- Author: Kathy Keatley Garvey
Monarchs and California golden poppies...Color them orange...Color them bold...Color them beautiful...
And color them natives...
The California golden poppy, Eschscholzia californica, California's state flower, is popping up all over, while monarchs, Danaus plexippus, are winging their way inland from their overwintering sites along the California coast.
The overwintering population in California dropped this year by 30 percent as compared to last year, according to the Xerces Society for Invertebrate Conservation. The stormy weather didn't help.
"The 27th annual Thanksgiving count ran from November 11 through December 3, 2023, totaling 233,394 butterflies across 256 overwintering sites in the western United States," Xerces reports on its website. "This tally is slightly lower than last year's (330,000), yet similar to the 2021 count. The overwintering population of western monarchs remains at approximately 5% of its size in the 1980s."
Overall, habitat loss and increased use of pesticides and herbicides continue to be key factors in the decline of the monarch population.
Interestingly enough, both monarchs and California golden poppies are toxic. "All parts of the (California golden poppy) plant have toxic properties if ingested," according to the State of California Capitol Museum website. And, as we all know, monarchs are toxic. As caterpillars, monarchs sequester or store toxins from milkweed, and those toxins help protect them from predators. The coloring is also a deterrent.
Two natives, toxic, but beautiful...
- Author: Kathy Keatley Garvey
EicOsis Human Health LLC, the Davis-based pharmaceutical company developing a non-narcotic drug to relieve chronic pain and inflammation, today announced the next step in its ongoing human clinical trials: the initiation of Phase 1b to test the safety of its drug candidate, EC5026.
The ongoing double-blind, placebo-controlled Phase 1b study is designed to investigate the safety and pharmacokinetics of daily doses of EC5026 over seven days.
EC5026, an inhibitor of the soluble hydrolase enzyme (sEH), was discovered and patented at EicOsis based on previous patents and research papers from the laboratory of UC Davis distinguished professor Bruce Hammock during his half-century of research.
“EC5026 plays a crucial role in regulating the metabolism of signaling lipids and responding to inflammation and other stress responses caused by trauma or disease,” said Hammock, who holds a joint appointment with the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. “We found sEH to be a target for treating pain, inflammation, cancer and other diseases.”
By inhibiting sEH, EC5026 alleviates pain by preventing the breakdown of natural analgesic and anti-inflammatory fatty acids. Preclinical studies demonstrate no sedation or other adverse behavioral effects and no signs of addiction.
“Many regulatory molecules are controlled as much by degradation as biosynthesis,” Hammock explained. "The epoxy fatty acids rapidly degraded by the sEH control blood pressure, fibrosis,immunity, tissue growth, depression, pain, and inflammation, to name a few processes.”
“The initial results from Cohort 1 appear to replicate the very favorable safety profile we observed in our previous two Phase 1a clinical studies where there were no adverse behavioral, cardiovascular, or neurological effects over five ascending single-dose levels,” said Dr. William Schmidt, EicOsis vice president of clinical development. “The maximum dose level was 5 to 10-fold higher than the anticipated analgesic dose in humans.”
“If Cohort 2 dosing also proceeds without clinically significant adverse effects and a favorable pharmacokinetic profile for once-a-day dosing,” Schmidt continued, “this provides encouragement for initiating our first analgesic efficacy study in the second quarter of 2024.”
EicOsis plans to initiate its first pain patient study in April 2024 “to evaluate safety and analgesic effects in patients with a spinal cord injury who have failed to achieve satisfactory pain relief with existing non-opioid chronic pain medications,” said Cindy McReynolds, EicOsis chief executive officer and former director of research.
“Initiation of the Phase 1b program represents a significant milestone for EicOsis Human Health and demonstrates the success and dedication of our team to make this happen,” said McReynolds, who holds a doctorate in pharmacology and toxicology from UC Davis. “Demonstrating safety in Phase 1b studies will allow us to evaluate efficacy in patients and bring forward safe and effective treatments for several serious diseases. For example, the sEH inhibitors are being considered for use for treatment of cancer in the UC Davis Comprehensive Cancer Center, and neurological disease through the UC Davis Health's designated Parkinson's Foundation Center of Excellence.”
