- Author: Kathy Keatley Garvey
The award consists of a $2,000 honorarium and a commemorative medal. His work will be published in the journal Drug Metabolism and Disposition.
A member of the UC Davis faculty since 1980, Hammock will receive the award April 28 during the joint annual meeting of the ASPET and the Chinese Pharmacological Society, set for April 26-30 in San Diego. He will present a keynote speech about his research.
The award recognizes Hammock’s outstanding original research contributions to the understanding of human drug metabolism and transport and the continued impact of his research in the area of drug discovery and development.
Hammock, who directs a laboratory of more than 40 scientists and students in the UC Davis Department of Entomology and Nematology, explores the biochemical basis of human and environment interactions and their implications for improving both human and environmental health.
For more than 35 years, Hammock has worked on the mechanism of certain hydrolytic enzymes and their effect on human health. His work has helped identify new targets for the action of drugs and other compounds to improve health and predict risk from various environmental chemicals.
In selecting Hammock, ASPET acknowledged Hammock’s collaborative studies in drug metabolism and metabolomics. The society also noted his tradition of sharing reagents for research to enable investigators in both the private and public sectors to make substantial advances for the development of potentially useful therapeutic compounds to treat stroke, atherosclerosis, heart failure, renal failure, inflammation and neuropathic pain.
Hammock is best known for his work on epoxide hydrolases and in particular, the soluble epoxide hydrolase (sEH), but also has made major contributions to the esterase field and other enzymes involved in drug metabolism. He has received many awards for his work in agriculture, toxicology and chemistry.
Hammock directs the campuswide Superfund Research Program, National Institutes of Health Biotechnology Training Program, and the National Institute of Environmental Health Sciences (NIEHS) Combined Analytical Laboratory. He is a fellow of the Entomological Society of America, a member of the prestigious National Academy of Sciences, and the recipient of the 2001 UC Davis Faculty Research Lecture Award and the 2008 Distinguished Teaching Award for Graduate and Professional Teaching.
Hammock received his bachelor of science degree magna cum laude from Louisiana State University in entomology and chemistry and his doctorate from UC Berkeley in entomology and toxicology, working in xenobiotic metabolism.
KEY DISCOVERIES ON sEH FROM HAMMOCK LABORATORY
- Discovery of sEH (1972)
- First rapid radiochemical assay methods (1979, 1980)
- First spectral and fluorescent assays for the enzyme (1982, 1988, 1994)
- Fluorescent high throughput assay for screening (2005, 2006)
- First high throughput screen (90,000 compound National Institutes of Health library) (2007, PubChem)
- Initial determination of substrate selectivity (1979, 1980)
- Discovery that fatty acid epoxides are good substrates for sEH (1979)
- Discovery that PPAR alpha agonists induce the sEH (1983)
- Development of first antibodies to sEH (1981)
- Development of 1 step affinity purification procedure for sEH (1985, 1988)
- Cloning and expression of rodent and human sEH cDNA (1993)
- First cloning, expression and characterization of a plant sEH (1994)
- Cloning of first sEH gene (1994)
- First irreversible inhibitors (1982)
- Discovery that arachidonate epoxides are substrates of sEH (1983)
- First study of regio and stereospecificity of enzyme (1980, 1993)
- Regio and enantiospecificity of sEH with epoxyeicosanoids (1993)
- First isolation of substrate-enzyme complex (1994)
- Elucidation of the catalytic mechanism of epoxide hydrolases (1995)
- Discovery that linoleate diols are chemical mediators (1997)
- Blocking linoleate epoxide toxicity with EH inhibitors (1998)
- X-ray structure of the sEH (1999)
- Discovery of first transition state mimics of EH (1999)
- Reduction of blood pressure in vivo with sEH inhibitors (sEHI) (2000)
- Development of the first potent mEH inhibitors (2001)
- Characterization of eicosanoid profiles by LC-MS including EETs (2002)
- Demonstration that sEH is a divalent enzyme with lipid phosphatase activity (2003)
- Demonstration that sEHI can treat rodent models of chronic pulmonary obstructive disease (copd) and lipopolysaccharide induced sepsis (2005)
- Demonstration that sEHI shift the entire arachidonate cascade from a pattern of initiation of inflammation to a pattern of resolution of inflammation (2005)
- Founded a company and acquired funding to develop sEHI clinically (2005)
- Demonstrated sEHI synergize COX inhibitors and reduce thromboxanes (2006)
- Optimized picomolar sEHI with good ADME in rodent, canine and primates (2007)
- Demonstration sEHI synergize LOX and FLAP inhibitors (2007)
- Demonstration sEHI are strongly analgesic (2007)
- Demonstration that sEHI are strongly analgesic with neuropathic pain (2008)
- Successful treatment of diabetic neuropathic pain with sEH inhibitor in double blind cross over trial (2012)
- Demonstration that the ω-3 epoxide, DHA, is more potent at reducing blood pressure, pain, and inflammation than ω-6 ARA (2011-13)
- Demonstration that DHA epoxide reduces angiogenesis, tumor growth and metastasis (2013)
- The sEHI and other compounds from the Hammock laboratory have been used to dissect the basic biology of the P450 branch of the arachidonate cascade and to identify numerous clinical targets ranging from cardiovascular disease to diabetes.
