- Author: Kathy Keatley Garvey
That's the title of a poster next to the door of the Bohart Museum of Entomology, located in Room 1124 of the Academic Surge Building, 455 Crocker Lane, UC Davis.
The poster specifies possible careers, listing pollinators, medical, genomics, animal behavior, forensics, environmental protection, public health, evolution, pest biology, invasive biology, pest biology, biotechnology, forest entomology, agriculture, aquatic entomology, vector biology, conservation and new species discovery.
Images of California's state insect, the California dogface butterfly, Zerene eurydice, decorate the poster. The butterfly is also the featured insect in the Bohart Museum's logo.
Not to be left out, someone from the nearby laboratory of arachnologist Jason Bond added to the "Why Study Insects" poster: "Arachnids!" Yes, let's study arachnids, too! Bond is the Evert and Marion Schlinger Endowed Chair, UC Davis Department of Entomology and Nematology, and associate dean, UC Davis College of Agricultural and Environmental Sciences. And he's the president-elect of the American Arachnological Society. (See news story)
The Entomological Society of America (ESA) defines entomology as the study of insects. "Entomologists study bees, ants, beetles, termites, mosquitoes, and other insects, as well as other related animals (known as arthropods), such as spiders and scorpions...While it has been estimated that there are as many as 30 million species of insects on the planet Earth, only about one million have actually been discovered and described."
Another factoid from ESA: "Many animals, such as birds, fish, and snakes, eat insects, so they are an important part of the food chain. And without insect pollinators, global vegetation would largely collapse. At the same time, other insects are important decomposers — they eat dead plants and animals, which releases nutrients back into the soil so that new plants and animals can grow. Still other insects are parasites or predators, and they help control the populations of other species. Entomologists study insects and other animals in their habitats, which teaches us how to preserve and restore natural ecosystems."
How many insects are there in the world? According to the Smithsonian Institute, "there are some 10 quintillion (10,000,000,000,000,000,000) individual insects alive."
"In the United States, the number of described species is approximately 91,000," the Smithsonian says. "The undescribed species of insects in the United States, however, is estimated at some 73,000. The largest numbers of described species in the U.S. fall into four insect Orders: Coleoptera (beetles) at 23,700, Diptera (flies) at 19,600, Hymenoptera (ants, bees, wasps) at 17,500, and Lepidoptera (moths and butterflies) at 11,500."
"Recent figures indicate that there are more than 200 million insects for each human on the planet! A recent article in The New York Times claimed that the world holds 300 pounds of insects for every pound of humans."
Another factoid from the Smithsonian: "Most authorities agree that there are more insect species that have not been described (named by science) than there are insect species that have been previously named. Conservative estimates suggest that this figure is 2 million, but estimates extend to 30 million."
"While it has been estimated that there are as many as 30 million species of insects on the planet Earth, only about one million have actually been discovered and described."
So, we're not running out of insects any time soon!
The Bohart Museum of Entomology, directed by UC Davis distinguished professor Lynn Kimsey, houses a global collection of eight million insect specimens. It is part of the UC Davis Department of Entomology and Nematology, ranked as one of the nation's leading entomology departments. Department chair is Professor Joanna Chi, a molecular geneticist-physiologist. Vice chair is associate professor Rachel Vannette, a community ecologist.
- Author: Kathy Keatley Garvey
Leal, a leading global scientist and inventor in the field of insect olfaction and communication, is known for his impact in the fields of molecular, cellular biology and entomology.A member of RES since 2008, he was named a Fellow of RES in 2009 and Honorary Fellow in 2015.
The organization, founded in 1833 in London, is devoted to the understanding and development of insect science, and supporting international collaboration, research and publication. It aims “to show every person how remarkable and valuable insects are,” RES officials said.
Leal said he plans to “hone in on new ways to develop and promote diversity and inclusivity,” and “to see our global entomological community bud, bloom and flourish.”
Leal, who joined the UC Davis entomology faculty in 2000, chaired the UC Davis Department of Entomology in 2006-2008 before accepting a position in 2013 as professor of biochemistry in the Department of Molecular and Cellular Biology. He chairs the Council of the International Congresses of Entomology, the body that ensures the continuity of the international congresses of entomology, succeeding May Berenbaum of the University of Illinois Urbana-Champaign.