“As a potential anti-inflammatory fatty acid, EC5026 holds promise in addressing neuroinflammation, a key factor in the manifestation and even progression of Parkinson's,” said Zhang, who holds both an M.D. and a PhD. “Ensuring its safety profile in healthy individuals is fundamental for establishing a foundation for further clinical trials. this investigation provides valuable insights into design and overall safety parameters, paving the way for the next stages in advancing this innovative therapeutic approach for Parkinson's disease."
The FDA granted Fast Track status to EC5026 in April 2020 to support the unmet medical need for safe and effective non-opioid analgesics. EicOsis clinical scientist Irene Cortés Puch, who authored the successful application, commented: “Both our commitment and focus at EicOsis Human Health are guided by a genuine concern for the well-being of patients and recognizing the importance of identifying effective pain management alternatives. Therefore, the initiation of this Phase 1b clinical trial is an exciting step in advancing our mission to provide safer and effective treatments.”
Hammock traces his research on chronic pain to his earlier work on how a caterpillar becomes a butterfly; a key enzyme, epoxide hydrolase, degrades a caterpillar's juvenile hormone, resulting in metamorphosis.
A member of the UC Davis faculty since 1980, Hammock founded ;EicOsis in 2011 and served as its chief executive officer until February 2023 when he transitioned to scientific officer and chairman of the board of directors. Highly honored by his peers, he is a member of the National Academy of Inventors and the National Academy of Sciences and received the 2020 Lifetime Achievement Award in Innovation from UC Davis Chancellor Gary May. Hammock has authored or co-authored more than 1400 peer-reviewed publications and holds more than 95 patents in agriculture, environmental science and medicinal chemistry.
EicOsis (pronounced eye-co-sis), derives its name from eicosanoids, “the major backbone of chemical mediators in the arachidonate cascade,” McReynolds said. “It symbolizes the epoxide group in chemistry, which is key to the anti-inflammatory chemical mediators and where the biochemical target called soluble epoxide hydrolase works.”
Approximately 50 million Americans (20 percent of the population) suffer from chronic pain, according to the Centers for Disease Control and Prevention. The annual economic toll is $560 billion, encompassing direct medical expenses, lost productivity, and disability claims.
More information on the Phase 1b multiple-ascending dose clinical study is available at https://clinicaltrials.gov/study/NCT06089837.
- Author: Kathy Keatley Garvey
They look at us, and we look back.
But if you're Larry Snyder of Davis, an insect photographer and a retired musician, you not only look back, but you take their images.
Snyder does just that when he observes the insects at the city-owned North Davis Channel, the site of a former monarch-milkweed research project organized and directed by UC Davis professor Louie Yang. The site is also known as "the Covell drainage channel."
And now Snyder is sharing many of his images in a photography exhibit, "Insects at the Ditch," which opened Jan. 6 and continues through Feb. 2 at Logos Books, 513 2nd St., Davis.
The UC Davis research project began in December 2013 when Yang, a community ecologist, and his team planted narrow-leaved Asclepias fascicularis, at the site. Then they monitored the interactions of the monarchs, Danaus plexippus, on the plants from 2015 through 2017, culminating in the July 2022 publication of "Different Factors Limit Early-and Late-Season Windows of Opportunity for Monarch Development," in the journal Ecology and Evolution.
"I began watching, and then photographing, the insect life on the plants," Snyder related, adding that he became especially interested in insect behavior and interaction.
"It's my adopted back yard."
"I am grateful to the Bohart Museum of Entomology and its remarkable staff and associates for the frequent assistance in identification and understanding of life in the insect world." He has also shared his images with the Bohart Museum.
