"Mr. GARAMENDI. Madam Speaker, I rise today to honor Bruce Hammock and his exemplary interdisciplinary career. He has been a legendary figure in his field for over four decades and his efforts have made critical advancements in our understanding of neurodegenerative diseases, non- addictive solutions to managing chronic pain, and environmental conservation.
"Dr. Hammock's recent research on regulatory enzyme inhibitors and their effect on neuroinflammation has reshaped the way we understand both the cause and cure of the degenerative disease. Alongside his UC Davis team, Dr. Hammock partnered with Baylor University as well as other researchers across the globe to study soluble epoxide hydrolase (sEH) and its effect on the brains of mice. Dr. Hammock's study found that inhibiting sEH may offer a new pathway to reduce neuroinflammation and neurodegeneration; leading to a breakthrough in recognizing the potential benefits of sEH inhibitors in Alzheimer's treatment.
"Groundbreaking research is nothing new in the world of Dr. Hammock. He is currently a distinguished professor at UC Davis in the Department of Entomology and Nematology and part of the UC Davis Comprehensive Cancer Center. During his time at the university Hammock has been at the helm of the Superfund Research Program for over three decades--a government-funded program focused on finding solutions to the complex health and environmental issues linked with the nation's hazardous waste sites.
"In addition to his invaluable contributions to science, Dr. Hammock has taken up another admirable charge--to make science and learning fun. Every year he and his lab organize a water balloon fight between faculty and students on the lawn of UC Davis' Briggs Hall where other labs and bystanders join in on the action. This event is a small glimpse into Hammock's unique character--one described by colleagues as enthusiastic, creative, and hard-working. Dr. Hammock's limitless drive and curiosity contribute both to the stellar reputation of UC Davis as an esteemed research institute and California's 3rd Congressional District as a whole. We wish him all the best in his endeavors and look forward to seeing all that he accomplishes in the future."
Hammock, who holds a joint appointment with the UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center, joined the UC Davis faculty in 1980. He is the founding director (1987-present) of the UC Davis NIEHS (National Institute of Environmental Health Sciences) Superfund Research Program and is a founding member (1990-present) of the UC Davis Comprehensive Cancer Center.
Hammock co-discovered a human enzyme termed Soluble Epoxide Hydrolase (sEH), a key regulatory enzyme involved in the metabolism of fatty acids. It regulates a new class of natural chemical mediators, which in turn regulates inflammation, blood pressure and pain. Hammock and his lab have been involved in enzyme research for more than 50 years.
Hammock is the founder and chief executive officer of the Davis-based pharmaceutical company, EicOsis LLC, formed in 2011 to develop an orally active non-addictive drug for inflammatory and neuropathic pain for humans, as well as a version in development for treating painful conditions in companion animals. A drug candidate known as EC5026 and now in human trials, targets a novel pathway to block the underlying cause of certain types of pain
Highly honored by his peers, Hammock is a fellow of the National Academy of Inventors, which honors academic invention and encourages translations of inventions to benefit society. He is a member of the U.S. National Academy of Sciences, a fellow of the Entomological Society of America, and the recipient of the Bernard B. Brodie Award in Drug Metabolism, sponsored by the America Society for Pharmacology and Experimental Therapeutics. He is the first McGiff Memorial Awardee in Lipid Biochemistry. The Eicosanoid Research Foundation recently honored him for work on oxidized lipids.
Hammock and his laboratory are now deeply involved in COVID-19 research. The National Institute of Environmental Health Sciences today posted their work: "Biomarker Suggests Severity of COVD-19 Respiratory Distress."
"In a study funded in part by NIEHS, researchers reported April 1 that certain fatty acids in the blood of COVID-19 patients may predict the severity of adult respiratory distress syndrome (ARDS)," the article began. "The fatty acids may also offer a target for treatment. ARDS, characterized by fluid buildup in the lungs, is the second leading cause of death in COVID-19 patients, according to the National Center for Biotechnology Information.
