- Author: Kathy Keatley Garvey
Makedonka Mitreva, professor of medicine and genetics, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, will speak on "Multi-omics Applications in Helminth Research" at her seminar set for 4:10 p.m., Pacific Time. The Zoom link:
https://ucdavis.zoom.us/j/99515291076.
"My research takes advantage of next-generation genomic and computational approaches to empower the study of infectious diseases, with a focus on neglected tropical diseases caused by helminths," Mitreva writes in her abstract. "Overcoming the main obstacle related to scarce understanding of molecular mechanisms involved in host invasion and pathogenesis, required generating comprehensive omics datasets from various helminth species. Interrogating such multi-omics data followed by systems biology approaches provided us with opportunity to greatly advance translational helminth research."
On her website, Mitreva points out: "More than 3 billion people worldwide live on less than $2.50 a day. The majority live in low- and middle- income countries, and some in vulnerable communities of high-income countries. Chronic infections in these populations are predominated by parasitic helminths. Helminth infections are typified by long term chronicity accompanied with various symptoms (pain, malnutrition, physical disabilities, rectal prolapse, deformity), cause growth impairment in children, anemia, adverse outcomes in pregnant women and reduced productivity in adults, which all conspire to promote and maintain poverty."
She recently joined the editorial board of Frontiers in Parasitology as section chief editor.
Mitreva says her lab "uses systems biology approaches to provide fundamental molecular information for these parasitic infections of importance to global health. The acquired knowledge accelerates both basic and translational research and provides practical results for global health improvement." Her lab's broad interest in global health improvement, she points out, is reflected in many other collaborative projects, including malaria, tuberculosis and medical metagenomics.
Mitreva holds bachelor and master's degrees in biology, 1990 and 1994, respectively, from Saints Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia. She received her doctorate in plant sciences, molecular and population genetics in 2001 from the Wageningen University and Research Centre, Wageningen, The Netherlands Laboratory of Nematology.
For any technical issues encountered with the virtual seminar, reach coordinator Shahid Siddique at ssiddique@ucdavis.edu.
- Author: Kathy Keatley Garvey
Coordinator Shahid Siddique, assistant professor of nematology, UC Davis Dpartment of Entomology and Nematology, has announced the list of spring quarter seminars.
The seminars will take place at 4:10 p.m., Pacific Time, on Wednesdays, beginning March 30 and will continue through June 1. The in-person seminars will be in 122 Briggs Hall. All also will be broadcast on Zoom. The link:
https://ucdavis.zoom.us/j/99515291076.
Wednesday, March 30 (in-person and virtual)
Ziad Khouri, international graduate student
Bohart Museum of Entomology, UC Davis Department of Entomology and Nematology
Title: "Scoliid Wasp Evolution and Some Adventures with Posterior Predictive Simulation"
Host: Lynn Kimsey, director of the Bohart Museum of Entomology and UC Davis distinguished professor of entomology
Wednesday, April 6 (virtual)
Makedonka Mitreva, professor of medicine and genetics
Washington University School of Medicine, St. Louis
Title: "Multi-omics Applications in Helminth Research"
Host: Shahid Siddique, assistant professor, UC Davis Department of Entomology and Nematology
Wednesday, April 13 (in-person and virtual)
Tobin Hammer, assistant professor, ecology and evolutionary biology
UC Irvine
Title: “Mystery of the Missing Microbes: Why Do Bees Keep Losing Their Symbionts?”
Host: Rachel Vannette, associate professor, UC Davis Department of Entomology and Nematology
Wednesday, April 20 (in-person and virtual)
Jared Ali, assistant professor of entomology
Pennsylvania State University, State College
Title: "Chemical Ecology of Plant Defense and Multi-trophic Interactions: Bad Bugs, Pungent Parasites and Toxic Travelers"
Host: Richard Karban, professor, UC Davis Department of Entomology and Nematology
Wednesday, April 27 (virtual)
Heather Bruce, postdoctoral researcher
Marine Biological Laboratory, University of California, Berkeley
Title: "Evolution and Development of Arthropod Appendages: Novelty and Homology"
Host: Xavier Zahnle, doctoral student, Jason Bond lab, UC Davis Department of Entomology and Nematology
Wednesday, May 4 (virtual)
Scott McArt, assistant professor of entomology
Cornell University, Ithaca, N.Y.
