Lesbian, gay, bisexual, and other sexual minority individuals—or LGB+—experience persistent health disparities and higher rates of depression related to discrimination and minority stress, yet the burden of chronic fatigue syndrome, a debilitating and often misdiagnosed condition, is not well understood amongst this population. A recent study used nationally representative U.S. survey data from 2021-2023 to estimate the prevalence of Chronic Fatigue Syndrome among LGB+ adults and examined whether LGB+ identity was associated with the condition. Study results showed that LGB+ adults had a higher prevalence of, and were nearly twice as likely to report, having Chronic Fatigue Syndrome compared to heterosexual adults even after adjusting for sociodemographic factors, comorbid conditions, and depression. These findings suggest that stressors prevalent in the LGB+ community (beyond depression) may contribute to elevated Chronic Fatigue Syndrome risk among LGB+ individuals. This highlights the need for equitable access to comprehensive medical and mental health care for this population. This study was conducted by Alexandra Balshi with Harvard Medical School, John Dempsey with the Norton College of Medicine, Hannah Thompson with the Nutrition Policy Institute, and Mary Montgomery with the Department of Infectious Diseases, Brigham and Women's Hospital.