"Bruce Hammock, Ph.D., longtime NIEHS grantee and director of the NIEHS-funded University of California, Davis (UC Davis) Superfund Research Program (SRP) Center, led the study. His team examined six COVID-19 patients over five days and found that those with severe lung involvement showed higher levels of certain fatty acids compared with healthy control subjects. These fatty acids, called leukotoxins and leukotoxin diols, are known to play a role in inflammatory disease and ARDS, but this is the first study of their role in respiratory complications related to COVID-19."
Water Balloon Battles
Insisting that science should be fun, Hammock launched the Bruce Hammock Lab Water Balloon Battles nearly 20 years ago on the Briggs Hall lawn (outside his office) as a way to develop camaraderie in his lab; to take a 15-minute break; and to beat the triple-digit heat. The battle, usually waged on a sweltering July afternoon, is basically "15 Minutes of Aim" because that's how long it takes for the 30-some water warriors to toss 2000 water balloons at one another. Stray buckets of water are fair game, too.
Water balloon battle coordinator Christopher Morisseau, who holds the title of "professional researcher" in the Hammock lab, says the annual event is open to "all who want to get wet," which includes students and faculty of other UC Davis labs, spouses, children, and passersby. One year a police officer joined in.
The COVID-19 pandemic canceled the 2020 water battle. And COVID, coupled with the renovation of Briggs Hall and the grounds, may cancel this year's clash as well. (See images of the 16th annual event, a super-soaker that took place July 12, 2019.)
The tribute to Bruce Hammock in the Congressional Record is well deserved. And it's also good to see the Bruce Hammock Lab Water Balloon Battle mentioned. How many times have you seen a UC Davis water balloon battle entered in the Congressional Record?
"World Robber Day?" you ask.
No, "World Robber Fly Day."
Among those celebrating this special day is doctoral candidate Charlotte Herbert Alberts of the Department of Entomology and Nematology, University of California, Davis, where she studies robber flies (Diptera: Asilidae) with distinguished professor Lynn Kimsey, director of the Bohart Museum of Entomology.
World Robber Day takes place every April 30. What's different this year? Well, the COVID-19 pandemic, for one. And she and husband George now have a darling baby boy, Griffin, born in April 2020.
Contrary to popular opinion, Griffin's first word was not "Asilidae." (It was "Hello.") And yes, his crib contains a robber fly, a gift crocheted by Rebecca Godwin of the Jason Bond lab. She is now an assistant professor of biology at Piedmont University, Demorest, Ga.
"I think the robber fly looks like a Holococephala sp.," Charlotte says.
Globally, there are more than 7500 described species of robber flies. Most people have neither seen nor heard of the insects. "This anonymity is probably due to a variety of reasons," she says. "Many people call them assassin flies because of their tendency to look like other insects, in particular, wasps or bumble bees." They are also territorial, with one or two individuals in a given area. "It can take a while to find your first robber fly, but once you do, you will start to see them all over the place!"
Where can you find them? "Go into the woods and look for sunny spots with areas for the flies to perch on," Charlotte says. "They mostly perch on the flat surface of a leaf in the sun, or at the very tip of a pointy twig. From their perch, they can hunt for insect prey in flight. Once they spot prey, the assassin fly quickly intercepts it in flight and immediately pierces it with its hypodermic needle-like mouthparts to inject a paralytic neurotoxin to subdue it. Pre-digestive enzymes are also inserted to reduce the innards into a smoothie-like concoction, which the assassin fly feeds on through the needle-like hypopharynx."
"Despite being venomous and highly voracious predators, assassin flies are no danger to us! I caught my first assassin fly in the palm of my hand! Because they are top predators in their world, they are not very fearful of people. I routinely have had them perch on me to hunt prey. But be careful, some of the larger assassin flies can pierce the skin with a defensive bite if they are aggravated enough. Their bites have been compared to a honey bee sting."
