Dr. Panigrahy is an assistant professor of pathology, Beth Israel Deaconess Medical Center, Harvard Medical School.
His topic is "Pro-Resolution Lipid Mediators in the Resolution of Cancer," said Hammock, who holds a joint appointment with the UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center.
The abstract: "For decades, cancer therapy has focused on killing cancer cells, from broad cytotoxic therapy to the inhibition of specific molecular pathways. However, cytotoxic cancer therapy may inherently be a double-edged sword as apoptotic tumor cells ('debris') may stimulate inflammation and tumor growth via a pro-inflammatory ‘cytokine storm'. Environmental carcinogens (e.g. Aflatoxin B1) can also generate debris which may stimulate inflammation and tumor dormancy escape. This is clinically relevant as 30-90% of humans harbor dormant tumors."
"To stimulate the natural debris-clearing process which would eliminate this source of tumor stimulation, we utilized endogenous specialized pro-resolving mediators (SPMs), specifically maresins, which are biosynthesized by human macrophages from endogenous docosahexaenoic acid. Additionally, novel COX-2/sEH inhibitors (e.g. PTUPB) can stimulate inflammation resolution more potently than either COX-2 or sEH inhibition alone by stabilizing epoxy-eicosanoids, promoting the formation of pro-resolving mediators such as lipoxins, and activating anti- inflammatory cytokine programs. In dramatic contrast to conventional anti-inflammatories, pro-resolving lipid mediators clear debris and counter-regulate a series of pro-inflammatory cytokines. We demonstrate that the resolution of inflammation represents a novel modality in cancer treatment by enhancing endogenous clearance of tumor cell debris and counter- regulating pro-tumorigenic cytokines."
Earlier this year, a collaborative research paper authored by Hammock, Panigrahy and colleagues won the Editor's Pick of the Journal of Investigation for the month of July. The paper, “Preoperative Stimulation of Resolution and Inflammation Blockade Eradicates Micrometastases,” relates how blocking inflammation and/or activating the resolution of inflamation before surgery can eradicate small tumors and promote long-term survival in experimental cancer modes. (See news story.)
Dipak was accepted into medical school at Boston University at age 17. He trained in surgery with Dr. Roger Jenkins, who performed the first liver transplant in New England. Over the past decade, Dr. Panigrahy led angiogenesis and cancer animal modeling in the Judah Folkman laboratory. He joined the Beth Israel Deaconess Medical Center in 2013, and in 2014 was appointed assistant professor of pathology and currently has a laboratory in the Center for Vascular Biology Research.
For more information on the seminar, contact Hammock Lab account manager Gregory Zebouni at firstname.lastname@example.org or (530) 752-8465.
Leal, a distinguished professor in the Department of Molecular and Cellular Biology and a former chair of the Department of Entomology (now the Department of Entomology and Nematology) is one of 168 distinguished academic inventors who will be inducted April 10 at NAI's ninth annual meeting in Phoenix. The only other UC Davis recipient: Cristina Davis, the Warren and Leta Geidt Endowed Professor and Chair, Department of Mechanical and Aerospace Engineering
“I am humbled by this honor,” said Leal, who was nominated by UC Davis chancellor emerita Linda Katehi, an NIA fellow inducted in 2012. “To express my sentiment I have to paraphrase my predecessor as president of the International Society of Chemical Ecology, late Professor Thomas Hartmann, who said in our meeting in Prague in 1996: ‘In academia, students, postdocs, and other associates do most of the work and professors received the honors.' I look forward to opportunities to support NAI's mission of promoting innovation and celebrating invention.”
Katehi, now of Texas A&M, where she is a distinguished TEES (Engineering Experiment Station) chair and professor, Department of Electrical and Computer Engineering, praised Leal's “novel, sustainable and continued contributions to the field of entomology and for their greater implications in molecular and cellular biology and the understanding of disease and prevention.” Leal holds 28 Japanese and two U.S. patents.
Leal is the second faculty member affiliated with the Department of Entomology to be selected an NIA fellow. Distinguished professor Bruce Hammock, who holds a joint appointment with the Department of Entomology and the UC Davis Comprehensive Cancer Center, received the honor in 2014. (See news story.)
