Wait, there's more! "Not So Heartless: Functional Integration of the Immune and Circulatory Systems of Mosquitoes."
This may not be the proverbial heart-stopping seminar, but it promises to be an eye opener by a medical entomologist and captivating speaker.
Julián Hillyer, associate professor of biological sciences, Vanderbilt Institute for Infection, Immunology and Inflammation, Nashville, Tenn., will deliver that seminar at 4:10 p.m., Wednesday, Oct. 23, in 122 Briggs Hall, as part of the weekly UC Davis Department of Entomology and Nematology seminars.
"Mosquitoes--like all other animals--live under constant threat of infection," Hillyer says in his abstract. "Viral, bacterial, fungal, protozoan and metazoan pathogens infect mosquitoes through breaches in their exoskeleton and following ingestion. Because these pathogens pose a threat to their survival, mosquitoes have evolved a powerful immune system."
In his seminar, Hillyer will present his laboratory's work characterizing the circulatory and immune systems of the African malaria mosquito, Anopheles gambiae. "Specifically," he says. "the talk will describe the structural mechanism of hemolymph (insect blood), circulation in different mosquito life stages, and the role that immune cells, called hemocytes play in the killing of pathogens by phagocytosis, melanization and lysis. Then I will describe the functional integration of the circulatory and immune systems a process that is manifested differently in larvae and adults. Specifically, the infection of an adult mosquito induces the aggregation of hemocytes at the abdominal ostia (valves) of the heart--where they sequester and kill pathogens in areas of high hemolymph flow--whereas the hemocytes of larvae aggregate instead on respiratory structures that flank the posterior in current openings of the heart."
"This research," Hillyer explains, "informs on the physiological interaction between two major organ systems and uncovers parallels between how the organ systems of invertebrate and vertebrate animals interact during the course of an infection."
What does the mosquito heart look like? Check out former Vanderbilt graduate student Jonas King's prize-winning image--a fluorescent image of the heart of a mosquito. It won first place in Nikon's "Small World'" photomicrography competition in 2010. King's image shows a section of the tube-like mosquito heart magnified 100 times. At the time he was a member of Hillyer's research group and is now an assistant professor at Mississippi State University.
In a piece by David Salisbury of Vanderbilt News, Hillyer related that "Surprisingly little is known about the mosquito's circulatory system despite the key role that it plays in spreading the malaria parasite. Because of the importance of this system, we expect better understanding of its biology will contribute to the development of novel pest- and disease-control strategies.”
"The mosquito's heart and circulatory system is dramatically different from that of mammals and humans," wrote Salisbury in the Oct. 15, 2010 piece. "A long tube extends from the insect's head to tail and is hung just under the cuticle shell that forms the mosquito's back. The heart makes up the rear two-thirds of the tube and consists of a series of valves within the tube and helical coils of muscle that surround the tube. These muscles cause the tube to expand and contract, producing a worm-like peristaltic pumping action. Most of the time, the heart pumps the mosquito's blood—a clear liquid called hemolymph—toward the mosquito's head, but occasionally it reverses direction. The mosquito doesn't have arteries and veins like mammals. Instead, the blood flows from the heart into the abdominal cavity and eventually cycles back through the heart."
“The mosquito's heart works something like the pump in a garden fountain,” Hillyer told Salisbury.
Hillyer was a Vanderbilt Chancellor Faculty Fellow (2016-2018) and was awarded the 2015 Henry Baldwin Ward Medal by the America Society of Parasitologists. He was elected to the Council of the American Society of Parasitologists, serving from 2012-2016. Other recent awards: the 2011 Jeffrey Nordhous Award for Excellence in Undergraduate Teaching and the 2012 Recognition Award in Insect Physiology, Biochemistry and Toxicology from the Southeastern Branch of the Entomological Society of America.
Hillyer received his master's degree and doctorate from the University of Wisconsin-Madison under the mentorship of Ralph Albrecht and Bruce Christensen, respectively. He completed a postdoctoral fellowship under the mentorship of Kenneth Vernick at the University of Minnesota, now with Institut Pasteur. In 2007, Hillyer moved to Nashville, Tenn. to establish Vanderbilt University's mosquito immunology and physiology laboratory. (See more.)
The Hillyer Lab is interested in basic aspects of mosquito immunology and physiology, focusing on the mechanical and molecular bases of hemolymph (blood) propulsion, and the immunological interaction between mosquitoes and pathogens in the hemocoel (body cavity)," according to his website. "Given that chemical and biological insecticides function in the mosquito hemocoel, and that disease-causing pathogens traverse this compartment prior to being transmitted, we expect that our research will contribute to the development of novel pest and disease control strategies."
Host is Olivia Winokur, doctoral student in the Chris Barker lab. Community ecologist Rachel Vannette, assistant professor, Department of Entomology and Nematology, coordinates the weekly seminars. (See list of seminars)
When the United Nations meets Sept. 21 in New York, they want the UN to reframe its action on the global antimicrobial drug resistance (AMR) crisis.
