His talk, free and open to the public, is sponsored by the UC Davis Emeriti Association and the UC Davis Retirees' Association.
“Honey bees exhibit complex social behavior that rivals our own,” Page says. “It is fundamentally bound within a social contract much like ours that makes the basic social structure inescapable, a consequence of living together in family groups. Social structures evolve by natural selection operating on the final product, the colony as a reproductive unit. The structures themselves are reverse engineered.”
“I will show how selection on the economy of the colony shapes structures from nest and social architecture to gene networks.”
Page is a UC Davis Distinguished Emeritus Professor, an honor awarded in January; and a Regents Professor Emeritus and University Provost Emeritus from Arizona State University, Tempe. He retired from UC Davis in May 2004 after chairing the Department of Entomology, now the Department of Entomology and Nematology.
Born and reared in Bakersfield, Kern County, Rob received his bachelor's degree in entomology, with a minor in chemistry, from San Jose State University in 1976. After obtaining his doctorate from UC Davis in 1980, he served as assistant professor at The Ohio State University before joining the UC Davis entomology faculty in 1989 as an associate professor. He began working closely with Harry H. Laidlaw Jr., (the father of honey bee genetics) for whom the university's bee facility is named. Together they published many significant research papers.
Page chaired the Department of Entomology from 1999 to 2004, when Arizona State University recruited him to be the founding director of the School of Life Sciences of Arizona State University (ASU). His ASU career advanced to dean of Life Sciences; vice provost and dean of the College of Liberal Arts and Sciences; and university provost.
Page is known for his research on honey bee behavior and population genetics, particularly the evolution of complex social behavior. One of his most salient contributions to science was to construct the first genomic map of the honey bee, which sparked a variety of pioneering contributions not only to insect biology but to genetics at large.
At UC Davis, he maintained a honey bee-breeding program for 24 years, from 1989 to 2015, managed by bee breeder-geneticist Kim Fondrk at the Harry H. Laidlaw Jr. Honey Bee Research Facility. They discovered a link between social behavior and maternal traits in bees. Their work was featured in a cover story in the journal Nature. In all, Nature featured his work on four covers from work mostly done at UC Davis.
Page and his lab pioneered the use of modern techniques to study the genetic basis of social behavior evolution in honey bees and other social insects. He was the first to employ molecular markers to study polyandry and patterns of sperm use in honey bees. He provided the first quantitative demonstration of low genetic relatedness in a highly eusocial species.
His work has garnered a significant impact in the scientific community through his research on the evolutionary genetics and social behavior of honey bees. He was the first to demonstrate that a significant amount of observed behavioral variation among honey bee workers is due to genotypic variation. In the 1990s, he and his students and colleagues isolated, characterized and validated the complementary sex determination gene of the honey bee; considered the most important paper yet published about the genetics of Hymenoptera. The journal Cell featured their work on its cover. In subsequent studies, he and his team published further research into the regulation of honey bee foraging, defensive and alarm behavior.
Page has authored than 250 research papers, including five books: among them “The Spirit of the Hive: The Mechanisms of Social Evolution,” published by Harvard University Press in 2013. He is a highly cited author on such topics as Africanized bees, genetics and evolution of social organization, sex determination, and division of labor in insect societies. His resume shows more than 18,000 citations.
Highly honored by his peers, Page is a fellow of a number of organizations, including the American Association for the Advancement of Science, the California Academy of Sciences, the Entomological Society of America, and organizations in Germany and Brazil. He received the Alexander von Humboldt Senior Scientist Award, known at the Humboldt Prize, the highest honor given by the German government to foreign scientists. He received the 2018 Thomas and Nina Leigh Distinguished Alumni Award from UC Davis Department of Entomology and Nematology.
The UC Davis Retiree Center periodically holds noon educational seminars ("BrainFood Talks") featuring timely speakers. For more information, contact the UC Davis Retiree Center at (530) 752-5182 or firstname.lastname@example.org.
Boudinot co-led the development of the collection with István Mikó, collections manager at the University of New Hampshire Department of Biological Sciences.
For the year-long project. Boudinot and Mikó gathered articles illustrating cutting-edge research techniques in insect morphology and phylogenetics, including videos, interactive 3D images, and augmented reality.