Said Hammock: “When Walter Leal reached UC Davis, he came with the reputation of being a 'one man army in research.' This reputation was well deserved. I know of no one at UC Davis who matches Walter in taking his remarkable fundamental advances in science and translating them to increase the safety and magnitude of world food production.”
Leal, an expert in insect communication investigates how insects detect odors, connect and communicate within their species; and detect host and non-host plant matter. His research, spanning three decades, targets insects that carry mosquito-borne diseases as well as agricultural pests that damage and destroy crops. He and his lab drew international attention with their discovery of the mode of action of DEET, the gold standard of insect repellents. (See the Leal lab's work on DEET in Entomology Today.)
He and his collaborators, including Nobel Laureate Dr. Kurth Wuthrich (Chemistry 2002), unravel how pheromones are carried by pheromone-binding proteins, precisely delivered to odorant receptors, and finally activated by pheromone-degrading enzymes.
That led to Leal's identification of the sex pheromones of the navel orangeworm (Amyelois transitella), a pest of almonds, figs, pomegranates and walnuts, the major hosts. This has led to practical applications of pest management techniques in the fields.
Leal, a fellow of the Entomological Society of America (ESA), "has greatly advanced scientific understanding of insect olfaction," said Joe Rominiecki, communications manager, Entomological Society of America. "He has identified and synthesized several insect pheromones, and his collaborative efforts led to the first structure of an insect pheromone-binding protein."
'Tangible Impact on Quality of Life'
“The NAI Fellows Program highlights academic inventors who have demonstrated a spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development and the welfare of society,” said NIA director Jayde Stewart. “Election to NAI Fellow is the highest professional distinction accorded solely to academic inventors. To date, NAI Fellows hold more than 41,500 issued U.S. patents, which have generated over 11,000 licensed technologies and companies, and created more than 36 million jobs. In addition, over $1.6 trillion in revenue has been generated based on NAI Fellow discoveries.”
A native of Brazil, educated in Brazil and Japan, and fluent in Portuguese, Japanese and English, Leal received his master's degree and doctorate in Japan: his master's degree at Mie University in 1987, and his doctorate in applied biochemistry at Tsukuba University in 1990. Leal then conducted research for 10 years at Japan's National Institute of Sericultural and Entomological Science and the Japan Science and Technology Agency before joining the faculty of the UC Davis Department of Entomology in 2000. He served as chair of the department from July 2006 to February 2008.
Leal co-chaired the 2016 International Congress of Entomology meeting, "Entomology Without Borders," in Orlando, Fla., that drew the largest delegation of scientists and experts in the history of the discipline: 6682 attendees from 102 countries.
Leal served as president of the International Society of Chemical Ecology and ESA's Integrative Physiological and Molecular Insect System Section. He co-founded the Asia Pacific Association of Chemical Ecologists and played a key role in founding the Latin American Association of Chemical Ecology.
Among his many other honors, Leal is a fellow of the American Association for the Advancement of Science and the California Academy of Sciences; an honorary fellow of the Royal Entomological Society and an inductee of the Brazilian Academy of Sciences. He received a silver medal from the International Society of Chemical Ecology. Leal recently presented the Founders' Memorial Lecture at the ESA meeting in St. Louis, the first UC Davis scientist selected to do so.
“Walter is an amazing person and an amazing scientist,” said Fred Gould, distinguished professor in the Department of Entomology and Plant Pathology at North Carolina State University. “His work has opened new doors to the understanding of how insects receive and perceive odors and has saved farmers in California and Brazil more than $100 million. He's at a point where he could sit back and bask in the glory of his accomplishments, but that is not Walter. He remains as prolific as ever.”
Born Oct. 14, 1959 in Madison, Wisc., he was one of the pioneering scientists researching the newly discovered thousand cankers disease (TCD), caused by the walnut twig beetle, Pityophthorus juglandis, in association with the canker-producing fungus, Geosmithia morbida. He was a worldwide authority on the insect, fungus and disease. (See obituary in Davis Enterprise)
He received his doctorate in forest entomology at UC Berkeley where he specialized in pine bark beetles. He completed postdoctoral work at the University of Nevada-Reno and was on the faculty of the University of Minnesota-St. Paul for several years before returning to California in 2002. He was an accomplished musician, playing the clarinet.
