- Author: Kathy Keatley Garvey
You don't usually see "honey bees" and "malaria" in the same sentence.
That won't be the case, though, when Joseph DeRisi, a Howard Hughes Medical Institute investigator and professor and vice chair of the Department of Biochemistry and Biophysics, University of California, San Francisco, comes to the UC Davis campus to lecture on Monday, Jan. 9.
His presentation, "A Seminar in Two Acts: Honey Bees and Malaria," is from 10 to 11 a.m. in the main auditorium (Room 2005) of the Genome and Biomedical Sciences Facility.
The seminar, open to all interested persons, is sponsored by the Biological Networks Focus Group of the Genome Center. Host is Oliver Fiehn, professor in the Department of Molecular and Cellular Biology and the Genome Center.
DeRisi, a molecular biologist and biochemist, was named the recipient of a MacArthur Foundation Grant (also known as "the genius award") in 2004. In 2008, DeRisi won the Heinz Award for Technology, the Economy and Employment. Among his many accomplishments: he designed and programmed a groundbreaking tool for finding (and fighting) viruses -- the ViroChip, a DNA microarray that test for the presence of all known viruses in one step.
The DeRisi lab drew international attention last year with publications in Public Library of Science journals.
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum (published in PLoS Biology, August 2011)
Temporal Analysis of the Honey Bee Microbiome Reveals Four Novel Viruses and Seasonal Prevalence of Known Viruses, Nosema, and Crithidia (published in PLoS One, June, 2011)
Among those working on the honey bee research and co-authoring the PLoS One paper was insect virus researcher Michelle Flenniken, a postdoctoral fellow in the Raul Andino lab at UC San Francisco and the recipient of the Häagen-Dazs Postdoctoral Fellowship in Honey Bee Biology at UC Davis.
Among DeRisi's collaborators on malaria research is UC Davis molecular biologist Shirley Luckhart, professor in the Department of Medical Microbiology and Immunology and an advisor in the Entomology Graduate Program.
DeRisi, who received his Ph.D. in biochemistry in 1999 from Stanford University, does amazing work.
He's a genius, to be sure.
Check out these links:
Joseph DeRisi Lab, UC San Francisco
Joe DeRisi: Biochemist (featured in TED ("Technology, Entertainment, Design" is a nonprofit devoted to Ideas Worth Spreading.)
Conversation with Joe DeRisi (New York Times)
Solving Medical Mysteries (YouTube)
Hunting the Next Killer Virus (YouTube)
Joseph DeRisi: Howard Hughes Medical Institute
Joseph DeRisi in Wikipedia
- Author: Kathy Keatley Garvey
Honey bees are still in trouble.
University of California scientists hammered home that point tonight during the PBS NewsHour program on the colony collapse disorder (CCD) and the declining bee population.
Extension apiculturist Eric Mussen of the UC Davis Department of Entomology told Spencer Michels of the PBS NewsHOur that "We really don't seem to have accomplished a whole lot (since CCD surfaced five years ago), because we're still losing, on an average, approximately 30 percent or more of our colonies each year. And that's higher than -- than it used to be. Only 25 percent of the beekeepers seem to have this CCD problem over and over and over. The other 75 percent have their fingers crossed and say, 'I don't know what this is, but it's not happening to me.'"
CCD is indeed frustrating, agreed Mussen, beekeeper-researcher Randy Oliver of Grass Valley, and UC San Francisco researchers Joseph DeRisi, Michelle Flenniken and Charles Runkel.
Flenniken, a postdoctoral fellow in the Raul Andino lab at UCSF and the recipient of the Häagen-Dazs Postdoctoral Fellowship in Honey Bee Biology at UC Davis, was among the team of scientists who recently discovered four new bee viruses, a discovery that may help unlock the secrets of why the bee population is declining.
The team found the new viruses while examining viruses and microbes in healthy commercially managed honey bee colonies over a 10-month period.
"Honey bee colonies, kind of like human populations, are exposed to a number of viruses and pathogens throughout the whole -- the entire course of the year," Flenniken told Michels. "So what this study provides us is a normal, healthy colony baseline of the ebb and flow of the microbes associated with that colony throughout the course of the year."
Oliver, who maintains 1000 hives and who has dealt with CCD, pointed out that CCD is resulting in "new science, new interest and new researchers" studying the mysterious malady.
As scientists delve in the mysteries of what's ailing the bees, they're bound to learn what's causing it. Meanwhile, it's good to see a national news program exploring this topic.
(Read PBS NewsHour transcript. Read more about the declining bee population on Spencer Michels' blog.)