What's a fair without insects?

Entomologists at the University of California, Davis, will share their love of insects with fairgoers at the 144th annual Dixon May Fair, which opened today (Thursday, May 9) and continues through Sunday, May 12.

Have a question about insects?

Entomologist Jeff Smith, who curates the Lepitopdera (butterfly and moth) section at the Bohart Museum of Entomology, UC Davis, and Alex Dedmon, a forensic entomologist and doctoral student at UC Davis, will be showing bee, butterfly, dragonfly and other specimens, and live insects from the "petting zoo," including walking sticks and Madagascar hissing cockroaches.   Fairgoers are encouraged to hold them, photograph them and ask questions.

Smith and Dedmon will be at the fair on Saturday, May 11 from 11 a.m. to 3 p.m. in the Floriculture Building. Smith was honored in 2015 as a "Friend of the College," a coveted award presented by the College of Agricultural and Environmental Sciences.  He saved the museum some $160,000 over a 27-year period through his volunteer service (See news story.)

Dedmon studies with forensic entomologist Robert Kimsey, an adjunct professor in the UC Davis Department of Entomology and Neamtology.

The Bohart Museum, directed by Lynn Kimsey, professor of entomology, is the home of nearly eight million insect specimens, plus a year-around gift shop and a petting zoo.  The gift shop is stocked with books, jewelry, t-shirts, insect-collecting equipment, insect-themed candy, and stuffed animals.

The Bohart Museum, founded in 1946 by UC Davis entomologist Richard “Doc” Bohart (1913-2007), is open to the general public Mondays through Thursdays, from 9 a.m. to noon and from 1 to 5 p.m., plus occasional, weekend open houses​. Admission is free. The next weekend event will be "Moth Night" on Saturday, Aug. 3 from 8 p.m. to 11 p.m. Further information is available on the Bohart Museum website or contact (530) 753-0493 or bmuseum@ucdavis.edu.

You don't have to travel the world to see insects.

You can see them at the Bohart Museum of Entomology during the campuswide UC Davis Picnic Day, set Saturday, April 13. The theme is "Will Travel for Bugs: The Bohart Museum of Entomology's Collections From Around the World."

The Bohart Museum, located in Room 1124 of the Academic Surge Building on Crocker Lane, will be open from 11 a.m. to 2 p.m., a change from last year's hours. The shorter hours will allow the Bohart Museum folks to help with the UC Davis Department of Entomology and Nematology's displays at Briggs Hall and the “Black Widow-on-Parade” entry in the UC Davis Picnic Day Parade.

"At the Bohart, we are focusing on the various countries from around the world and some of their insect fauna," said Tabatha Yang, education and outreach coordinator. The 12 countries that the Bohart is highlighting are:

• Australia
• Belize
• Democratic Republic of Congo
• Korea
• Madagascar
• Malayasia
• Mexico
• Papua New Guinea
• Peru
• Republic of South Africa
• Turkey
• United States

“So for anyone who is from there, has lived there, has visited there, or who wants to visit there, please come and take a peak at some unique insects from around the world,” Yang said. “Some people enjoy traveling to explore cuisine and culture, but traveling for the flora and fauna of the world is equally wonderful. Insects are an important part of nature, so be curious, not afraid.”

There's also something special about this year's display at the Bohart. Its exhibit, "Will Travel for Bugs: The Bohart Museum of Entomology's Collections From Around the World," has been nominated for the Planet Earth Award. "Visitors will have the opportunity to vote for their favorite exhibits in five award categories," according to Madhuri Narayan, UC Davis Picnic Day exhibits director.  A QR code, linked to the voting survey, will be displayed at the museum. Or folks can vote here from 8 a.m. to 10 p.m. April 13. The prize for earning the most votes? "An awesome certificate and bragging rights," Narayan said.

Briggs Hall. At Briggs Hall, home of the UC Davis Department of Entomology and Nematology, the honey tasting booth has also been nominated for a special award. The Honey tasting is being organized by Extension apiculturistElina Lastro Niño. Briggs Hall will also offer maggot art, cockroach races, a bee observation hive and displays featuring aquatic insects, forensic entomology, and ants, among others, according to co-chairs forensic entomologist Robert Kimsey and doctoral student Brendon Boudinot. The Bug Doctor, the UC Statewide Integrated Pest Management Program,  the Sacramento-Yolo Mosquito and Vector Control District, and the Davis Fly Fishers will staff booths. Also planned: insect face painting, t-shirt sales and a bake sale. Both the UC Davis Entomology Graduate Student Association, headed by president Boudinot, and the UC Davis Entomology Club,  advised by Kimsey, will participate in the day's events.