Charlotte points out that "All insects play essential ecosystem roles that directly or indirectly affect our daily lives, whether through pollination, population control of pests, decomposition, product production, and more. Insects, and especially flies, face a stigma that is difficult to overcome. Assassin flies are a fantastic, charismatic example of a family of flies that are generally unknown by the public and yet is one of the most speciose and helpful in pest population control. I have regularly played with the idea of keeping a couple as house pets to control the other unwanted flying insects that make it into our house."
Charlotte, whose major roles currently include entomologist, artist, wife and mother, developed her love of entomology on the family farm in New Hampshire. She remembers her mother reading "Charlotte's Web" to her and being delighted that "a spider shared my name." The farm yielded scores of insects and spiders that fascinated her. "I couldn't understand why people hated spiders and insects so much. When handled gently and with love, they never bit or hurt me so I saw no reason to be scared of them...they were just misunderstood."
Little Griffin is following in her footsteps. Next year he'll probably say "Happy Robber Fly Day."
Or maybe "Happy Asilidae Day."
If so, then when the 107th annual UC Davis Picnic Day, themed "Discovering Silver Linings," takes place virtually on Saturday, April 17, better wear your sunglasses with all that silver blasting at you.
A silver lining is a sign of hope in a negative situation, like the COVID-19 pandemic. So positivity blocks such negativity as "every rose has its thorn" or "there's a fly in every ointment" or "all that glitters is not gold."
All that glitters is silver now.
On April 17, you can discover scores of silver linings at this "all virtual" family-oriented event, which promises to be informative, educational and entertaining.
Picnic Day officials have released the schedule of events and they include entomological exhibits and talks. Think UC Davis Department of Entomology and Nematology, Bohart Museum of Entomology and the UC Davis Graduate Student Association. (See yesterday's Bug Squad blog)
Don't miss the pre-recorded talk on the Gulf Fritillary butterfly, Agraulis vanillae, by Greg Kareofelas, Bohart Museum associate and naturalist. These orange-reddish butterflies, with their silver-spangled underwings, are glorious. (See what UC Davis butterfly guru Art Shapiro, distinguished professor of evolution and ecology, says about them on his website.) Kareofelas will showcase them and show you how to rear them, which is what he did last year during the pandemic.
Entomologist Jeff Smith, the volunteer curator of the Lepidoptera collection at the Bohart, will present a live Zoom event from 1 to 2 p.m. on Saturday on mimicry in Lepidoptera (moths and butterflies). "I will briefly mention camouflage," Smith says, "and spend most of the time on mimicry for defense--mimics of toxic or distasteful species, mimicry using odors or sounds, mimics of snakes or spiders, and mimics of non-food materials such as bird feces."
To connect, access https://ucdavis.zoom.us/j/92841203978?pwd=ay91SUpFZnl5MEdnVmlzOUxmMFFZQT09
Zoom Meeting ID: 928 4120 3978
Zoom Passcode: 160485
"People who want to submit their questions to Jeff or request to see certain species from the collection can email their requests to email@example.com with Picnic Day in the subject," says Tabatha Yang, the Bohart Museum's education and outreach coordinator. "We won't have the time or capacity to access the collection during the event for any requests. Instead, we will pull the items that are requested or relevant to the talk and have those prepared to show. Of course we may not be able to honor everyone's request, but we will do our best."
The Bohart Museum, located in Room 1124 of the Academic Surge Building on Crocker Lane (the museum is closed now due to the pandemic), is directed by Lynn Kimsey, UC Davis professor of entomology. It houses nearly eight million insect specimens, plus a year-around gift shop and a live "petting zoo," comprised of Madagascar hissing cockroaches, stick insects and tarantulas.
The popular cockroach races, hosted by the UC Davis Entomology Graduate Student Association (EGSA), will take place during the 107th annual UC Davis Picnic Day on Saturday, April 17, but you'll see them only on your computer screen--not in person.
That's because the 2021 Picnic Day is going virtual due to the COVID-19 pandemic precautions.
