdisciplinary program funded by the National Institute of Environmental Sciences (NIEHS) that has brought in almost $60 million to the UC Davis campus. The Hammock lab is also the home of the National Institutes of Health Training Grant in Biomolecular Technology. The lab alumni, totaling more than 100 graduates, hold positions of distinction in academia, industry and government as well as more than 300 postdoctorates.
The “Balloon Battle at Briggs” was canceled last year due to the severity of the California drought.
In 2014, the water warriors took drought-conservation precautions as they did this year.
“We devised a filling station out of drip line and valves so we could fill the balloons outside and also turn off the water when not in use,” said Hammock lab program manager Cindy McReynolds. “Water conservation was a big topic surrounding the (2014) event, so we also used it as an opportunity to discuss ways we have changed our daily routines to conserve water."
As an extra bonus, the annual battle provides a little water for the thirsty Briggs Hall lawn, which is used by campus wildlife, including ducks, turkeys, squirrels, birds, butterflies and bees.
- Author: Kathy Keatley Garvey
That's about all it takes to toss 2000 water balloons.
The annual event, coordinated by researcher Christophe Morisseau of the Hammock lab, begins at 3 p.m., Friday, July 22 on the north lawn of Briggs Hall, Kleiber Hall Drive.
Tabbed the alliterative "Bruce's Big Battle at Briggs," the water balloon battle draws professors, researchers, visiting scientists, postdoctoral scholars, graduate students and undergraduate students and their friends and families in showcasing what the internationally known Hammock lab does for camaraderie and fun.
Temperatures are expected to reach 97 degrees.
Hammock, a distinguished professor of entomology who holds a joint appointment with the UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center, launched the water balloon fest in 2003 as a way to build camaraderie and gain relief from the heat.
A member of the National Academy of Sciences and a fellow of the National Academy of Inventors, he directs the campuswide Superfund Research and Training Program, an interdisciplinary program funded by the National Institute of Environmental Sciences (NIEHS) that has brought in almost $60 million to the UC Davis campus. The Hammock lab is also the home of the National Institutes of Health Training Grant in Biomolecular Technology. The lab alumni, totaling more than 100 graduates, hold positions of distinction in academia, industry and government as well as more than 300 postdoctorates.
Balloon filling starts at 1:15 in Room 82 of Briggs Hall. All are invited to participate, but "no filling/no throwing," Morisseau said. Many are expected to watch.
The event was canceled last year due to the severity of the drought.
In 2014, the water warriors took drought-conservation precautions.
“We did try filling the balloons differently this year to conserve water,” Hammock lab program manager Cindy McReynolds said that year. “We devised a filling station out of drip line and valves so we could fill the balloons outside and also turn off the water when not in use. Water conservation was a big topic surrounding the event, so we also used it as an opportunity to discuss ways we have changed our daily routines to conserve water."
As an extra bonus, the annual battle provides a little water for the thirsty Briggs Hall lawn, which is used by campus wildlife, including ducks, turkeys, squirrels, birds, butterflies and bees.