"The increasing availability of advanced technologies, such as micro-computed tomography and confocal laser scanning microscopy, are allowing researchers to generate models of morphology in three and four dimensions based on physical data,” Boudinot wrote in the foreword. “These models not only allow for detailed and quantitative study of anatomical systems and their biomechanical properties, but they also allow end-users to experience the richness of morphology in virtual reality, which is incredible."
Boudinot marvels at the 3D models “which open new pathways of research and which you can manipulate on your computer, and another which can project your model in virtual reality on your phone or tablet.”
Boudinot also wrote an editorial on the future of morphology titled Toward Phylomics in Entomology: Current Systematic and Evolutionary Morphology.
Articles in the collection include:
- A Systematist's Guide to Estimating Bayesian Phylogenies From Morphological Data
- PARAMO: A Pipeline for Reconstructing Ancestral Anatomies Using Ontologies and Stochastic Mapping
- From Spinning Silk to Spreading Saliva: Mouthpart Remodeling in Manduca sexta (Lepidoptera: Sphingidae)
- Jumping and Grasping: Universal Locking Mechanisms in Insect Legs
- Revision of the Highly Specialized Ant Genus Discothyrea (Hymenoptera: Formicidae) in the Afrotropics with X-Ray Microtomography and 3D Cybertaxonomy
- Ready Species One: Exploring the Use of Augmented Reality to Enhance Systematic Biology with a Revision of Fijian Strumigenys (Hymenoptera: Formicidae)
Boudinot said the six papers “span an arc from integrated methods of phenotype observation and visualization to methods and background for phylogenetic modeling of morphological characters.” In his editorial, he reviewed “the central role of anatomical classification and anatomical terminology in systematic by way of outlining the special collection. I argue ultimately for a reconceptualization of phylogenetic morphology.”
Boudinot coined the word, “Phylomics,” which he said “can be defined as the inference of organismal evolution at the molecular and morphological scale, through the use of genomic and phenomic data (the ‘phenome' being a physical model of the phenotype of an organism, such as seen in the ISD special collection). The idea ultimately is to model the morphology of organisms across the phylogeny, through time, literally depicting ancestors and seeing the transformation from ancestor to descendant across the tree of life.”
UC Davis undergraduate student Ziv Lieberman of the Phil Ward lab (he's a senior majoring in evolution and ecology), and Francisco Hita-Garcia of Okinawa (of the Biodiversity and Biocomplexity Unit and Institute of Science and Technology Graduate University), served as the lead authors of “Revision of the Highly Specialized Ant Genus Discothyrea (Hymenoptera: Formicidae) in the Afrotropics with X-Ray Microtomography and 3D Cybertaxonomy.”
Lieberman and Hita-Garcia and three other co-authors described 15 new species in the genus, which is poorly represented in museum collections. Due to its “cryptic lifestyle, Discothyrea are poorly represented in museum collections and their taxonomy has been severely neglected,” they wrote. “We perform the first comprehensive revision of Discothyrea in the Afrotropical region through a combination of traditional and three-dimensional (3D) cybertaxonomy based on microtomography (micro-CT). Species diagnostics and morphological character evaluations are based on examinations of all physical specimens and virtual analyses of 3D surface models generated from micro-CT data.” These models can be seen for free in their article and online at https://sketchfab.com/arilab/collections/discothyrea.
Additionally, they applied “virtual dissections for detailed examinations of cephalic structures to establish terminology based on homology for the first time in Discothyrea. The complete datasets comprising micro-CT data, 3D surface models and videos, still images of volume renderings, and colored stacked images are available online as cybertype datasets (Hita Garcia et al. 2019, http://doi.org/10.5061/dryad.3qm4183).”
The journal, Insect Systematics and Diversity, launched by ESA in 2017, publishes research on systematics, evolution, and biodiversity of insects and related arthropods, including comparative and developmental morphology, conservation, behavior, taxonomy, molecular phylogenetics, paleobiology, natural history, and phylogeography.
The journal set out to host articles that utilize novel technologies or data types or describe emerging methods of research, ESA spokesperson Lisa Junker said. The new special collection on current techniques in morphology, she said, highlights how Insect Systematics and Diversity has become a premier outlet for integrative research combining multiple subdisciplines within the field.
EicOsis LLC, a company founded by UC Davis distinguished professor Bruce Hammock to develop a non-opiate drug to relieve inflammatory pain in companion animals and target chronic neuropathic pain in humans and horses, can now add “Sacramento Region Innovator of the Year” to its list of accomplishments.
