NIH Research in Biomedicine and Agriculture Using Agriculturally Important Animals (SFS)
Date: September 27, 2018
Time: All Day
Contact: Vanity Campbell
Sponsor: Contracts and Grants
NIH Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (SFS)
Funding Opportunity Number: PAR-13-204
Funding Organization's Deadline: Wednesday, August 1, 2018 at 5:00 PM PST
Discipline/Subject Area: animal disease and welfare
ANR Priority Area(s): SFS
Funding Available($): ~1.5M; Not specified; less than 500,000 per year
Description: NIH NICHD and USDA NIFA requests applications for the Dual Purpose with Dual Benefit: Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species (R01).
The purpose of this funding opportunity announcement is to facilitate new and innovative comparative medicine research that expands our knowledge of basic and translational strategies to ameliorate human and agricultural animal disease and developmental and metabolic disorders and improve reproductive efficiency. The focal point of the FOA will be to stimulate and strengthen the application of large domestic animal species for addressing and elucidating specific complex biological mechanisms important to both biomedicine and agriculture.
Knowledge gained will provide “dual benefit” to both human and agricultural animal species and advance applications for the improvement of health, productivity and reproductive efficiency, encouraging investigations in the four areas identified as high priority issues to both biomedicine and agriculture through the use of pertinent domestic farm animal species that better mimic the specific human developmental, physiological or disease state.
Projects will broaden the fundamental understanding of normal animal and human physiology but also the etiology of metabolic and infectious diseases in four main topic areas to advance the development of biomedical and agricultural interventions or therapies to improve both human health and farm animal health and production, as follows:
- Reproduction, Stem cell biology and Regenerative medicine: Expand fundamental knowledge of processes that underlie human and animal reproduction by advancing our understanding of gametogenesis through the identification of molecular, physiological, and developmental mechanisms that regulate oogenesis and spermatogenesis; improve the efficiency of assisted reproductive technologies in human or cloning in farm animals; elucidate the molecular processes regulating reprogramming in early embryos, embryonic stem cells, induced pluripotent stem cells, and other lineage-specific stem cells, and in cloning (somatic cell nuclear transfer) to enhance tools and improve methods for cloning or the generation of transgenic animals; modify genetic traits of large animals using gene-editing technologies for selective breeding and generation of transgenic animals that mimic human diseases, or provide living, functional tissues to repair or replace tissue or organ functionality lost due to age, disease, damage or congenital defects in the human; characterize the core microbiome (including the metabolome of the microbiome) of the reproductive tract and study its impact on physiology and pathophysiology of reproduction.
- Metabolism: Establish the contribution of specific cell types, such as the adipocyte, and central or peripheral factors in the metabolism of lipids and their role in modulating fat accretion in tissues and/or during specific developmental stages; identify genetic and/or exogenous factors, such as diet or hormones, and determine their role in predisposition to or the onset of obesity; characterize the role of gastrointestinal microbiome (including the metabolome of the microbiome) on host metabolism in the context of adipose deposition and obesity. An understanding of the metabolism and regulation of fat accretion will identify ways in which to improve meat quality, thus its nutritive value to humans, and concomitantly provide insight for the development of novel therapies to reduce the current global epidemic of obesity.
- Developmental origin of adult disease: Investigate the role of placenta in health and disease of the mother and her fetus during pregnancy, postnatally in the offspring and during adulthood; Define in utero developmental programming events altered by maternal exposure to environment stressors (e.g. nutrition, drugs, temperature, pathogens, toxicants) or maternal health status (e.g. disease, obesity) that may be the origin of adult disease or may impair growth, fertility, meat quality, disease resistance, and other traits that are particularly important for agriculture; characterize the gestational and perinatal microbiomes (including the metabolomes of their microbiome) and study their relationship to growth, development, anti-microbial resistance, and to the origin of adult diseases. Quantifiable benefits to NIH and the USDA-NIFA will be the creation of innovative interventions that prevent or ameliorate disease and enhance desired traits to promote human and animal health, as well as economically important production traits for agriculture.
- Infectious diseases: Elucidate the genes and physiological mechanisms that regulate resistance and/or susceptibility to infectious pathogens of human or agricultural animals which will allow for the selection and generation of pathogen-resistant animals; develop interventions that decrease or prevent the transmission of pathogens from animal reservoirs to humans; identify environmental factors that contribute to the emergence of infectious pathogens to decrease or eradicate their occurrence; define organ or tissue-specific microbiome (including the metabolome of the microbiome) and its relationship to inflammation, immune response, infectious disease development, and antimicrobial resistance; develop genome editing strategies for treatment of infectious diseases. The prevention or eradication of infectious diseases substantially impacts human health and enables the generation of healthier, more superior farm animals.
The maximum project period is 5 years.
OCG Note: Please note any changes to the funding opportunity including deadline dates may not be updated to this calendar. Please visit the Sponsor's website below for additional information.