In his memory, he was honored with a moment of silence this week at the Entomological Society of America meeting in St. Louis, Mo.
The tributes are pouring in:
Nematologist Steve Nadler, professor and chair of the UC Davis Department of Entomology and Nematology: "Steve was an excellent chemical ecologist whose research on insect pests of trees proved to be of great importance to landscapes throughout North America.”
Chemical ecologist Walter Leal, UC Davis Department of Molecular and Cellular Biology and past chair of the UC Davis Department of Entomology (now the Department of Entomology and Nematology). "Chemical ecology lost a champion, forestry entomology lost an ally, and we will miss a friend and colleague. Steve served the International Society of Chemical Ecology as Councilor, the Journal of Chemical Ecology as Associate Editor, and mentored many undergraduate and graduate students and postdoctoral scholars. He elucidated biochemical mechanisms related to bark beetle pheromones, leaving behind a legacy of papers and review articles, some of which have already been cited almost one thousand times. I copied from him the style of praising colleagues when citing their good work by adding the advert 'elegantly' like in the following sentence. Steve Seybold elegantly demonstrated how bark beetles make their pheromones."
Doctoral student Jackson Audley of the Seybold lab: "Steve Seybold was a brilliant scientist and an integral component of the forest entomology community, especially here in the western USA. I admired the amount of time he spent out in the field. I have often heard it said that once a field biologist obtains a Ph.D., that they often become something of an 'armchair biologist', not Steve. I have never seen him happier than when he was out on long field excursions, hunting down various trees and tree pests. I hope to emulate that characteristic in my own career. Although my time working with Steve now feels cut abruptly and unfairly short, he imparted a great deal of wisdom upon me in that time. I am incredibly grateful to have had Steve as a mentor and a friend. He contributed a great deal to making me into the scientist I am today. He will be sorely missed."
Seybold lab alumnus Andrew Graves (now a zone leader entomologist with the Forest Service, Forest Health Protection, New Mexico Zone): "We are all shocked and saddened. Steve and I worked together for nearly 20 years. A faithful mentor, constant teacher, an incessant researcher to whom the time of day or length of time were meaningless, a good friend who contributed much to our world. A too early passing and a great loss for us all. He was a good man and will be missed by many. If I had to guess, he would've been disappointed he didn't finish that last manuscript."
Seybold lab alumnus Stacy Hishinuma, who went on to accept a position in the Pacific Southwest Region, San Bernardino: "Steve was a pivotal person in my life. I worked with him for more than 10 years and during that time he pushed me to have the highest scientific standards and taught me all I know about research. He was an involved mentor and cared deeply about the success of his students. His love was expressed through the red marks on our manuscripts, the time he spent helping us with presentations, and the pop quizzes on insect identification. When I started graduate school, people advised me to be the first person in and the last person to leave. This was impossible in the Seybold lab since Steve regularly started working before dawn. It was somehow always startling when I would email Steve at 4:00a, before heading to sleep, and he would immediately respond. Steve's work ethic was unprecedented. It was inspiring to see his passion for research. His love for science was only rivaled by his love for his daughters. I'll always miss the conversations we had driving to field sites, eating at his go-to restaurants, and geeking out about bark beetles. Thank you for everything Steve. I hope I can help carry on your legacy through my own work as a forest entomologist."
Steve is survived by his widow, Julie Tillman, and daughters Natalie Ann, 11, and Emily Jane, 17. He was preceded in death by his father, Robert. Other survivors include his mother, Patricia; brothers Russel and Richard (Julie).
"Steve loved his work and his daughters with his whole self and heart," Julie said. "He will be sorely missed by his family and friends, his lab family and his huge network of professional colleagues."
A visitation will be held from 5 to 7 p.m. Friday, Nov. 22, at Smith Funeral Home in Davis. A service will be held on Saturday, Nov. 23, at Saint James Church in Davis at 10 a.m. with interment at a later date near his father at Forest Hill Cemetery in Madison. Memorials in his name may be made to the American Heart Association, National Parks Conservation Association or the Entomology and Nematology Student Support fund at UC Davis.