“As a citizen of the world--born in Brazil, educated in Brazil and Japan, and honored as a Distinguished Professor with the University of California, Davis---I am eager to be serve as a trustee of the Royal Entomological Society and be part of the RES strategic plan to (1) move insect science forward internationally, (2) empower the global entomological community, and (3) to promote diversity and inclusivity,” Leal said.
His peers praise him for his contributions to insect science, including his teachings (he has taught insect physiology for almost 15 years); his internationally recognized research for his pioneering and innovative work in insect olfaction and communication; his publication record; his global entomological leadership; his administrative positions; and his commitment to serving humanity and engaging with scientists from all over the world.
Leal, named a UC Davis Distinguished Professor in 2016, co-chaired the 2016 International Congress of Entomology in Orlando, Fla., one of entomology's most prominent events (6,682 registrants from 102 countries).
He is a Fellow of the Entomological Society of America (2009), American Association for the Advancement of Science (2005), and the National Academy of Inventors (2019). He served as president of the International Society of Chemical Ecology, among other leadership activities.
During the COVID pandemic, Leal brought together the entomological and chemical ecology communities through various creative activities, including inventing and organizing a symposium, “Insect Olfaction and Taste in 24 Hours Around the Globe,” drawing thousands of participants from nearly 60 countries. He provided a platform for young scholars to highlight their recent work and interact with well-established scholars in the field.
Leal received his Ph.D. in applied biochemistry from the University of Tsukuba, Japan, with subsequent postdoctoral training in entomology and chemical ecology at the National Institute of Sericultural and Entomological Science and Cornell University, respectively. He was the first non-Japanese person to earn tenure at Japan's Ministry of Agriculture, Forestry, and Fisheries.
UC Davis and RES are closely connected. Peter Cranston, emeritus professor, UC Davis Department of Entomology and Nematology, became an Honorary Fellow of RES in 2010. Among the RES Fellows are emeriti professors Frank Zalom (a past president of the Entomological Society of America) and Phil Ward, both of the UC Davis Department of Entomology and Nematology, and Art Shapiro, emeritus professor, Department of Evolution and Ecology.
As of October 2018, there are approximately 1,689 living Fellows, Foreign and Honorary Members, of whom 85 are Nobel Laureates, according to Wikipedia. Among the notables are Sir David Attenborough, Honorary Fellow; and Charles Darwin, and Albert Einstein, Fellows. RES Fellowship has been described by The Guardian as "the equivalent of a lifetime achievement Oscar."
- Author: Kathy Keatley Garvey
"Ento-what?" some folks will ask. "What's that?"
Five-year-old Rebecca Jean "RJ" Millena could have told you.
She still can.
When she entered kindergarten in Concord, Calif., RJ penciled this on her "About Me" poster: "When I grow up, I want to be an entomologist."
To the amazement of her teacher and classmates, she even knew how to spell the five-syllable word referring to "the scientific study of insects."
Fast forward to today. She's 22, a senior majoring in entomology at the University of California, Davis, and an outstanding student researcher in the laboratory of UC Davis Distinguished Professor Jay Rosenheim of the Department of Entomology and Nematology.
And she's just accepted a four-year, full-ride fellowship offer to complete a doctoral program at the American Museum of Natural History. She will join the systematics laboratory of Dr. Jessica Ware after receiving her bachelor's degree from UC Davis in June.
In 2019, RJ was one of four UC Davis undergraduates selected for a two-year funded research career with the University of California Leadership Excellence through Advanced Degrees (UC LEADS) program, which prepares promising students for advanced education in science, technology, mathematics and engineering (STEM). The UC LEADS scholars embark upon a two-year program of scientific research and graduate school preparation.
Guided by Rosenheim, RJ launched her independent research project on those bizarre Strepsiptera endoparasites that attack their hosts, the Ammophila (thread-waisted) wasps.
RJ says that “being able to work with Jay on this project investigating the host-parasite relationship between Ammophila wasps and Strepsiptera was what made me fall in love with this super weird order of endoparasites." As larvae, members of the order Strepsiptera, known as “twisted wings,” enter their hosts, including wasps and bees, through joints or sutures.