EGSA Picnic Day coordinator Erin "Taylor" Kelly, a graduate student in the laboratory of medical entomologist-geneticist Geoffrey Attardo lab, UC Davis Department of Entomology and Nematology, says the American cockroaches are housed in the basement of Briggs Hall and ready to go.
No personal trainers for them. "They will be pushed down the track by small pumps of air," she says.
Enthusiasts can cheer for their favorite racers and order stickers and roach race t-shirts from the EGSA website, which helps fund EGSA activities.
Where can you access the EGSA events on Saturday? On the UC Davis Picnic Day website at https://picnicday.ucdavis.edu
Here are the EGSA's 14 stations on tap. The links will all appear on the UC Davis Picnic Day website on or before April 17.
This is a live Zoom session from 12 noon to 3 p.m., with questions and answers. Folks can ask questions about insects and spiders.
EGSA T-Shirt Sales
Livestream on Zoom, 11 a.m. to 12 noon
Viewers can join a Zoom room and watch the American cockroaches race to victory.
Live Zoom session with questions and answers, from 10 to 11 a.m. with Cooperative Extension specialist Ian Grettenberger, assistant professor, UC Davis Department of Entomology and Nematology. A downloadable worksheet will be available.
Apre-recorded video by Professor Richard Karban, UC Davis Department of Entomology and Nematology, an expert on plant communication. The video is at https://youtu.be/xOXSqy05EO0
A pre-recorded video on "The Wonderful World of Nematodes" by nematologist Steve Nadler, professor and chair, UC Davis Department of Entomology and Nematology
Apre-recorded video by ant lab of Professor Phil Ward, UC Davis Department of Entomology and Nematology. Graduate students in the Ward lab will talk about their ant research. A downloadable coloring sheet will be available.
This will include links to all of the department-based KQED videos and a downloadable cooring sheet.
Professor Sharon Lawler, UC Davis Department of Entomology and Nematology, will offer a pre-recorded video, adapted from her live lil' swimmers exhibit. She will display water striders, dragonflies and damselflies and discuss their biology.
A downloadable PDF from the lab of Professor Neal Williams, pollination ecologist, UC Davis Department of Entomology and Nematology. This involves whether bumble bees can take the heat: "Will the increase in extreme heat in California affect these cool-weather loving pollinators and their ability to persist?" This UC Davis research group is trying to figure this out. Folks can help them conduct this work by submitting observations of bumble bee nests in the Davis/Sacramento area so that monitoring efforts can begin gathering critical data.
A pre-recorded video. Learn about the Davis Fly Fishers Club.
A downloadable worksheet will be offered.
This will be pre-recorded/reposted video from the Sacramento-Yolo Mosquito Control District. Folks can learn about local vector control.
"For my presentation on mimicry within Lepidoptera, it will briefly mention camouflage and spend most of the time on mimicry for defense--mimics of toxic or distasteful species, mimicry using odors or sounds, mimics of snakes or spiders, and mimics of non-food materials such as bird feces," Smith said.
The Bohart Museum, temporarily closed, is directed by Lynn Kimsey, professor of entomology.
An online global symposium celebrating “The Life and Legacy of Wittko Francke,” a renowned organic chemist based at the University of Hamburg, Germany--and a frequent collaborator with several UC Davis scientists--brought out his humanity.
Professor Francke died Dec. 27, 2020 at age 80 of complications from COVID-19.
The 29 speakers praised him as a brilliant and pioneering scientist, a dedicated teacher and researcher, a kind and loyal friend, a connoisseur of good wine and good food, and a generous—and sometimes anonymous—humanitarian. They also lauded his mentoring, congeniality, sense of humor, “keen olfactory system” and his Ping Pong skills.
“Wittko was one of the great pioneers shaping chemical ecology and the International Society of Chemical Ecology (ISCE),” said Leal, a member of the UC Davis Department of Molecular and Cellular Biology faculty and a former chair of the UC Davis Department of Entomology. Francke served as ISCE president in 1989-90, and Leal in 2000-01.