Title: "Pesticide Risk to Pollinators: What We Know and What We Need to Know Better"
Host: Lexie Nichole Martin, doctoral student, Rachel Vannette lab, UC Davis Department of Entomology and Nematology
Wednesday, May 11 (virtual)
Mostafa Zamanian, assistant professor, Department of Pathobiological Sciences
School of Veterinary Medicine, University of Wisconsin, Madison
Title: "Combing Target and Whole-Organism Paradigms for Anthelmintic Discovery"
Host: Shahid Siddique, assistant professor, UC Davis Department of Entomology and Nematology
Wednesday, May 18 (virtual)
Corlett Wood, assistant professor of biology
University of Pennsylvania, Philadelphia
Title: "The Conflict Beneath your Feet: Indirect Effects in Plant-Symbiont Interactions"
Host: Shahid Siddique, assistant professor, UC Davis Department of Entomology and Nematology
Wednesday, May 25 (in-person and virtual)
James R. Carey, UC Davis distinguished professor
UC Davis Department of Entomology and Nematology
Title: "The Conceptual Sweep of a Mathematical Discovery in Insect Demography: From Estimation of Medfly Population Age Structure to an Historical Analysis of U.S. Congress Incumbency Distributions, 1785-2000”
Host: Shahid Siddique, assistant professor, UC Davis Department of Entomology and Nematology
Wednesday, June 1 (in-person and virtual)
Isgouhi Kaloshian, Divisional Dean, Agricultural and Natural Resources
UC Riverside
Title: "Root-Knot Nematode Perception and Immune Signaling in Arabidopsis"
Host: Shahid Siddique, assistant professor, UC Davis Department of Entomology and Nematology
For any technical issues, reach coordinator Shahid Siddique at ssiddique@ucdavis.edu.
- Author: Kathy Keatley Garvey
The nematode collection featured mostly root-knot nematodes and Ascaris (roundworm) nematodes. The display included:
- What's in the jar?
- Celery infected with root-knot nematodes
- Tree swallow infected with Diplotriaena
- White-tailed deer eye infected with a Thelazia species
- Peach root infected with root-knot nematodes
- Mormon crickets infected with Gordius robustus
- Lettuce infected with root-knot nematodes
- Garlic damaged by Ditylenchus dipsaci
- Horse stomach infected with three parasites: Parascaris (roundworms), tapeworms, and botfly larvae.
- Grape roots infected with root-knot nematodes
- Sweet potato infected with root-knot nematodes
- Sugar beet infected with cyst nematodes
- Peach root infected with cyst nematodes
- Sugar beet infected with root-knot nematodes
- Ascaris lumbricoides (roundworm)
- Minke whale infected infected with ascaridoid nematodes
- Heartworm of dog
"Plant-parasitic nematodes are destructive pests causing losses of billions of dollars annually," Siddique says on his website. "Economic, health, and environmental considerations make natural host plant resistance a preferred strategy for nematode control, but there are limitations to this approach. In many cases, the resistance conferred by resistance genes is partial, and some of the nematodes are able to survive. Similarly, nematode resistance genes are often effective against only one or a few species, whereas plants are exposed to several pathogens in the field. Another concern is the emergence of pathotypes that can overcome resistance. In view of all these limitations, it is important to identify additional mechanisms and tools that can be used to develop novel and sustainable approaches to the management of nematodes."
Research in the Siddique lab focuses on basic as well as applied aspects of interaction between parasitic nematodes and their host plants, he says. "The long-term object of our research is not only to enhance our understanding of molecular aspects of plant–nematode interaction but also to use this knowledge to provide new resources for reducing the impact of nematodes on crop plants in California."
Nematologist Steve Nadler, professor and chair of the UC Davis Department of Entomology and Nematology, explains what a nematode is on this YouTube video that he presented at last year's UC Davis Biodiversity Museum Day. Due to COVID-19 precautions, the 2021 event was virtual, instead of in-person.
Visitors to the 2022 UC Davis Biodiversity Museum Day adhered to the Campus Ready guidelines, with masks required. Eleven museums or collections participated:
- Arboretum and Public Garden
- UC Davis Bee Haven
- Bohart Museum of Entomology
- Botanical Conservatory
- California Raptor Center
- Center for Plant Diversity
- Department of Anthropology Museum
- Museum of Wildlife and Fish Biology
- Nematode Collection
- Paleontology Collection
- Phaff Yeast Culture Collection
In addition, visitors could register for side trips to the Arboretum and Public Garden, Bee Haven and Phaff Yeast Culture Collection. The Botanical Conservatory opened its doors to visitors throughout the day.
Traditionally, the UC Davis Biodiversity Museum Day takes place the Saturday of Presidents' Weekend, and at the individual locations, noted organizer Tabatha Yang, education and outreach coordinator. This year it occurred at one site, exposition-style.
The campus is now gearing up for the 108th annual UC Davis Picnic Day, set April 23 and themed "Rediscovering Tomorrow." The free public event is the first, in-person Picnic Day in two years.
- Author: Kathy Keatley Garvey
Well, how about nematodes? They can do "tricks," too.
Professor and plant pathology researcher Melissa Mitchum of the Department of Pathology, University of Georgia, willpresent the next UC Davis Department of Entomology and Nematology seminar.on "The Tricks Phytonematodes Use to Modulate Plant Development."
Her virtual seminar begins at 4:10 p.m., Pacific Time, on Wednesday, March 9, announced seminar coordinator and nematologist Shahid Siddique, assstant professor, UC Davis Department of Entomology and Nematology.
"Phytonematodes secrete a suite of effectors to modulate developmental programs of their hosts to cause disease," Mitchum says in her abstract. 'In this talk, I will highlight what we are learning about these effectors and the tricks they use to accomplish their goals."
