Glyphosate was commercialized in 1974. Since then, it has become one of the most widely used and studied herbicides. According to Duke (2018b), almost 20,000 scientific publications and patents have included glyphosate as a focus; only 2,4-D surpasses it with respect to citations. The articles in the 5^th issue of the 74^th volume of Pest Management Science are no different; they all focus on this important (and controversial) molecule.This special issue arose from a day long symposium organized by Stephen O. Duke (University of Mississippi) and Keith Solomon (University of Guelph) that was held at the 252^nd annual meeting of the American Chemical Society (Duke 2018a).