He directed the opera from 1976 to 2000. He also published a book, German Poetry in Song, in 1995. In 2001 he chaired the organizing committee for The Davis Star Show astronomy festival.
Snyder's last photography show (of 5x7 black and white contact prints) was at the old Davis Art Center in 1985. He recalls using a "5x7 Deardorff, one of those things resembling an accordion on stilts, rather unsuited for living macro subjects, and which I sold 25 years ago."
As the late E. O. Wilson said: "It's the little things that run the world."
(Editor's Note: The Bohart Museum, home of a global collection of eight million insects, is located in Room 1123 of the Academic Surge Building, 455 Crocker Lane, UC Davis. The Bohart Museum's next open house, themed "Social Wasps," is from 1 to 4 p.m., Saturday, Jan. 20. It is free and family friendly. UC Davis distinguished professor Lynn Kimsey, director of the Bohart, will share her wasp expertise.)
- Author: Kathy Keatley Garvey
Can a praying mantis catch a monarch?
Yes, it can. And yes, it does.
It was Sept. 14, 2013. As I approached a Vacaville supermarket, I noticed pink lantana blooming furiously near the entrance, and then, a familiar-looking butterfly quietly sipping nectar.
"Ah, there's a monarch," I observed.
I wasn't the only one watching the monarch.
A female praying mantis, Stagmomantis limbata, was watching it, too.
In a nano-second, it was all over.
A meal for the mantis.
One less monarch to migrate.
Yes, it can. And yes, it does.
- Author: Kathy Keatley Garvey
No, say many scientists, including Hugh Dingle, professor emeritus of entomology, behavior and evolution at UC Davis.
Professor Dingle is an internationally known expert on animal migration. He's researched animal migration for some 50 years. In the last 20 years or so, he has focused on monarch butterflies. He has authored two editions of Migration: The Biology of Life on the Move and some 100 papers. National Geographic featured Professor Dingle in its cover story on “Great Migrations” in November 2010. LiveScience interviewed him for its November 2010 piece on “Why Do Animals Migrate?” (See news story that includes his biographical information)
Professor Dingle, a resident of Marin County, responded to a recent front-page article in a Marin County paper about the California ban on tropical milkweed. Banning tropical milkweed, A. curassavica, will NOT save the monarch, Dingle emailed the reporter. In fact, he said, the ban will "essentially have zero effect on monarchs" and "no one should rush out and pull out their tropical milkweed as it would be a waste of time and effort. Nurseries should also be able to continue to sell it."
The professor shared this with Bug Squad:
- "There is not enough tropical milkweed planted to have much influence (see the amount of A. syriaca and A. fascicularis throughout the American West not to mention various other species like A. erosa, cordifolia, californica, etc.) Yes, there are parasites on A. curassavica as there are on ALL milkweeds."
- "There are populations of monarchs that are doing just fine feeding exclusively on A. curassavica (e.g. on many Pacific Islands, such as Guam where I have studied them."
- "Migration and the diapause that accompanies it in the fall are determined by shortening photoperiod and temperature (warm temps can override short days hence the issue with climate change). There is no significant influence of food plant."
Tropical milkweed has been in California for more than a century. It's along our roadsides, in our parks, in our gardens. If the California border were moved a bit, it would be a native plant. Yet the California Department of Food and Agriculture, influenced by native plant proponents, has deemed it a "noxious weed."
Professor Dingle is among many scientists who point out that milkWEED (despite the "weed" in its name), is NOT a noxious plant. If you're standing on the California-Mexico border, on one side it's a noxious weed (evil, dangerous, nasty, get-rid-of-it-now, how-dare-you) and inches away, it's a beautiful host plant for monarchs, and a great nectar source for monarchs and other pollinators, including honey bees, syrphid flies and hummingbirds.
The California Department of Fish and Wildlife's ban on rearing monarchs (no one can do so without a permit) is unsettling to many. Entomologist Jeff Smith, who curates the Lepidoptera collection at the Bohart Museum of Entomology at UC Davis and is a member of the Lepidopterists' Society, reared a few monarchs as a child, but laments that today, no one in California can do so without a permit, and it's difficult to get a permit unless you're a researcher.