The Linnaean Games, launched in 1983, are lively question-and-answer, college bowl-style competitions on entomological facts and played by winners of the ESA branch competitions. The teams score points by correctly answering random questions.
This year's UC team, captained by Ralph Washington Jr., a UC Berkeley public policy graduate student who received his bachelor's degree in entomology at UC Davis, includes five UC Davis doctoral students in entomology: Brendon Boudinot, Zachary Griebenow and Jill Oberski, all of the Phil Ward lab, UC Davis Department of Entomology and Nematology; and alternates Miles Dakin of the Christian Nansen lab and Hanna Kahl of the Jay Rosenheim lab.
Washington has captained all three winning teams, and Boudinot has helped anchor all of them.
- 2018: UC won the national championship (link to news story) in Vancouver, B.C., defeating Texas A&M Graduates, with Washington captaining the team and joined by Boudinot, Oberski and Griebenow, and Emily Bick (who received her doctorate this year) of the Christian Nansen lab. (No video of the championship round)
- 2017: The UC team did not compete. (Texas A&M won the national championship; see championship round on YouTube)
- 2016: UC won the national and international championships at the University of Florida, at the joint and international meeting of ESA and the International Congress of Entomology (ICE), defeating the University of Georgia. (See championship round on YouTube)
- 2015: UC won the national championship at the games held in Minneapolis, Minn., defeating the University of Florida. (See championship round on YouTube)
All branches of ESA conduct a Linnaean Games competition, with each branch sending the winner and the second-place winner to the nationals. The UC team has won the Pacific Branch (PBESA) competition multiple times. PBESA encompasses 11 Western U.S. states, plus several U.S. territories and parts of Canada and Mexico.
Some of the previous questions asked of the UC team during the championship rounds:
Toss-Up Question: What is the smallest insect that is not a parasite or parasitoid?
Answer: Beetles in the family Ptiliidae.
Bonus Question:Some species of mosquitoes lay eggs that can undergo diapause or aestivation. Give at least three cues that trigger the aquatic eggs to hatch.
Answer: Temperature, immersion in water, concentration of ions or dissolved solutes.
Toss-Up Question: Chikungunya is an emerging vector-borne disease in the Americas. Chikungunya is derived from the African Language Makonde. What means Chikungunya in Makonde?
Answer: Bending up.
Toss-Up Question: A Gilson's gland can be found in what insect order?
Toss-Up Question: Certain Chrysomelid larvae carry their feces as a defensive shield. To what subfamily do these beetles belong?
Bonus Question: The first lepidopteran sex pheromone identified was bombykol. What was the first dipteran sex pheromone identified? Give the trade or chemical name.
Answer: Muscalure, Z-9-Tricosene. It is also one of the chemicals released by bees during the waggle dance.
Toss-Up Question: What famous recessive gene was the first sex-linked mutation demonstrated in Drosophila by T.H. Morgan?
Bonus Question: Cecidomyiidae are known as the gall flies. What is unique about the species Mayetiola destructor, and what is its common name?
Answer: Mayetiola destructor is the Hessian Fly, a tremendous pest of wheat. It does not form galls.
Toss-Up Question: Nicrophorus americanus is listed under what legislative act?
Answer: The Endangered Species Act
Toss-Up Question: In what insect order would you find hemelytra?
Answer: The order Hemiptera.
Toss-Up Question: The subimago stage is characteristic of what insect order?
Answer: The order Ephemeroptera
Bonus Question: A 2006 Science article by Glenner et al. on the origin of insects summarized evidence that Hexapods are nothing more than land-dwelling crustaceans, which is to say that the former group Crustacea is paraphyletic with respect to the Hexapoda. What hierarchical name has been used to refer to this clade?
Toss-Up Question: What are the three primary conditions that define eusociality?
Answer: Cooperative brood care, overlapping generations, and reproductive division of labor
In addition to serving on the Linnaean Games Team, Boudinot will be honored as the PBESA recipient of the John Henry Comstock Award, the top graduate student award. PBESA is one of six branches of the ESA.