Over a two-year period, she studied thousands of specimens at the Bohart Museum of Entomology. The UC Davis insect museum houses a worldwide collection of eight million specimens, including “about 30,000 specimens of Ammophila from multiple continents,” says director Lynn Kimsey, UC Davis professor of entomology. Global wasp authority and UC Davis doctoral alumnus Arnold Menke, author of the book, The Ammophila of North and Central America (Hymenoptera, Sphecidae), identified most of the Ammophila specimens in the Bohart Museum. His book is considered "the bible" of Ammophila research.
RJ went on to enter a poster, “Parental Care and the Risk of Maternally Vectored Pathogens: Ammophila Transmit Strepsipteran Parasites to Their Young,” in the March 2021 Koret UC LEADS Symposium poster competition and won top honors.
A dean's honor student with multiple interests, RJ plays French horn and trumpet in the UC Davis Video Game Orchestra. She performed two years with the California Aggie Marching Band-Uh. In her Davis apartment she tends to a colony of Madagascar hissing cockroaches, a scorpion, a tarantula, a tailless whip scorpion, and an African cat-eye mantis. “Over the last four years at UC Davis, I've had a colony of millipedes, two other tarantulas, a giant Vietnamese centipede, and five other assorted mantis species. The five-year-old me would also be thrilled about that.”
But back to what children want to be when they grow up. Usually they say cowboy, truck driver, cook, teacher, dancer, actor, musician, artist, athlete, firefighter, detective, writer, police officer, astronaut, pilot, veterinarian, lawyer, doctor and the like.
But rarely "entomologist."
RJ's highly contagious enthusiasm toward the scientific study of insects serves as a definite role model to young girls aspiring to careers in STEM. Women make up only 28 percent of the workforce in STEM, according to the American Association of University Women. RJ is closing the gender gap.
'I Wanna Be an Entomologist'
Back in 2011, we were delighted to see UC Davis Regents Scholar Heather Wilson, a researcher/lab technician in the Frank Zalom laboratory, UC Davis Department of Entomology and Nematology, create a fun-filled, innovative video, "I Wanna Be an Entomologist," a take-off of "I Wanna Be a Billionaire" from Travie McCoy's Lazarus album.
Heather entered her project in an Entomological Society of America (ESA) contest and won honorable mention.
In her video, she runs with an insect net, counts bugs in the Zalom lab, watches bees in a hive, and visits the Bohart Museum. At the Bohart, she hugs a display of butterflies and cradles a rose-haired tarantula and Madagascar hissing cockroach from its live "petting zoo."
"I wanna be an entomologist, so freakin' bad," Wilson sings. "I wanna be on the cover of Economic Entomology, smiling next to Frank and Jim Carey..."
"Frank and Jim" are Frank Zalom and James R. Carey, UC Davis distinguished professors in the Department of Entomology and Nematology. Zalom is a past president of the 7000-member ESA, and both were selected ESA Fellows.
Watch Heather Wilson's video at https://youtu.be/rwNbbJgXNXA and you'll probably decide being an entomologist sounds much more fun than being a billionaire. Who wants to be a billionaire, anyway? Let's go check out the insects!
The entomology line forms over there...don't crowd and don't cut in.
- Author: Kathy Keatley Garvey
Jay Rosenheim was a third-year physics major at the University of California, Davis, in 1981 when—“on a lark”--he enrolled in Professor Harry Kaya's Entomology 100 course.
The professor inspired him, the class enthralled him, and insects captivated him.
In mid-term, Jay changed his major to entomology, and went on to earn two degrees in entomology (bachelor's degree from UC Davis in 1983, and doctorate from UC Berkeley in 1987); join the UC Davis faculty in 1990; and become a UC Davis distinguished professor in 2018.
The former UC Davis physics major is now a newly inducted Fellow of the 7000-member Entomological Society of America (ESA), a global honor accorded to only 10 persons annually.
Marshall Johnson, a 2006 ESA Fellow and an emeritus Cooperative Extension specialist and researcher at UC Riverside, nominated Rosenheim for the award. “Jay was my postdoc at the University of Hawaii,” Johnson said. “He did a great job and I have kept my eye on his career ever since.
ESA singled out Rosenheim at its virtual meeting for his contributions on the ecology of insect parasitoids and predators, insect reproductive behavior, and the application of big data, or "ecoinformatics," methods in agricultural entomology.
And it all began four decades ago in a UC Davis classroom. This is what occurred.