Panelist and former ISCE president John Hildebrand of the University of Arizona said: “Every encounter with Wittko was unforgettable.”
Former student Jan Bergmann of the Pontifica Universidad Católica de Valparaíso, Chile, a past president of the Latin American Association of Chemical Ecology, said the scientific community lost “a very productive and passionate researcher, a great colleague, mentor and friend.”
Toward the end of the symposium, Wittko's two sons, Christian and Michael offered their remembrances. Christian disclosed that Daaks-Chemicals, a key sponsor at an ISCE annual meeting, was “a fake” business meant to disguise the real donor--his father.
Leal then announced a fundraising project for the International Society of Chemical Ecology: “The Wittko Francke's Daaks-Chemical Fund."
Leal related this week that "There was enormous support. ISCE has now received more than $23,000. In honor of Wittko, ISCE will be establishing the annual Wittko Francke's Daaks-Chemicals Memorial Lecture."
It was Seybold who introduced Francke when he was a guest speaker at a UC Davis Department of Entomology and Nematology seminar on Dec. 8, 2010. Images of them, along with Leal, postdoctoral scholar Zain Syed, and doctoral student Leslie Saul-Gershenz, opened the April 3rd symposium.
Among the speakers was UC Berkeley professor Dave Wood, now 90, who was Seybold's major professor.
The event concluded with chemical ecology icon Wendell Roelofs, emeritus professor of Cornell University, and his wife, Joanne, offering a toast to the late chemical ecology giant who cherished good science, good friends and good wine.
The symposium drew widespread praise.
“I received more than 40 emails from people I know very well and others I never had the pleasure to meet; they shared their thoughts about the celebration,” Leal related. “Perhaps, one comment captures the sentiment of all: ‘Contributions to chemical ecology like Wittko's are at the center of why our field is so rewarding.'”
One email was from a professor from Japan, Shigeru Matsuyama, who collaborated with Seybold. “He wrote me that he was surprised that Steve Seybold had passed,” Leal said. “He had visited Seybold and his family in Davis and mentioned he “had a wonderful time, seeing his laboratory, walking around Davis Farmers Market, and enjoying food at Guadalajara.”
Born Nov. 28, 1940 and raised in Reinbek, near Hamburg, Germany, Francke studied chemistry at the University of Hamburg, obtaining his doctorate there in 1973. His thesis: "The Aggregation Pheromone of the Bark Beetle, Xyloterus domesticus. He was appointed professor of the Institute of Organic Chemistry of the University of Hamburg in 1985 and had served there until after his retirement.
A colleague once called him "The Mozart of Molecules," which Jan Bergmann noted, "summarizes eloquently the admiration of many had for his work, which is documented in more than 450 scientific publications." Among Francke's many global honors: the 1995 ISCE Silver Medal.
Former Francke student Stefan Schulz, a professor at the Institute of Organic Chemistry, Germany, an ISCE past president, wrote on the symposium's registration page: "Even in his early years, he showed some characteristics many associates with him, such as energy, determination, imagination, and creativity. Despite several offers, he stayed his whole academic career at the University of Hamburg, where he finally became a Full Professor and served different functions, including Dean of Chemistry. He always liked to teach, which he did happily even in his later years."
Max Planck Institute for Chemical Ecology tweeted Dec. 29, 2020: "Wittko Francke's death is a severe loss for the field of Chemical Ecology. He was not only a great chemist, but he also had a large influence on the development of our institute being a key member of the advisory committee that set up our institute."
France was not only an "outstanding, hard-working scientist" but a "loving husband, father of two children and grandfather of four grandchildren," Bergmann wrote. "He was also a person with incredible kindness and generosity....He enjoyed bringing people together and deeply cared about his students, many of which stayed in touch with him long after they left his research group. His legacy will live on in those of us he has inspired and guided in so many ways."