ASPET is a 4800-member scientific society whose members conduct basic and clinical pharmacological research in academia, industry and the government. Their efforts help develop new medicines and therapeutic agents to fight existing and emerging diseases.
Last year’s Brodie Award recipient was Yuichi Sugiyama of the University of Tokyo, a world leader in the pharmacological and pharmaceutical sciences via integrative studies on the pharmacokinetics and membrane transport of drugs.
- Author: Kathy Keatley Garvey
His interest in “all things bugs” stemmed from his entomologist father, Bruce Hammock, now a distinguished professor at the University of California, Davis.
It was not just entomology and art, though, that interested Tom. He listened attentively to the southern folklore and childhood memories that his father, reared in the Deep South, shared:
Black-eyed peas on New Year’s Day for good luck; a mischievous pet raccoon named Willy; the comings and goings of a scientist operating a biological supply company in a swamp; and
the ever-present will-o’-the-wisp lighting up Louisiana’s Atchafalaya Swamp.
Tom Hammock not only drew it all in; he made it his own and then some.
Entomology and art, pyramided with writing, landscape architecture, film production and storytelling, evolved into an original graphic novel, “An Aurora Grimeon Story—Will O’ the Wisp,” authored by Tom Hammock, illustrated by his friend Megan Hutchison and edited by
“It’s about wicked delights and dark things,” said Tom, “and it has a girl-science component.” In fact, it is billed as the first graphic novel with a strong girl scientist as the main character. The publisher, Archaia, will release the book Jan. 28. It is already drawing rave reviews, including “This book shows the beginning of fine careers as creators of stories.”
It has already been nominated for "best young adult graphic novel" award from the American Library Association.
“Almost no one writes for girls and almost no one writes for girls dealing with girls and science,” Tom said. “Graphic novels for girls are rare and have a tough road in the publishing world.”
Assorted bugs, including butterflies, scorpions, fireflies, mosquitoes, beetles and spiders, find their way into the book. So does a pet raccoon named Missy, patterned after Bruce’s childhood pet, Willy.
“As a parent, it is always interesting to see what your kids pick up in their childhood,” said Bruce Hammock, a Little Rock, Ark. native who graduated in 1969 from Louisiana State University (LSU) and then obtained his doctorate in entomology/toxicology from UC Berkeley. “I think my Willy stories were recreated in the tale about Aurora.”
Aurora’s last name is Grimeon, named for one of Bruce’s LSU roommates, Jim Grimeon. “I am so thrilled that so much of this history,” Bruce said, “has resurfaced in Tom’s book.”
Aurora, accompanied by Missy the raccoon, explores the fog-shrouded island as “ghostly things happen and residents disappear,” Tom said. Aurora follows a will ‘o’ the wisp, an eerie blue light floating several feet off the ground. “The will-o’-wisp is a natural phenomenon,” Tom said. “It’s actually a natural swamp gas.”
Quipped Bruce: “I never knew that my family in Arkansas practiced hoodoo—I thought everyone ate black-eyed peas, hog jowl and burned a bayberry candle on New Year’s Day. We still do.”
Bruce and his wife, Lassie, reared their three offspring to love nature. “The Atchafalaya certainly is as much a wilderness as the Sierra Nevada with islands that move with the tides, different cultures, and a rich biological diversity—much of which bites,” said Bruce, who holds a joint appointment with the UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center.
“Tom has always had a love of biology and landscape,” Bruce said. “He was always sketching nature in his childhood. He could not stand to kill insects for his high school insect collection so instead, he made exquisite drawings of insects that he captured.”