EicOsis won the award in the medical health/biopharmaceutical category of the annual Sacramento Region Innovation Awards Program. The program “recognizes the area's vibrant innovation community—from emerging to established companies—and their breakthrough creations,” according to sponsors Stoel Rives LLP, Moss Adams LLP and the Sacramento Business Journal.
“This project is an illustration of how fundamental science leads to real world applications, in this case addressing severe pain of humans and companion animals,” said Hammock, chief executive officer of EicOsis and a UC Davis faculty member who holds a joint appointment with the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. “Our success in translation has been due largely to support from a number of institutes of the National Institutes of Health and a small team of hard-working scientists.”
The ceremony, honoring the winners of the eight categories, took place Nov. 7 in the Crest Theatre, Sacramento. Judges scored the finalists on novelty, market need, economic or social impact and disruption.
“It was an honor to be awarded the Sacramento Region Innovator of the Year in Medical Health and BioPharma,” said Cindy McReynolds, senior program manager of EicOsis and a UC Davis doctoral candidate studying pharmacology and toxicology. “The companies represented were inspiring, and it is great to be a part of the innovation going on in the Sacramento region.”
“Chronic pain is an enormous emotional and economic burden for more than 100 million people in the United States alone,” said Hammock, who co-founded EicOsis in December 2011 to alleviate pain in humans and companion animals. “The extreme and poorly treated pain that I observed as a medical officer working in a burn clinic in the Army, is a major driver for me to translate my research to help patients with severe pain.”
Phase 1 human clinical trials to test the drug candidate, EC5026, a first-in-class, small molecule that potently inhibitssEH, will begin Dec. 10 in Texas. The title: "A Single-Center, Double-Blind, Placebo-Controlled, Phase 1a Single Ascending Dose Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Sequential Dose Regiments of Oral EC5026 in Healthy Male and Female Subjects." Eight will participate; six with the drug candidate and two with the placebo. The technology was discovered in the Hammock lab and UC Davis has licensed patents exclusively to EicOsis.
“EC5026 is a key regulatory enzyme involved in the metabolism of membrane fatty acids,” Hammock said. "It's a novel, non-opioid and oral therapy for neuropathic and inflammatory pain. Inhibition of sEH treats pain by stabilizing natural analgesic and anti-inflammatory mediators."
The project is unique in that “there have been very few truly new types of analgesic compounds that have reached the market in the past 50 years,” Hammock said.
“The sEH enzyme is involved in regulating the activity of powerful anti-inflammatory fatty acids called EETs that are present in all cells in humans and animals,” the scientists explained in their awards application. “EETs are anti-inflammatory, analgesic, anti-hypertensive, but they are short lived molecules that are normally eliminated within seconds. By inhibiting sEH, EET levels can be increased by 4x or more and maintained at high anti-inflammatory and analgesic levels for 24 hours or longer.”
“The sEH inhibitors are very potent molecules that are designed for once daily oral dosing. They can also be administered intravenously for acute pain (e.g. equine laminitis),” they wrote. “Preclinical safety studies show that sEH inhibitors are very safe with no visible signs of toxicity at doses more than 100x higher than the therapeutic dose levels. Unlike conventional analgesics, they do not produce sedation or cognitive dysfunction and they have been shown to have no addiction liability, no adverse cardiovascular effects, and no adverse effects on the gastrointestinal tract. They can be safely co-administered with existing analgesic medications.”
Approximately 50 million Americans (20 percent of the population) suffer from chronic pain, according to the Center for Disease Control and Prevention. The annual economic toll is $560 billion, encompassing direct medical expenses, lost productivity, and disability claims. Pain research is now one of the top priorities of the National Institutes of Health (NIH).
EicOsis advancement of EC5026 into clinical trials has been funded as part of the Blueprint Neurotherapeutics Network (BPN) of the NIH Blueprint for Neuroscience Research. The BPN is a collaboration of NIH Institutes and Centers that supports innovative research on the nervous system with the goal of developing new neurotherapeutic drugs.
EicOsis (pronounced eye-cosis), derives its name from eicosanoid, “the major backbone of chemical mediators in the arachidonate cascade,” said McReynolds. “It symbolizes the epoxide group in chemistry, which is key to the anti-inflammatory chemical mediators and where the biochemical target called soluble epoxide hydrolase works.”