Campuswide Picnic Day. The 105th annual UC Davis Picnic Day is free (free parking, free admission). It serves as the university's annual open house for prospective and current students, families, alumni, staff, faculty, and the greater Davis and regional communities. Picnic Day begins with the parade opening ceremony at 9:30 a.m., and the parade begins at 10 a.m. Most events will run from 10 a.m. to 4 or 4 p.m.  (See website.)

Popular traditional events:

• The Battle of the Marching Bands
• Doxie Derby Race
• Chemistry Magic Show
• Children's Discovery Fair
• Fashion Show
• Parade
• Cockroach Races
• Student Organization Fair
• Entertainment Stages

Bohart Museum. The Bohart Museum, directed by Lynn Kimsey, professor of entomology at UC Davis. was founded in 1946 by UC Davis entomologist Richard “Doc” Bohart (1913-2007). It is the home of nearly eight million insect specimens, plus a year-around gift shop and a live "petting zoo" that includes Madagascar hissing cockroaches, stick insects, tarantulas and praying mantids. The gift shop is stocked with books, jewlery, t-shirts, insect-collecting equipment, insect-themed candy, and stuffed animals.

The Bohart Museum is open to the general public Mondays through Thursdays, from 9 a.m. to noon and from 1 to 5 p.m.,   plus occasional, weekend open houses​. Admission is free. Further information is available on the Bohart Museum website.

Butterflies, beer and a bar...Who wants to drink to science?

If you've ever wanted to converse with butterfly guru Art Shapiro, UC Davis distinguished professor of evolution and ecology, about "butterflies and the  apocalypse" and sip a beer (or another beverage) at the bar at the same time, here's your chance.

The Davis Science Café has booked "A Conversation with Arthur Shapiro: Butterflies as Heralds of the Apocalypse" at 5:30 p.m., Wednesday, April 10 in the G Street Wunderbar, located at 228 G St., Davis. The event, hosted by professor Jared Shaw, professor and interim department chair of the UC Davis Department of Chemistry, is free and open to the public (but the refreshments  are not).

Shapiro has monitored butterfly population trends on a transect across central California since 1972. The 10 sites stretch from the Sacramento River Delta through the Sacramento Valley and Sierra Nevada mountains to the high desert of the Western Great Basin. The largest and oldest database in North America, it was recently cited by British conservation biologist Chris Thomas in a worldwide study of insect biomass.

A favorite of the news media, Shapiro has recently been featured in Newsweek, Washington Post, New York Times and the Los Angeles Times. Bay Nature magazine writer Eric Simons recently interviewed him for his piece on "What Do You Do About the Insect Apocalypse?"

What's going on with the butterflies?

The overwintering western population of the monarch butterfly on the central California coast declined 86 percent last winter,  the Xerces Society for Invertebrate Conservation indicates on its website. "Working at a conservation nonprofit means that we often come across bad news, but the results from this winter's Western Monarch Thanksgiving Count left us shocked: an all-time record low of 28,429 monarchs at 213 sites. This number is an 86% drop from the previous count done at Thanksgiving 2017, when 192,668 monarchs were counted at 263 sites (comparing only the sites monitored in both years)—and a dizzying 99.4% decline from the numbers present in the 1980s (Schultz et al. 2017). In short, only one of every 160 monarchs present in the 1980s exists today."

At the 2018 Butterfly Summit at Annie's Annuals and Perennials in Richmond, Shapiro told the crowd that "The vast majority of the butterflies we monitor are emerging earlier in the year now than they were in the 1970s."

His research shows that not only are butterflies coming out earlier, but "we also find trends in population and species richness."

Shapiro, a member of the UC Davis faculty since 1971 and author of the book, Field Guide to Butterflies of the San Francisco Bay Area and Sacramento Valley Regions, said that "in a nutshell, at low elevations, butterfly faunas have been declining slowly until 1999. In 1999, 17 species had an abrupt fall in abundance, spontaneously. On its face, this was a non-random event. The decline was then rapid from 1999 to the onset of the recent drought and then things went up again."

Science Café, initially supported by the National Science Foundation, is currently supported by the Department of Chemistry and Division of Mathematical and Physical Sciences and promoted by Capital Science Communicators.