Tom, a 1994 graduate of Davis High School, initially studied biology at UC Berkeley and then switched to landscape architecture. After receiving his bachelor’s degree in landscape architecture, he left Berkeley to study film design at the American Film Institute. He then went on to work in such film productions as “Breaking Bad,” “Dexter,” “Charlie and the Chocolate Factory.” He is now involved in the hugely popular young adult and horror film genre.
“At first I wanted to be a scientific illustrator,” Tom said. He took private art lessons from Mary Foley Benson of Davis, former chief USDA scientific illustrator at the Smithsonian Natural History. Her work graces Bruce Hammock's office in Briggs Hall and in a conference room.
The Hammock family is a three-doctorate family. In addition to Bruce the entomologist, son Bruce (UC Davis doctorate), is an aquatic entomologist in the UC Davis School of Veterinary Medicine, and daughter Frances (UCLA doctorate), is a mathematician in San Diego.
Tom, known for his sense of humor, wrote in his biography published on Oscillary Isle website: “My father studies venoms, insects and other odd creatures. As such, most family vacations were spent in the wilderness, often hunting for previously said creatures and their venoms. I've lived a number of places around the world including, but not limited to Australia (home of many venomous creatures) and England (home of not so many venomous creatures.)"
"Presently I live in Hollywood where I drink tea and design films when I'm not writing graphic novels." Some of the films he’s designed include “You're Next,” “All The Boys Love Mandy Lane,” and “V/H/S 2.”
Tom’s parents, Bruce and Lassie, appeared in a 2013 movie that Tom directed and produced. The film, as yet untitled, is expected to be released sometime this year.
“I watched a lot of movies in my childhood,” said Tom, who remembers growing up without a TV or with a black and white TV in high school. One of his favorite films? “Blade Runner.”
Tom recalls working on the film, Dexter, and blowing up a boat. “Then when we arrived at the airport they wouldn’t let us on the plane because of the residue on our hands.”
Meanwhile, Tom Hammock and Megan Hutchison are excited about the graphic novel and pleased with the design. It resembles a diary, complete with lock, and is printed with a gold foil-embossed hard cover. “It looks as if it belongs in Silver’s old library of curiosities,” Tom said.
They are also growing increasingly fond of their adventuresome, strong and science-loving character, Aurora. They are eagerly looking forward to Part 2 of the trilogy.
So are the fans. One online comment: “"OMG!! This was so good. I hope and hope and hope there will be more!!!!"
Another commented: "I love Aurora and everything about this story. The art is fantastic. 10 out of 10.”
Others described it as “deliciously moody,” “impressively creepy” and “a blend of macabre and whimsy (which) makes for some fun and unexpected reading.”
Looking back, entomologist Bruck Hammock said: "Tom was always interested in landscape, art, and biology. However, film and graphic novels are so far from my background I never saw this as a career path. In retrospect it is obvious."
For more information:
Website: http://www.ossuaryisle.com
Book Trailer: http://www.ossuaryisle.com/trailer.html
Preview, PDF: http://ossuaryisle.com/preview.pdf
Facebook: https://www.facebook.com/ossuaryisle
Preview by Comic Book Resources: http://www.comicbookresources.com/?page=preview&id=18246
Goodreads.com: https://www.goodreads.com/book/show/18125353-will-o-the-wisp
Amazon: http://www.amazon.com/Will-Wisp-Aurora-Grimeon-Hammock/dp/1936393786
YouTube: https://www.youtube.com/watch?v=cZf1wJDMSG0
Trending tweets: #WILLOtheWisp
- Author: Kathy Keatley Garvey
"Crop protection in cotton against arthropod pests has historically been mono-tactical and dominated by the use of broad-spectrum insecticides," Naranjo says. "It has also been known for a long time that cotton harbors a rich community of natural enemies, particularly generalist arthropod predators, which have the capacity to suppress numerous pests. Here, I will focus on advances in the Arizona cotton system, which has enabled biological control to become a critical tactic in IPM and driven insecticide use to historical lows."
"A key element has been the deployment of integrated control, an innovative concept introduced over 50 years ago by a group of UC entomologists that calls for the interplay of chemical and biological control for pest management. I will provide an overview of a large research effort involving classical and conservation biological control, selective insecticides, transgenic cotton, and decision aids that have transformed cotton IPM and provided a rare example of true integrated control."
Naranjo, as the director of the Arid-Land Agricultural Research Center, oversees a broad research program focused on crop production and protection of arid-land crops. He is internationally recognized for his research in insect sampling and decision aids, integrated pest management (IPM), conservation biological control, insect population ecology, and environmental risk assessment of transgenic crops. He is president of the Pacific Branch, Entomological Society of America.