In the latest edition of the Lepidopterists' Society newsletter, Robert Michael Pyle (founder of the Xerces Society for Invertebrate Conservation) and David Wagner wrote a piece, "Keep Nets in the Hands of Kids--and Others!"
An excerpt: "Give a kid a net, and watch her go! Not that the net is the only porthole into our world. For some it could be raising caterpillars or tadpoles, keeping mantises and walking sticks as pets, or examining ants, beetles, and grass- hoppers through a magnifying glass. But the common feature is having hands-on, unfettered exploration of the living world as children. Many life-science professionals, including RMP's cardiologist, ascribe their passion for life and nature to hunting bugs, crawdads, and pollywogs in their youth. This is why the Society instituted the Outernet Project, to get nets into the hands of children—a task made more difficult not only by the umbilical USB connection now present at birth and children's subsequent inseparability from electronica, but also by the loss of BioQuip. Is the coup de grâce for children's face-to-face fascination with small-scale life to be delivered now by well-intended but ill-considered regulation?"
So Very Controversial. Amazing that tropical milkweed issue has become so very controversial. You cannot post an image of a egg, caterpillar, chrysalis or a monarch on A. curassavica--a food and nectar source--without a native plant proponent attacking you and ordering you to remove that tropical plant in your garden immediately. (Never mind that you are growing native milkweed as well.) One scientist told me: "They just want to control you and bully you."
In our pollinator garden in Vacaville, monarchs prefer tropical milkweed over the non-natives. Tropical is more toxic.
Mona Miller, who administers the popular Facebook page, Creating Habitat For Butterflies, Moths, & Pollinators, related: "Monarch are resilient insects, they have so many strategies to increase their population, but they do have their limits. We must stop pulling out tropical milkweed and cutting it back. Washing off all milkweed should suffice to clean off the OE spores. I emailed several scientists, no one could tell me that OE (Ophryocystis elektroscirrha is a protozoan parasite) has any way to attach to milkweed leaves other than getting caught in the hairs. Tropical milkweed has smooth leaves. Tropical milkweed has been in California since 1909, that is over 100 years. Totally eradicating tropical milkweed, just like totally eradicating all the eucalyptus trees (non-natives), would have a detrimental effect on the monarch population--perhaps it already has."
Indeed, folks should pay more attention to habitat loss and pesticide use, the real culprits of the monarch population decline.
Bohart Museum Open House. At any rate, be sure to attend the Bohart Museum of Entomology's open house on monarchs from 1 to 4 p.m., Saturday, Nov. 4 in Room 1124 of the Academic Surge Building, 455 Crocker Lane, UC Davis. It's free and family friendly. A number of scientists will be there to answer your questions.
Scheduled to participate are:
- UC Davis distinguished professor emeritus Art Shapiro of the Department of Evolution and Ecology, who has studied butterfly populations in central California since 1972 and maintains a research website, Art's Butterfly World.
- UC Davis emeritus professor Hugh Dingle, a worldwide authority on animal migration, including monarchs. He is the author of Migration: The Biology of Life on the Move (Oxford University Press), a sequel to the first edition published in 1996. See news story on the UC Davis Entomology and Nematology website.
- UC Davis professor Louie Yang, who does research on monarchs. Due to parental duties, he may be able to attend only the last part of the open house. See news story about his work.
- UC Davis professor Elizabeth Crone of the Department of Evolution and Ecology, formerly of Tufts University, who researches monarchs. See news story about the declining monarch population on the UC Davis Entomology and Nematology website.
The Bohart Museum houses a global collection of eight million insect specimens, plus a living insect petting zoo (Madagascar hissing cockroaches and stick insects, among others), and a insect-themed gift shop. UC Davis distinguished professor Lynn Kimsey has directed the Bohart Museum, founded in 1946, since 1990.