Sarah Silverman, a doctoral candidate who is studying insect demography at UC Davis with major professor James R. Carey, won a second-place award in her category.
Boudinot, who studies classification and evolution of morphology, delivered a 10-minute oral presentation in the Systematics, Evolution and Biodiversity Section on "The Protopodal Theory of Genitalic Evolution in the Hexapoda (Arthropoda: Mandibulata: Pancrustacea)."
Boudinot completed his undergraduate work at the Evergreen State College, Olympia, Wash., and spent a year working as a research technician at the University of Utah before starting his graduate work in 2014 with advisor Phil Ward. He focuses his research on evolution and ecology, approached from the perspective of systematics. “I integrate several lines of inquiry to answer historical evolutionary questions, including morphological and molecular phylogenetics, paleontology, and traditional comparative morphology,” Boudinot related. “I specialize on the skeletomusculature system of the male genitalia of the Hexapoda and the classification of the Formicoidea.”
Silverman gave a 10-minute oral presentation in the Diptera-Mosquitoes category of the Medical, Urban, and Veterinary Entomology Section, on “Population as Cohort: Interpreting the Mortality Patterns of Wild-Caught Adult Mosquitoes of Unknown Ages.”
Silverman completed her bachelor's degree in environmental science at McGill University in Montreal. For her undergraduate thesis, she studied the phenology of wild Osmia bees. Her work at UC Davis is in the field of insect demography. “I specifically study insect lifespan in the wild, as well as the the age-structure of insect populations in the wild using an innovative methodological approach: the capture of live-insects in the wild which are then maintained and observed in the lab until death,” she said.
At its annual meetings, the ESA offers graduate students the opportunity to present their research and win coveted prizes. The first-place President's Prize recipient receives a one-year free membership in ESA, a $75 cash prize, and a certificate. The second-place winner receives a one-year free membership in ESA and a certificate.
The oral presentations are evaluated on scientific content (50 percent) and presentation (50 percent). For scientific content, judges score them on introduction and background with pertinent literature cited; objectives clearly stated and concise; materials and methods (study design) clear and concise; results and discussion clear, concise and accurate; and significance of results to field of study. Judges evaluation the presentation on organization, slides and delivery.
Boudinot's previous President's Prizes were for work on the male genitalia of ants, and for providing the first male-based identification material for the ant genera of the New World.
Ants are highly diverse, with over 13,000 known species, Boudinot said. "They are, however, but one stitch in the diversity of all insects, and we are entering a new era for the study of morphology in the 21st century."
The genitalia of male insects are fascinating, he said. "Both male and female insect genitalia are derived from the appendages of a pair of abdominal segments. Evidence from the skeletomusculature indicates that these structures are really legs of a crustacean ancestor that have been modified for numerous reproductive tasks--from copulation and insemination, to singing and silk-spinning."
The event, free and open to the public and family friendly, is an annual open house focusing on parasitoids.
"An insect parasitoid is a species whose immatures live off of an insect host, often eating it from the inside out," said Tabatha Yang, education and outreach coordinator of the Bohart Museum. "It is part of their life cycle and the host generally dies."
Among the presentations or topics:
- Bohart Museum senior museum scientist Steve Heydon, a world authority on Pteromalids, or jewel wasps, a group of tiny parasitoids.
- Entomology PhD student Jessica Gillung who researches the Acroceridae family "a remarkable group of endoparasitoids of spiders."
- Diagnostic parasitologist Lauren Camp of the UC Davis Veterinary Medical Teaching Hospital, is an authority on nematodes.
- Family craft activity is a pop-up card, featuring a monarch chrysalis and a fly, suitable for mailing to friends and family during the holiday season.
There are some 3,450 described species of Pteromalids, found throughout the world and in virtually all habitats. Many are important as biological control agents.
Members of the Acroceridae are "rare and elusive flies lay the eggs on the ground or vegetation, and the little larva is in charge of finding itself a suitable host," Gillung said. "Upon finding the host, the larva enters its body and feeds inside until it's mature to come outside and pupate. They eat everything from the spider; nothing is wasted."
Lauren Camp, who received her doctorate from UC Davis, studying with major professor Steve Nadler, professor and chair of the UC Davis Department of Entomology and Nematology, will display a variety of nematodes amd answer questions.
She describes nematodes in one word as "worms" and in expanding, “Nematodes are an amazing phylum of organisms--they exist in almost every known environment on the planet, and different species eat everything from bacteria and fungi to plant and animal tissue."