“About a month or so before the course was to be taught, I received a call from this physics student, Jay Rosenheim, who wanted to take Entomology 100,” recalled Kaya, now an emeritus professor and himself an ESA Fellow (2007) for his international contributions to insect pathology and nematology. “I asked a few questions on why he wanted to take the course. He said he always loved insects but he said he did not have the prerequisites for the class--no college biology-- but he was keenly interested in insects and really wanted to take the class.”
Kaya was actually teaching the class for Professor Robbin Thorp (1933-2019), a bee specialist on sabbatical. “At the time, I had a 25 percent teaching appointment in entomology and a 75 percent research appointment in nematology,” Kaya said. “When Martin Birch, the department chair, asked me to teach the course, I told him that I hoped he could find someone else, but he came back and said I would be the best to teach it.” Birch assigned two of Thorp's graduate students, Evan Sugden and John Skinner, as teaching assistants for the twice-a-week entomology lab.
“Jay also worked briefly in my lab as an undergraduate as well,” Kaya related. “I should add other superlatives as outstanding and world-renowned entomologist. In my view, it did not matter who taught the ENT 100 course. Jay is simply an outstanding individual and has contributed so much on his own merit. Plus, he has a great personality.”
A native of Yorktown, N.Y, young Jay developed an interest in biology while exploring the vernal pools behind his Hudson River Valley home.
His insect interests not only led to his being elected an ESA Fellow but a Fellow of the American Association for the Advancement of Science; recipient of teaching awards from the Associated Students of UC Davis and the UC Davis Academic Senate; and the Distinguished Student Mentoring Award from ESA's Pacific Branch. He has authored more than 160 peer-reviewed publications, and mentored nearly 40 graduate students and postdoctoral researchers, now in the private sector, conservation nonprofits, journalism, or academia.
And it all began when a physics major named Jay Rosenheim asked to enroll in Professor Harry Kaya's entomology class.
- Author: Kathy Keatley Garvey
A member of the UC Davis faculty since 1980, Hammock received his doctorate in entomology and toxicology from UC Berkeley, where he studied insect science. He now devotes his research to human health.
What many people do not know, however, is that he began his career studying how caterpillars turn into butterflies.
That morphed into human health research.
“The work led to the discovery that many regulatory molecules are controlled as much by degradation and biosynthesis,” Hammock related. “The epoxy fatty acids control blood pressure, fibrosis, immunity, tissue growth, pain and inflammation to name a few processes.”
Fast forward to today.
An enzyme inhibitor developed in the Hammock lab and tested in mice by a team of international researchers shows promise that it could lead to a drug to prevent or reduce the disabilities associated with the neurodevelopmental disorders of autism and schizophrenia.
What the Inhibitor Did
"We discovered that soluble epoxide hydrolase (sEH) plays a key role in inflammation associated with neurodevelopmental disorders. Inhibiting that enzyme stops the inflammation and the development of autism-like and schizophrenia-like symptoms in animal models,” said collaborator Kenji Hashimoto, a professor with the Chiba University Center for Forensic Mental Health, Japan. The scientists found higher levels of sEH in a key region of the brain—the prefrontal cortex of juvenile offspring-- after maternal immune activation (MIA).
The news embargo lifted today (March 18) on their research, to appear in the Proceedings of the National Academy of Sciences (PNAS). (Link will be here: https://www.pnas.org/cgi/doi/10.1073/pnas.1819234116.) It's the work of 14 researchers from Chiba University Center for Forensic Mental Health; the Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, in Wako, Saitama, Japan; and the Hammock laboratory.
Reversed Cognitive and Sciatl Interaction Deficiencies
By inhibiting sEH, the researchers reversed cognitive and social interaction deficiencies in the mice pups. They hypothesize that this is due to increasing natural chemicals, which prevent brain inflammation. In people, this could reduce the disabilities associated with autism, such as anxiety, gastrointestinal disturbances and epilepsy.
Earlier studies have indicated a genetic disposition to the disorders. The team also studied postmortem brain samples from autism patients that confirmed the alterations.
“In the case of both autism and schizophrenia, the epidemiology suggests that both genetics and environment are contributing factors,” said neuroscientist and associate professor Amy Ramsey of the Department of Pharmacology and Toxicology, University of Toronto, who was not involved in the study. “In both cases, maternal infection is a risk factor that might tip the scales for a fetus with a genetic vulnerability. This study is important because it shows that their drug can effectively prevent some of the negative outcomes that occur with prenatal infections. While there are many studies that must be done to ensure its safe use in pregnant women, it could mitigate the neurological impacts of infection during pregnancy.”