It's crucial. How crucial is it?
Antimicrobial drug resistance threatens both personal and planetary health and the issue is as crucial as the global threat of climate change, Carroll says.
In a paper titled “Use Antimicrobials Wisely,” published in the current edition of Nature, a nine-member international research team, including Carroll, explained their advocacy.
“We're concerned about what will happen if the proposed UN solutions focus mainly on incentives for new drug development, at a time when the drug industry itself is abandoning those efforts against infectious disease due to AMR,” said Carroll, who co-leads the international group on resistance to pesticides and antimicrobial drugs. He founded and directs the Institute for Contemporary Evolution, Davis, and is affiliated with the Sharon Lawler lab, UC Davis Department of Entomology and Nematology.
The paper, published in the Comment section, is the first product from a two-year working group sponsored by the National Socio-Environmental Synthesis Center in Annapolis, Md. “We are taking a similar socio-environmental approach in our concurrent work on pesticide stewardship,” Carroll said.
“While new drugs have a role, we think it's more important for society to learn how to steward pathogen susceptibility, so we develop that theme in the paper,” Carroll said. “And because we also depend on microbes for digestion, immunity, and general health, and microbes support ecosystem functioning through nutrient cycles and the maintenance of soil and water quality, we further argue that our AM drug habits and waste streams threaten both personal and planetary health. “
Lead authors of the paper are Peter Jorgensen of Stockholm, Sweden, and Didier Wernli of Geneva Switzerland. Jørgensen, who spent part of his Danish graduate program working with Carroll in Davis, is now a postdoctoral researcher at the Royal Swedish Academy of Science, Stockholm.
Carroll described AMR as more than a medical dilemma—it's a socio-ecological problem. “The vulnerability of pathogens to antimicrobial drugs is a communal resource, readily threatened by overuse, to be lost as a classic 'tragedy of the commons.' There is a lot of contemporary theory for social resilience in the face of socio-ecological challenges, and– linking to entomology– the early success of the pioneering management of Bt crop pest resistance evolution is an encouraging precedent.”
In its planetary health approach, the group seeks to be “more cognizant not only of preserving drug susceptibility in pathogenic microbes, but also protecting from wholesale destruction the community of microbes on which we depend for life,” Carroll said.
In the paper, the scientists pointed out that “Resistance affects animal and environmental health as well as human health, and so requires coordinated action across economic sectors. No single concern exemplifies this better than the high rate of antibiotic use in agriculture (largely as growth promoters or disease prevention).” They wrote that in the United States, 70 to 80 percent of all anti-microbials consumed are given to livestock.
An example of antimicrobial resistance involves the malaria mosquito, Anopheles gambiae. The World Health Organization (WHO) in a document, "Global Action Plan on Anti-Microbial Resistance," wrote:
"Antimicrobial resistance can affect all patients and families. Some of the commonest childhood diseases in developing countries – malaria, pneumonia, other respiratory infections, and dysentery – can no longer be cured with many older antibiotics or medicines. In lower- income countries, effective and accessible antibiotics are crucial for saving the lives of children who have those diseases, as well as other conditions such as bacterial blood infections. In all countries, some routine surgical operations and cancer chemotherapy will become less safe without effective antibiotics to protect against infections."
Expect to hear more about this alarming crisis--the global antimicrobial drug resistance crisis. Meanwhile, read the WHO Global Action Plan.
You don't usually see "honey bees" and "malaria" in the same sentence.
That won't be the case, though, when Joseph DeRisi, a Howard Hughes Medical Institute investigator and professor and vice chair of the Department of Biochemistry and Biophysics, University of California, San Francisco, comes to the UC Davis campus to lecture on Monday, Jan. 9.
His presentation, "A Seminar in Two Acts: Honey Bees and Malaria," is from 10 to 11 a.m. in the main auditorium (Room 2005) of the Genome and Biomedical Sciences Facility.
The seminar, open to all interested persons, is sponsored by the Biological Networks Focus Group of the Genome Center. Host is Oliver Fiehn, professor in the Department of Molecular and Cellular Biology and the Genome Center.
DeRisi, a molecular biologist and biochemist, was named the recipient of a MacArthur Foundation Grant (also known as "the genius award") in 2004. In 2008, DeRisi won the Heinz Award for Technology, the Economy and Employment. Among his many accomplishments: he designed and programmed a groundbreaking tool for finding (and fighting) viruses -- the ViroChip, a DNA microarray that test for the presence of all known viruses in one step.
The DeRisi lab drew international attention last year with publications in Public Library of Science journals.
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum (published in PLoS Biology, August 2011)
Temporal Analysis of the Honey Bee Microbiome Reveals Four Novel Viruses and Seasonal Prevalence of Known Viruses, Nosema, and Crithidia (published in PLoS One, June, 2011)
Among those working on the honey bee research and co-authoring the PLoS One paper was insect virus researcher Michelle Flenniken, a postdoctoral fellow in the Raul Andino lab at UC San Francisco and the recipient of the Häagen-Dazs Postdoctoral Fellowship in Honey Bee Biology at UC Davis.