Founded in 1889, ESA is the world's largest organization serving the professional and scientific needs of entomologists and individuals in related disciplines. It is comprised of more than 7000 members, who are affiliated with educational institutions, health agencies, private industry, and government. Members are researchers, teachers, extension service personnel, administrators, marketing representatives, research technicians, consultants, students, pest management professionals, and hobbyists.
His talk, free and open to the public, is sponsored by the UC Davis Emeriti Association and the UC Davis Retirees' Association.
“Honey bees exhibit complex social behavior that rivals our own,” Page says. “It is fundamentally bound within a social contract much like ours that makes the basic social structure inescapable, a consequence of living together in family groups. Social structures evolve by natural selection operating on the final product, the colony as a reproductive unit. The structures themselves are reverse engineered.”
“I will show how selection on the economy of the colony shapes structures from nest and social architecture to gene networks.”
Page is a UC Davis Distinguished Emeritus Professor, an honor awarded in January; and a Regents Professor Emeritus and University Provost Emeritus from Arizona State University, Tempe. He retired from UC Davis in May 2004 after chairing the Department of Entomology, now the Department of Entomology and Nematology.
Born and reared in Bakersfield, Kern County, Rob received his bachelor's degree in entomology, with a minor in chemistry, from San Jose State University in 1976. After obtaining his doctorate from UC Davis in 1980, he served as assistant professor at The Ohio State University before joining the UC Davis entomology faculty in 1989 as an associate professor. He began working closely with Harry H. Laidlaw Jr., (the father of honey bee genetics) for whom the university's bee facility is named. Together they published many significant research papers.
Page chaired the Department of Entomology from 1999 to 2004, when Arizona State University recruited him to be the founding director of the School of Life Sciences of Arizona State University (ASU). His ASU career advanced to dean of Life Sciences; vice provost and dean of the College of Liberal Arts and Sciences; and university provost.
Page is known for his research on honey bee behavior and population genetics, particularly the evolution of complex social behavior. One of his most salient contributions to science was to construct the first genomic map of the honey bee, which sparked a variety of pioneering contributions not only to insect biology but to genetics at large.
At UC Davis, he maintained a honey bee-breeding program for 24 years, from 1989 to 2015, managed by bee breeder-geneticist Kim Fondrk at the Harry H. Laidlaw Jr. Honey Bee Research Facility. They discovered a link between social behavior and maternal traits in bees. Their work was featured in a cover story in the journal Nature. In all, Nature featured his work on four covers from work mostly done at UC Davis.
Page and his lab pioneered the use of modern techniques to study the genetic basis of social behavior evolution in honey bees and other social insects. He was the first to employ molecular markers to study polyandry and patterns of sperm use in honey bees. He provided the first quantitative demonstration of low genetic relatedness in a highly eusocial species.
His work has garnered a significant impact in the scientific community through his research on the evolutionary genetics and social behavior of honey bees. He was the first to demonstrate that a significant amount of observed behavioral variation among honey bee workers is due to genotypic variation. In the 1990s, he and his students and colleagues isolated, characterized and validated the complementary sex determination gene of the honey bee; considered the most important paper yet published about the genetics of Hymenoptera. The journal Cell featured their work on its cover. In subsequent studies, he and his team published further research into the regulation of honey bee foraging, defensive and alarm behavior.
Page has authored than 250 research papers, including five books: among them “The Spirit of the Hive: The Mechanisms of Social Evolution,” published by Harvard University Press in 2013. He is a highly cited author on such topics as Africanized bees, genetics and evolution of social organization, sex determination, and division of labor in insect societies. His resume shows more than 18,000 citations.
Highly honored by his peers, Page is a fellow of a number of organizations, including the American Association for the Advancement of Science, the California Academy of Sciences, the Entomological Society of America, and organizations in Germany and Brazil. He received the Alexander von Humboldt Senior Scientist Award, known at the Humboldt Prize, the highest honor given by the German government to foreign scientists. He received the 2018 Thomas and Nina Leigh Distinguished Alumni Award from UC Davis Department of Entomology and Nematology.
The UC Davis Retiree Center periodically holds noon educational seminars ("BrainFood Talks") featuring timely speakers. For more information, contact the UC Davis Retiree Center at (530) 752-5182 or email@example.com.