Science Café sessions are hosted the second Wednesday of each month.  Topics so far this year? Plant ecologist Mark Schwartz of the UC Davis Department Environmental Sciences and Policy held forth at the March session on "Does California Have a Wildfire Problem? Can It Be Fixed?"  The February session featured Professor Roland Faller of the UC Davis Department of Chemical Engineering on "Using Computers to Understand Materials: From Proteins to Semiconductors" while Professor Denis Marcellin-Little of the UC Davis School of Veterinary Medicine's Surgical and Radiological Sciences discussed "Don't Try That at Home; High-End 3D Printing in Orthopedic Surgery" at the January session.

So it's butterflies and the apocalypse on April 10. Ask your questions, sip an adult beverage (or another beverage) and enjoy the evening!

 Bruce Hammock, distinguished professor at the University of California, Davis, who holds a joint appointment with the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center, is fond of saying that "Science is full of surprises."

A member of the UC Davis faculty since 1980, Hammock received his doctorate in entomology and toxicology from UC Berkeley, where he studied insect science. He now devotes his research to human health.

What many people do not know, however, is that he began his career studying how caterpillars turn into butterflies.

That morphed into human health research.

“The work led to the discovery that many regulatory molecules are controlled as much by degradation and biosynthesis,” Hammock related. “The epoxy fatty acids control blood pressure, fibrosis, immunity, tissue growth, pain and inflammation to name a few processes.”

 Fast forward to today.

An enzyme inhibitor developed in the Hammock lab and tested in mice by a team of international researchers shows promise that it could lead to a drug to prevent or reduce the disabilities associated with the neurodevelopmental disorders of autism and schizophrenia.

What the Inhibitor Did
"We discovered that soluble epoxide hydrolase (sEH) plays a key role in inflammation associated with neurodevelopmental disorders. Inhibiting that enzyme stops the inflammation and the development of autism-like and schizophrenia-like symptoms in animal models,” said collaborator Kenji Hashimoto, a professor with the Chiba University Center for Forensic Mental Health, Japan. The scientists found higher levels of sEH in a key region of the brain—the prefrontal cortex of juvenile offspring-- after maternal immune activation (MIA).

“Mothers who have MIA, which results from severe stress in that region of the brain, have an increased occurrence of neurodevelopment disorders in their offspring,” Hashimoto explained. “In our study, the sEH enzyme increased dramatically in a key brain region of mice pups from mothers with MIA.”

The news embargo lifted today (March 18) on their research, to appear in the Proceedings of the National Academy of  Sciences (PNAS). (Link will be here: https://www.pnas.org/cgi/doi/10.1073/pnas.1819234116.) It's the work of 14 researchers from Chiba University Center for Forensic Mental Health; the Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, in Wako, Saitama, Japan; and the Hammock laboratory.

Reversed Cognitive and Sciatl Interaction Deficiencies
By inhibiting sEH, the researchers reversed cognitive and social interaction deficiencies in the mice pups. They hypothesize that this is due to increasing natural chemicals, which prevent brain inflammation. In people, this could reduce the disabilities associated with autism, such as anxiety, gastrointestinal disturbances and epilepsy.

Earlier studies have indicated a genetic disposition to the disorders. The team also studied postmortem brain samples from autism patients that confirmed the alterations.

“In the case of both autism and schizophrenia, the epidemiology suggests that both genetics and environment are contributing factors,” said neuroscientist and associate professor Amy Ramsey of the Department of Pharmacology and Toxicology, University of Toronto, who was not involved in the study. “In both cases, maternal infection is a risk factor that might tip the scales for a fetus with a genetic vulnerability. This study is important because it shows that their drug can effectively prevent some of the negative outcomes that occur with prenatal infections. While there are many studies that must be done to ensure its safe use in pregnant women, it could mitigate the neurological impacts of infection during pregnancy.”

May Lead to Important Therapeutic Intervention
Neuroscientist Lawrence David, professor and chair of the School of Public Health, University of Albany, N.Y., who was not involved in the research, said that the study might lead to “an important therapeutic intervention for neurodevelopment disorders.”