Tachinid flies, which lay their eggs in caterpillars and chrysalids, will be on display, along with the remains of its hosts. It is used as a biological control agent for some pests. But those who rear monarch butterflies consider it their enemy when it lays eggs in their caterpillars and chrysalids.
The late UC Davis entomologist Richard M. Bohart (1913-2007) researched Strepsiptera, or twisted-wing parasites, for his doctorate in 1938. Both the Bohart Museum and an entire family of Strepsiptera, the Bohartillidae, are named in honor of Professor Bohart.
The Bohart Museum, directed by Lynn Kimsey, professor of entomology at UC Davis, houses a global collection of nearly eight million specimens. It is also the home of the seventh largest insect collection in North America, and the California Insect Survey, a storehouse of the insect biodiversity.
Special attractions include a “live” petting zoo, featuring Madagascar hissing cockroaches, walking sticks, praying mantids and tarantulas. Visitors are invited to hold some of the insects and photograph them. The museum's gift shop, open year around, includes T-shirts, sweatshirts, books, jewelry, posters, insect-collecting equipment and insect-themed candy.
The Bohart Museum holds special open houses throughout the academic year. Its regular hours are from 9 a.m. to noon and 1 to 5 p.m. Mondays through Thursdays. The museum is closed to the public on Fridays, Saturdays and Sundays and on major holidays. Admission is free.
More information on the Bohart Museum is available by contacting (530) 752-0493 or emailing firstname.lastname@example.org or Tabatha Yang at email@example.com.
Newly published research by an international team of scientists, headed by the Jun-Yan Liu lab of Tongji University, Shanghai, China, and the Bruce Hammock lab at the University of California, Davis, may provide promising therapeutic strategies for those suffering from acute kidney injury (AKI), formerly called acute renal failure.
AKI, common in hospitalized patients—especially among older adults in intensive care--occurs when the kidneys suddenly fail to filter waste products from the blood. Many of these patients do not recover or require dialysis or transplantation, or partly recover and are thus at risk for worsening kidney disease.
The paper, published in the current edition of the Proceedings of the National Academy of Sciences, found that a small molecule inhibitor of soluble epoxide hydrolase developed in the Hammock lab at UC Davis, helped alleviate AKI in mice and prolonged their lives.
“The soluble epoxide hydrolase or sEH degrades chemically stable fatty acid epoxides,” explained Hammock, a UC Davis distinguished professor who holds a joint appointment in the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. “But sometimes it can be useful to block the function of sEH, so that beneficial fatty acid epoxides, like those from omega-3 and omega-6 fatty acids, are not degraded. These fatty acid epoxides have been found to protect the kidney, reduce inflammation, inflammatory pain, and even chronic or neuropathic pain.”
In general, the epoxides of docosahexaenoic acid (DHA) from fish oil make the soluble epoxide hydrolase inhibitors even more effective, the Hammock lab has found. “However, in this case, the fish oil seemed to be deleterious rather than beneficial when combined with the sEH inhibitors with kidney injury,” Hammock said. This was unexpected and the investigators caution that fish oil may not always have beneficial effects.
Professor Jun-Yan Liu, a former postgraduate researcher and assistant project scientist in the Hammock lab, related that the lipid mediators that preserve the kidney in AKI are termed EETs. “Their levels can be changed by altering their degradation or biosynthesis with selective inhibitors. This increase in EET resulted in anticipated decreases in the plasma level of creatinine and urea nitrogen—both biomarkers for kidney injury.” He added that they are looking forward to the epoxide hydrolase inhibitors finishing phase I clinical trials in humans so they can be evaluated for preventing or treating AKI.
Specifically, the researchers discovered that a 14(15)-EET mitigated kidney injury and prolonged life, while another epoxide, 19(20)-EDP from fish oil, exacerbated the kidney injury and shortened life. “We found that epoxides of docosahexaenoic acid (DHA) and DHA-enriched fish oil worsened kidney injury prophylactically and therapeutically in multiple animal models of AKI,” wrote Liu, pointing out that fish oil has proven beneficial in a number of other investigations.
Statistics show that “the incidence of AKI in hospitalized patients increased dramatically from 4.9 percent in 1983 to 20 percent in 2012,” the researchers wrote in their paper. “The mortality from AKI is greater than 50 percent; worldwide, approximately 2 million people die of AKI every year. Therefore, novel, safe and effective approaches are urgently needed to prevent and treat AKI.”