“Many variables are known to affect the actual spray coverage in crop fields,” said Nansen, an associate professor in the UC Davis Department of Entomology and Nematology said. “These include tractor speed, spray nozzles, spray volume, boom height, adjuvants, and weather conditions. But which ones are the most important ones? And are there possible interactions among some of these variables?”
Through Smart Spray, an app designed for both iOS and Android phones, growers can optimize and perform quality control of pesticide spray applications in their strawberry fields, Nansen said.
Computer science major Krishna Chennapragada, now an alumnus, launched the programming and initial design, tallying some 500 hours before his graduation. Today's team, in addition to Nansen, is comprised of recruits Gabriel Del Villar, a 2019 computer science graduate, and Alexander Recalde, a senior majoring in computer science. Together they have amassed nearly 400 hours on the project.
“The project is truly multidisciplinary,” said Nansen, adding “One of the great things about UC Davis is that the barriers between colleges are very, very shallow.”
The Smart Spray app, they said, allows a user to predict spray coverage under different operational scenarios, including type of nozzles, spray volume, and tractor speed, as well as weather data, such as temperature, relative humidity and wind. A key part of the process: the user places a water-sensitive card in the field prior to a spray application, photographs it, and uploads it into the app.
“If you're a grower, you might expect that when you go out to spray, that the more that comes out of nozzle, the better coverage you'll get,” Nansen said. “But, for example, if the wind is too strong, the relative humanity is too low, the pressure is too high, or you're going too fast--even when you're spraying large volumes--you can get very poor coverage and it's costly. Excessive spray can also reach other fields or nearby urban developments due to so-called “spray drift”.”
“Typically, a grower will spray 100 to 150 gallons per acre when he or she sprays,” Nansen explained. The water-sensitive card is yellow, but it codes blue when it interacts with moisture. “These cards have been around a long time,” he said. “They cost about $1 a card, not cheap. But it's inexpensive when you're spending thousands of dollars to control the pests. And the pesticide companies can pay for the cards.”
“Say you want to predict your coverage before you spray tonight or tomorrow,” Nansen explained. “Look at the weather conditions; what is the forecast? Then how are you going to do this? What if you spray 100 gallons and want to go two miles per hour. You enter the data—and all the other applicable data--on the Smart Spray app. It will predict the coverage you'll get with nine different nozzles. Those are the nozzles the typical strawberry grower uses, a number we based on almost 3000 experimental sprays over three years. So we did a lot of homework on this, for example—different spray rigs, different sizes of crops, different spacing of plants, and under different weather conditions. We covered all the ranges we could think of. We collected the water and operational data and we did the progression analysis (for the modeling).”
“Using this prediction, you can give it a name, say Field 6, and access it from the database,” Nansen said. “It's about quality control. It's a tool to predict and do quality control. It empowers the grower and also the sprayer to do a better job. For example, if the conditions are bad and the app shows the spraying will be only 20 percent effective, you shouldn't be spraying.”
“The Smart Spray is not just insecticides--it's fungicides, herbicides, and whatever you want to spray,” Nansen noted. “This app was developed for strawberries; if it were used for soybeans, onions and cabbage, it would still be useful but the accuracy would be off.” Pending apps: almond, pistachio and tomato.
The computer scientists enjoy working on the project. Recalde attended a Central Coast sprayers' meeting to talk about the app. “I heard ‘Oh, wow, you look so young!' he remembered. “Then we told them about this useful tool, different ways that technology can be applied to agriculture. They were really interested in how technology can improve what they're doing.”
Del Villar, whose computer interests also include teaching youth how to code, said he eagerly looks forward to making the Smart Spray app even better and more useful. Fluent in Spanish, as well as English, he plans to translate the app into Spanish. Other language translations are also in the works.
Now the team is seeking feedback to improve the app. “We're hoping growers will embrace it,” Nansen said, “and help us find ways to improve it.”
One feedback from Eric Flora, global field development and manager of Crop Enhancement, Inc., Paso Robles: “I think Smart Spray is a very helpful tool for growers and advisers as a guide to select spray tips, spray volumes, tractor speed, and other important factors to maximize sprayer coverage. Using spray cards is the best and simplest way to know, if you are penetrating everywhere in the canopy your pest target is a problem--placing cards where the specific pests attack the host gives the best information.”