“There is increasing evidence that maternal immune activation activities (MIA) during fetal development can lead to aberrant neurobehaviors, including autistic-like activities,” said Lawrence, who studies neuroimmunology and immunotoxicology. The study “suggests that enzymatic control of fatty acid metabolism is implicated in neuroinflammation associated with schizophrenia and autism spectrum disorders. The expression of Ephx2 giving rise to soluble epoxide hydrolase (sEH) influences production of fatty acid metabolites, which elevate inflammation in the experimental model of mice after MIA; the sEH inhibitor TPPU (N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl)-urea) was postnatally used to improved behaviors. Analysis of cadaver brains from individuals with ASD also expressed increased sEH. Fatty acid metabolites have been known to affect fetal development, especially that of the brain; therefore, TPPU might be an important therapeutic intervention for neurodevelopmental disorders.”

Molecular bioscientist Isaac Pessah of the UC Davis School of Veterinary Medicine, distinguished professor and associate dean of research and graduate education in the Department of Molecular Biosciences, described the findings as “significant” and called for more detailed and expanded studies.

“There is mounting evidence that inappropriate maternal immune responses during pregnancy to infection contributes elevated risk to autism spectrum disorder, at least in a fraction of cases,” Pessah said. “The most significant findings reported here is that a commonly used mouse model of immune-triggered behavioral deficits mimicking some of the core symptoms in autistic children can be suppressed by inhibiting a novel biochemical target, soluble epoxide hydrolase; a target not previously explored as a target for therapeutic intervention to treat ASDs. These findings provide a rational basis for more detailed and expanded studies in mice carrying mutations implicated in ASDs to determine whether the therapeutic benefits of soluble epoxide hydrolase inhibitor(s) observed in this study are more generalizable.”

Autism: 1 of 68 Children
The Center for Disease Control and Prevention (CDC) estimates that 1 in 68 children in the United States have autism, commonly diagnosed around age 3. It is four times more common in boys than girls. CDC defines autism spectrum disorder as a “developmental disability that can cause significant social, communication and behavioral challenges.” The disorder impairs the ability to communicate and interact.

Schizophrenia: 1.2 Percent of Population
Approximately 3.5 million people or 1.2 percent of the population in the United States are diagnosed with schizophrenia, one of the leading causes of disability, according to the Schizophrenia and Related Disorders Alliance of America (SARDAA). Scores more go unreported. Approximately three-quarters of persons with schizophrenia develop the illness between 16 and 25 years of age. Statistics also show that between one-third and one half of all homeless adults have schizophrenia, and 50 percent of people diagnosed have received no treatment. Among the symptoms: delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, and obsessive-compulsive disorders, such as hoarding, according to SARDAA.

In their research paper, titled “Key Role of Soluble Epoxide Hydrolase in the Neurodevelopmental Disorders of Offspring After Maternal Immune Activation,” the scientists described sEH as “a promising prophylactic or therapeutic target for neurodevelopmental disorders in offspring after MIA.”

First author Min Ma and second Qian Ren of the Hashimoto lab conducted the animal and biochemical work, while chemists Jun Yang and Sung Hee Hwang of the Hammock lab performed the chemistry and analytical chemistry. Takeo Yoshikawa, a team leader with the RIKEN's Molecular Psychiatry Laboratory, performed measurements of gene expression in the neurospheres from iPSC (induced pluripotent stem cells) from schizophrenia patients and postmortem brain samples from autism patients.

Exciting and Productive
Hashimoto described the international collaboration as “exciting and productive.” This is their third PNAS paper in a series leading to endoplasmic reticulum stress. “We report discovery of a biochemical axis that leads to multiple neurological disorders, including depression, Parkinson's disease, schizophrenia, autism spectrum disorders and similar diseases,” he said.

William Schmidt, vice president of clinical development at EicOsis, a Davis-based company developing inhibitors to sEH to treat unmet medical needs in humans and companion animals, said the company is devel​oping a first-in-class therapy for neuropathic and inflammatory pain. “EicOsis is in the process of finalizing our first human trials on the inhibitors of the soluble epoxide hydrolase, originally reported from UC Davis,” Schmidt said. “We are targeting the compounds as opioid replacements to treat peripheral neuropathic pain. It is exciting that the same compound series may be used to prevent or treat diseases of the central nervous system.”

Several grants from the National Institutes of Health, awarded to Hammock, supported the research. Hammock praised the many collaborators and students he has worked with on the project. “This work illustrates the value of research universities in bringing together the diverse talent needed to address complex problems,” Hammock said. “It also illustrates the value of fundamental science. This autism research can be traced directly to the fundamental question of how caterpillars turn into butterflies.”