He received his doctorate in entomology in 1987 from Cornell University, his master's degree in entomology in 1983 from the University of Florida, and a bachelor's degree in 1978 in zoology from Colorado State University. He has authored more than 200 scientific papers, books, and book chapters, technical reports and extension bulletins, and has presented more than 100 invited papers and seminars at professional conferences, symposia, and academic institutions.
Naranjo served as co-editor-in-chief of the international journal, Crop Protection, from 1995-2006 and currently serves as subject editor for Environmental Entomology, covering the topic area of transgenic plants and insects.
Naranjo holds an adjunct appointment in the University of Arizona's Department of Entomology. He has recevied numerous awards and honors, including the UDSA-ARS Early Career Scientist of the Year; the C. W. Woodworth Award from the Pacific Branch of the Entomological Society of America (ESA); and the ESA Recognition Award in Entomology. In addition, his team won the Entomological Foundation IPM Team Award.
- Author: Kathy Keatley Garvey
Six biological museums will open their collections to the public at the third annual UC Davis Biodiversity Day, set Saturday, Feb. 8.
The event, to be held from noon to 4 p.m., will showcase collections of the Bohart Museum of Entomology, the Museum of Wildlife and Fish Biology, the Botanical Conservatory, the Center for Plant Diversity, the Anthropology Collections, and the Paleontology Collections.
It's an opportunity to see "see carnivorous plants, touch fossils, learn about birds and hold insects," said Tabatha Yang, outreach and education coordinator at the Bohart Museum. More than 1000 people turned out for this event last year.
Free and open to the public, it's a family friendly event. Parking is free as well.
- Author: Kathy Keatley Garvey
And “millipede patrol.” And “powderpost beetle patrol.”
Kimsey, whose fly research on the island led to his nickname, “The Fly Man of Alcatraz,” will be leading 16 club members Saturday on an overnight insect/arthropod collecting tour, deploying insect light traps. They also will be surveying the rat population that threatens the bird sanctuaries on the island.
The project encompasses all of Saturday and part of Sunday. “Some in our group want to get back early so as not to miss the game,” said Kimsey, a faculty member of the UC Davis Department of Entomology and Nematology and the club’s advisor.
Kimsey knows that the Seattle team’s bird moniker is “Seahawks,” but he’s more interested in other birds--the birds in the island’s rookeries and the “The Bird Man of Alcatraz” (Robert Stroud)-- than in who’s throwing the pigskin.
“I’m not a football fan,” Kimsey acknowledged.
A UC Davis “rat patrol” in February of 2012 led to the discovery of a fluorescent millipede, a common arthropod but previously unknown to exist on the island. After National Park Service employees fed rats a bait laced with fluorescent, non-toxic dye, Kimsey and the club members began searching for fluorescent rat feces.
Had it consumed some of the rat bait? No. An experiment at the Bohart Museum of Entomology on the UC Davis campus showed that these millipedes (Xystocheir dissecta (Wood) glow under ultraviolet or black lights, just like scorpions.
Lynn Kimsey, director of the Bohart Museum of Entomology and UC Davis professor of entomology, suspects that the millipedes on Alcatraz Island originated from soil transported over from the nearby Angel Island when “The Rock” was just that—rock with little or no soil.
The species is relatively abundant in the Bay Area. “This particular species of millipedes glowed all along, but nobody was paying any attention to it,” she said.
Nguyen is now doing research in the Bruce Hammock lab on the florescent millipedes. He wants to know what compound makes the millipede fluoresce under a UV light.
This will be Nguyen’s fourth overnight trip to The Rock. “I’m very excited to return,” he said.
The former maximum-security federal penitentiary once housed some of the country's most notorious inmates including not only “The Bird Man of Alcatraz” but Al “Scarface” Capone, George “Machine Gun” Kelly, and Arthur “Doc” Barker.
Robert Kimsey does research on the nuisance flies that plague staff and tourists on Alcatraz. He became involved in the fly project in July 2007 when he received a call about the annoying flies from entomologist Bruce Badzik, integrated pest management coordinator with the National Park Service, Golden Gate National Recreation Area. Since then, they have worked on a number of projects involving UC Davis Entomology Club members.
So while the 49’ers and Seahawks collect first downs, touchdowns and field goals, entomologists Robert Kimsey and Bruce Badzik and the UC Davis students will be collecting millipedes, beetles and other arthropods.
And doing “rat patrol.”