State, federal and industry grants, including the California Strawberry Commission and the Floriculture and Nursery Research Initiative (FNRI) of the U.S. Department of Agriculture's Agricultural Research Service, help fund the project.
California grows about 88 percent of the nation's strawberries on approximately 34,000 acres along the California coast, according to the Strawberry Commission. Strawberries are available year-around in California.
Statewide, fresh strawberry production averages 50,000 pounds per acre each season. The approximately 300 strawberry growers hail from five distinct areas of California: Watsonville/Salinas, Santa Maria, Oxnard, Orange County/San Diego, and the Central Valley. They include multi-generation farming families growing both organic and conventional strawberries.
For more information on the Smart Spray app, access the manual at https://bit.ly/2q3lsL3 or contact Nansen at email@example.com or 530-752-2728.
Research Highlight Editor Lysa Maron spotlighted the work in her article, “Breaking or Sneaking into the Fortress: the Root Endodermis is a Defence Wall Against Nematode Infection.” The journal also showcased the research team's image of a nematode on the cover.
Siddique led the 10-member international research team in discovering the role of a plant's endodermal barrier system in defending against plant-parasitic nematodes. The Plant Journal published the research, “Root Endodermal Barrier System Contributes to Defence against Plant‐Parasitic Cyst and Root-Knot Nematodes, in its July 19 edition.
“We discovered that the integrity of the endodermis—a specialized cell layer that surrounds the vascular system and helps regulate the flow of water, ions and minerals--is important to restrict nematode infection,” said Siddique, an assistant professor in the UC Davis Department of Nematology who joined the faculty in March after serving several years at the University of Bonn.
“We found that having defects in endodermis make it easier for parasites to reach the vascular cylinder and establish their feeding site. Although, this finding is a result of basic research, it opens new avenues to for breeding resistance against cyst nematodes in crops.”
Maron noted that “Roots are a truly amazing plant structure: they conquer the underground, form complex structures that anchor the plant, let water and nutrients in, but must not dry out. Roots store energy, send signals to the aboveground parts of the plant and to neighbors, and defend the plant against soil-borne pathogens. Within the root, the endodermis is the barrier that separates the inner vasculature from the outer cortex. If the root is a fortress, the endodermis is the gated wall. Cell wall reinforcements such as the casparian strip (CS), lignin deposition, and suberin seal the apoplast of the endodermis throughout different parts of the root. These reinforcements allow the diffusion of water and nutrients to and from the vascular tissue while blocking its penetration by pathogens such as bacteria and fungi (Enstone et al., 2002).”
“But roots also face pathogens of a different kind: root-infecting, sedentary endoparasites such as cyst nematodes (CNs) and root-knot nematodes (RKNs),” Maron wrote. “These pathogens infect a variety of important crops and cause significant yield losses (Savary et al., 2019).”
Maron quoted Siddique: “According to Siddique, investigating root traits that affect plant-nematode interactions is important for finding new strategies for plant protection. Screening for natural variation in suberin- and lignin-related traits might help identify and develop stronger fortresses, i.e., plants with enhanced resilience against pathogens, drought, and nutrient deficiency.”
Siddique collaborated with scientists from Germany, Switzerland and Poland: Julia Holbein, Rochus Franke, Lukas Schreiber and Florian M. W. Grundler of the University of Bonn; Peter Marhavy, Satosha Fujita, and Niko Geldner of the University of Lasuanne, Switzerland; and Miroslawa Górecka and Miroslaw Sobeczak of the Warsaw University of Life Sciences, Poland.
“Plant-parasitic nematodes are among the most destructive plant pathogens, causing agricultural losses amounting to $80 billion annually in the United States,” said Siddique in an earlier news story. “They invade the roots of almond, tomato, beets, potato or soybeans and migrate through different tissues to reach the central part—the vascular cylinder--of the root where they induce permanent feeding sites.”
“These feeding sites are full of sugars and amino acids and provide the parasite all the nutrients they need,” Siddique explained. “A specialized cell layer called the endodermis surrounds the vascular system and helps regulates the flow of water, ions and minerals into and out of it. However, the role of endodermis in protecting the vascular system against invaders such as nematodes had remained unknown.”
The research was funded by a grant from the German Research Foundation.