Neuroscientist Lawrence David, professor and chair of the School of Public Health, University of Albany, N.Y., who was not involved in the research, said that the study might lead to “an important therapeutic intervention for neurodevelopment disorders.”
“There is increasing evidence that maternal immune activation activities (MIA) during fetal development can lead to aberrant neurobehaviors, including autistic-like activities,” said Lawrence, who studies neuroimmunology and immunotoxicology. The study “suggests that enzymatic control of fatty acid metabolism is implicated in neuroinflammation associated with schizophrenia and autism spectrum disorders. The expression of Ephx2 giving rise to soluble epoxide hydrolase (sEH) influences production of fatty acid metabolites, which elevate inflammation in the experimental model of mice after MIA; the sEH inhibitor TPPU (N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl)-urea) was postnatally used to improved behaviors. Analysis of cadaver brains from individuals with ASD also expressed increased sEH. Fatty acid metabolites have been known to affect fetal development, especially that of the brain; therefore, TPPU might be an important therapeutic intervention for neurodevelopmental disorders.”
Molecular bioscientist Isaac Pessah of the UC Davis School of Veterinary Medicine, distinguished professor and associate dean of research and graduate education in the Department of Molecular Biosciences, described the findings as “significant” and called for more detailed and expanded studies.
Autism: 1 of 68 Children
The Center for Disease Control and Prevention (CDC) estimates that 1 in 68 children in the United States have autism, commonly diagnosed around age 3. It is four times more common in boys than girls. CDC defines autism spectrum disorder as a “developmental disability that can cause significant social, communication and behavioral challenges.” The disorder impairs the ability to communicate and interact.
Schizophrenia: 1.2 Percent of Population
Approximately 3.5 million people or 1.2 percent of the population in the United States are diagnosed with schizophrenia, one of the leading causes of disability, according to the Schizophrenia and Related Disorders Alliance of America (SARDAA). Scores more go unreported. Approximately three-quarters of persons with schizophrenia develop the illness between 16 and 25 years of age. Statistics also show that between one-third and one half of all homeless adults have schizophrenia, and 50 percent of people diagnosed have received no treatment. Among the symptoms: delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, and obsessive-compulsive disorders, such as hoarding, according to SARDAA.
In their research paper, titled “Key Role of Soluble Epoxide Hydrolase in the Neurodevelopmental Disorders of Offspring After Maternal Immune Activation,” the scientists described sEH as “a promising prophylactic or therapeutic target for neurodevelopmental disorders in offspring after MIA.”
First author Min Ma and second Qian Ren of the Hashimoto lab conducted the animal and biochemical work, while chemists Jun Yang and Sung Hee Hwang of the Hammock lab performed the chemistry and analytical chemistry. Takeo Yoshikawa, a team leader with the RIKEN's Molecular Psychiatry Laboratory, performed measurements of gene expression in the neurospheres from iPSC (induced pluripotent stem cells) from schizophrenia patients and postmortem brain samples from autism patients.
Exciting and Productive
Hashimoto described the international collaboration as “exciting and productive.” This is their third PNAS paper in a series leading to endoplasmic reticulum stress. “We report discovery of a biochemical axis that leads to multiple neurological disorders, including depression, Parkinson's disease, schizophrenia, autism spectrum disorders and similar diseases,” he said.
William Schmidt, vice president of clinical development at EicOsis, a Davis-based company developing inhibitors to sEH to treat unmet medical needs in humans and companion animals, said the company is developing a first-in-class therapy for neuropathic and inflammatory pain. “EicOsis is in the process of finalizing our first human trials on the inhibitors of the soluble epoxide hydrolase, originally reported from UC Davis,” Schmidt said. “We are targeting the compounds as opioid replacements to treat peripheral neuropathic pain. It is exciting that the same compound series may be used to prevent or treat diseases of the central nervous system.”
Several grants from the National Institutes of Health, awarded to Hammock, supported the research. Hammock praised the many collaborators and students he has worked with on the project. “This work illustrates the value of research universities in bringing together the diverse talent needed to address complex problems,” Hammock said. “It also illustrates the value of fundamental science. This autism research can be traced directly to the fundamental question of how caterpillars turn into butterflies.”