Among DeRisi's collaborators on malaria research is UC Davis molecular biologist Shirley Luckhart, professor in the Department of Medical Microbiology and Immunology and an advisor in the Entomology Graduate Program.
DeRisi, who received his Ph.D. in biochemistry in 1999 from Stanford University, does amazing work.
He's a genius, to be sure.
Check out these links:
Joseph DeRisi Lab, UC San Francisco
Joe DeRisi: Biochemist (featured in TED ("Technology, Entertainment, Design" is a nonprofit devoted to Ideas Worth Spreading.)
Conversation with Joe DeRisi (New York Times)
Solving Medical Mysteries (YouTube)
Hunting the Next Killer Virus (YouTube)
Joseph DeRisi: Howard Hughes Medical Institute
Joseph DeRisi in Wikipedia
Those malaria mosquitoes may have met their match--with researchers at the University of California, Davis.
UC Davis entomology doctoral candidate Ashley Horton, recent winner of the 2010 Arthur J. and Dorothy D. Palm Agricultural Scholarship, focuses her research on how mosquitoes transmit malaria.
Horton studies with major professor Shirley Luckhart, professor in the Department of Medical Microbiology and Immunology and researches how the immune system of the malaria mosquito, Anopheles gambiae, affects the transmission of the Plasmodium parasite, the causative agent of malaria.
Malaria kills more than a million people a year, primarily in Africa.
“Ashley’s work that was recently published in Malaria Journal, together with our co-authors and collaborators Dr. Yoosook Lee and Dr. Gregory Lanzaro, is the first to identify mutations in immune signaling genes that exhibit associations with natural infection with Plasmodium falciparum in field-collected Anopheles gambiae mosquitoes in Mali," Luckhart said. "Plasmodium falciparum is the most important human malaria parasite in Africa and this work is necessary as a foundation to assess whether genetic control measures to block transmission of this parasite will be possible in malaria-endemic countries.”
The research, titled "Identification of Three Single Nucleotide Polymorphisms in Anopheles gambiae Immune Signaling Genes that are Associated with Natural Plasmodium falciparum Infection," appears in the June 10, 2010 edition of Malaria Journal.
Horton, who received her bachelor's degree in public health studies at The Johns Hopkins University, Baltimore, joined the UC Davis Entomology Graduate Program in 2005. In 2008 she received a William Hazeltine Student Research Fellowship, an award in memory of a noted California entomologist.
The Palm scholarship supplements her fellowship support from a National Institutes of Health T32 training grant that is managed by director Lanzaro and associate director Luckhart.
Arthur Palm, an alumnus of UC Davis, received his bachelor's degree in agricultural economics in 1939. He and his wife established the endowed fund to support undergraduate and graduate students.
The Palm family and others who fund scholarships not only support our university students; they support public health issues.
They, too, are tackling malaria.
Peter F. Billingsley (right), senior director of Entomology and Quality Systems at Sanaria Inc., Rockville, Md., will speak on "Development of a Mosquito-Derived, Attenuated Whole Parasite Vaccine against Malaria" on Friday, Dec. 3.
His talk--from 12:10 to 1 p.m. in the UC Davis Genome Center Auditorium, 1005 Genome and Biological Sciences Facility, 451 Health Sciences Drive--is part of the UC Davis Department of Medical Microbiology and Immunology Seminar Series, "Emerging Challenges in Microbiology and Immunology." It's also affiliated with the UC Davis Department of Entomology fall seminar series.
Host is Shirley Luckhart, associate professor of medical microbiology and immunology, who studies the malaria mosquito, Anopheles gambiae. Luckhart's many roles include serving as a graduate student advisor in the Department of Entomology.
Sanaria? It's a self-described "biotechnology company dedicated to the production of a vaccine protective against malaria caused by the pathogen Plasmodium falciparum."
Billingsley has more than 20 years experience in medical entomology and malaria transmission research. He directed research teams at Imperial College, London, and the University of Aberdeen, Scotland, examining diverse aspects of insect biology related to disease transmission, especially midgut and salivary gland biology, and more recently the molecular physiology of aging in mosquitoes.
Billinglsey, who earned his doctorate at Queen’s University in Canada, is a former head (chair) of zoology in the School of Biological Sciences, Aberdeen University.
Since 2006, he has devoted his broad expertise to the unique challenges of developing and deploying a live attenuated Plasmodium falciparum sporozoite vaccine at Sanaria Inc.
Billingsley's talk is generating a lot of interest, as well it should.
According to the Centers for Disease Control and Prevention (CDC), malaria kills more than a million people a year: "In 2008, an estimated 190 - 311 million cases of malaria occurred worldwide and 708,000 - 1,003,000 people died, most of them young children in sub-Saharan Africa."