“Because AKI has no specific effective therapy and treatment is merely supportive frequently requiring hemodialysis any new treatment or therapeutic paradigm would be welcome in the nephrology community and has the potential to improve the lives of many patients with AKI,” said kidney expert Dr. Robert Weiss, a professor of medicine in the UC Davis Division of Nephrology, who was not involved in the research.
Kidney injury expert Alan Parrish of the University of Missouri's School of Medicine, Columbia, also not involved in the research, called the findings “significant.”
“The collaborative studies between Dr. Liu's and Hammock's group are an elegant, and timely, contribution to our understanding of acute kidney injury (AKI),” said Parrish, vice chair for education and director of Graduate Studies for Medical Pharmacology at the medical school. “AKI has potentially devastating short-term consequences - high mortality - as well as the detrimental long-term impact on renal function. Importantly, specific interventions to treat AKI in patients have not yet been identified. These results are significant in that they provide a unique mechanistic insight into pathways targeted by soluble epoxide hydrolase inhibitors that attenuate AKI, providing a powerful rationale for future clinical trials in AKI patients.”
The paper is the work of scientists led by Jun-Yan Liu from the Center for the Nephrology and Metabolomics and Division of Nephrology and Rheumatology, Tongji University School of Medicine, Shanghai, China: Bing-Qing Deng, Ying Luo, Xin Kang, Chang-Bin Li, Jian Huang, Da-Yong Hu, Ming-Yu Wu, and Ai Peng; and Hammock and his lab researchers Jun Yang, Christophe Morrisseau, Kin Sing Stephen Lee at UC Davis.
CBP supports students engaged in pre-doctoral training at the chemistry-biology interface, preparing them for careers in the biomedical workforce. McReynolds is one of four students selected for the 2017-18 CBP training grant program.
“We are very proud of her,” said Hammock, distinguished professor of entomology, UC Davis Department of Entomology and Nematology, who holds a joint appointment with the UC Davis Comprehensive Cancer Center.
A member of the Pharmacology and Toxicology Graduate Group, McReynolds focuses her research on “developing chemical tools to elucidate the biological relevance of chemical compounds (dihydroxy diols) in biological systems.”
Hammock is her major professor. "Cindy has more than 12 years of experience in research and project management, extensive research experience and advanced knowledge of drug development,” Hammock said.
Prior to enrolling in the doctoral program, McReynolds served as the program administrator of UC Davis/National Institute of Environmental Health Sciences Superfund Research Program, directed by Hammock. She is the project manager of EicOsis, a Davis-based company founded by Hammock to develop a small molecule inhibitor to treat pain in humans and animals.
A native of Louisville, KY, McReynolds received her bachelor of science degree in animal science from UC Davis in 1999, and her master's degree in animal science in 2001 from Washington State University, Pullman, Wash., where she was named Outstanding Graduate Student, Teaching Assistant of the Year and recipient of the Dr. Ralph Erb Outstanding Graduate Student Award. Her master's thesis involved how dietary carotenoids inhibit tumor growth.
McReynolds then joined a project development team at Celera Corporation--an Alameda-based company involved in genetic sequencing and related technologies--that led to the selection of Vorinostat, a cancer treatment. She served as a team leader of the Tumor Development Team at Celera, tasked with developing new models of drug-resistant cancer and analyzing newly generated data from the Human Genome Project to identify new cancer therapies.
The seminar takes place from 4 to 5 p.m. in Room 3001 of the Plant and Environmental Science Building.
Audley is presenting a preview of his thesis project in the UC Davis Forest Biology Research Center Seminar Series.
The remaining schedule includes:
Nov. 1 – Alison Scott, postdoctoral student, UC Davis Department of Plant Sciences, “The Polyploid Origin and Evolutionary History of California Redwoods”
Nov. 15 – Brian Smithers, Ph.D student, Ecology Graduate Group, "Mechanisms of Range Shifts in Great Basin Sub‐Alpine Bristlecone Pine Forests."
Nov. 29 – Sarah Bisbing, assistant professor, Forest Ecosystem Science, Department of Natural Resources and Environmental Science, University of Nevada, Reno, "Looking Backward to See Forward: Causes and Consequences of Altered Disturbance and Climate on Western Conifer Forests.”
Dec. 6 ‐ Ryan Tompkins, Forest Silviculturist, U.S. Forest Service/Plumas National Forest, “Sierra Nevada Silviculture in the New World Order: Challenges, Uncertainties, and Opportunities”
All seminars will be held at 4 p.m. in Room 3001 of the Plant and Environmental Science Building. For more information, contact David Neale at firstname.lastname@example.org.