Along with colleague Lisa Beamer of the University of Missouri, Mitchum is co-directing a four-year $1.2 million grant from the joint National Science Foundation and the U.S. Department of Agriculture National Institute of Food and Agriculture Plant-Biotic Interactions Program "to help combat a devastating soybean pathogen," according to a January 2022 news article in the Johnson City Press, Tenn. "The soybean cyst nematode, a microscopic roundworm, is responsible for annual crop losses of $1 billion in the U.S. alone," the news story relates.
Mitchum's research focuses "on molecular plant-nematode interactions with an emphasis on the sedentary endoparasitic cyst and root-knot nematodes," Mitchum says on her website. "Pathosystems include cyst (Heterodera glycines) nematode on soybean, cyst (Vittitadera zeaphila) nematode on corn, and root-knot (Meloidogyne spp.) nematodes on soybean, cotton, and peanut. We utilize the model plant Arabidopsis to accelerate our studies to dissect the molecular basis of parasitism by cyst (Heterodera schachtii) and root-knot nematodes. Our work addresses plant responses during compatible and incompatible plant-nematode interactions, the identification and functional analysis of nematode stylet-secreted effector proteins, and developmental reprogramming of host root cells via peptide mimicry and phytohormone manipulation. I work closely with plant breeders to develop high yielding, nematode resistant varieties. Current efforts are also focused on translating basic discoveries to develop novel approaches for nematode resistance in crop plant."
Mitchum received her bachelor's degree in biology in 1993 from the University of Puget Sound, Tacoma, Wash., and her master's degree in plant pathology from the University of Nebraska, Lincoln, in 1995. She obtained her doctorate in plant pathology, with a minor in biotechnology, from North Carolina State University, Raleigh, in 2001. Mitchum served as a postdoctoral fellow with the Developmental, Cell and Molecular Biology Group at Duke University in 2003.
For any seminar technical issues, Siddique may be reached at ssiddique@ucdavis.edu.
Want to learn the basics of nematodes, aka roundworms? Be sure to watch nematologist Steve Nadler, professor and chair of the UC Davis Department of Entomology and Nematology in this YouTube video. He delivered this presentation virtually at the 2021 UC Davis Biodiversity Museum Day. He discusses what they are and why they're important to the ecosystem.
- Author: Kathy Keatley Garvey
How do they know?
Molecular biologist Adam Steinbrenner, an assistant professor of biology at the University of Washington, will explain his research at a UC Davis Department of Entomology and Nematology seminar on Wednesday, Feb. 23.
His public seminar, titled "Plant Immune Recognition of Insect Herbivores," will be both in-person and virtual. It begins at 4:10 p.m. (Pacific Time) in 122 Briggs Hall. The Zoom link is https://ucdavis.zoom.us/j/99515291076.
Steinbrenner and his team were the first to identify an immune recognition mechanism that sounds the alarm against chewing insects.
"From the moment of initial encounter with an insect herbivore, a suite of inducible plant defenses are triggered; however, the molecular mechanisms for recognition and response are not highly studied," Steinbrenner writes in his abstract. "Specific molecular patterns from insects can serve as elicitors of defense responses on host plants, but precise receptors mediating such responses have remained elusive. We recently identified a cell surface receptor, Inceptin Receptor (INR), which detects a set of ubiquitous peptide fragments found in the oral secretions of Lepidopteran larval herbivores. INR is specific to select legume species and may structure insect host range across this plant family. We hypothesize that INR serves as a recently evolved and highly potent mechanism to perceive a specific danger signal, above and beyond cues associated with generic tissue damage. I will discuss our recent transcriptiomic characterization of inceptin responses in bean and cowpea, highlighting strong anti-herbivore defense outputs which occur after inceptin treatment but not wounding alone. I will also compare plant responses to herbivory with well-characterized pathways mediating recognition of microbial pathogens.".
The Steinbrenner lab studies the molecular bases of plant immunity to pathogens and pests. "We are specifically interested in recognition and signaling functions of cell surface receptors and evolutionary processes driving novel immune specificity," he says on his website. He holds a bachelor of science degree in biology from Tufts University (2010) and a doctorate from UC Berkeley in plant biology (2015). He was awarded a Howard Hughes Medical Institute Postdoctoral Fellowship of $180,000 in 2016 and studied with Eric Schmelz at UC San Diego.
Steinbrenner served as the lead author of a paper published Nov. 23, 2021 in the Proceedings of the National Academy of Sciences on how cowpea plants detect that they're being eaten by caterpillars. In the article, A Receptor-Like Protein Mediates Plant Immune Responses to Herbivore-Associated Molecular Patterns, scientists from the University of Washington and UC San Diego reported that the cowpea plants harbor receptors on the surface of their cells that can detect a compound in caterpillar saliva and initiate anti-herbivore defenses.
"Despite chemical controls, crop yield losses to pests and disease generally range from 20-30 percent worldwide," Steinbrenner related in a University of Washington news release. "Yet many varieties are naturally resistant or immune to specific pests. Our findings are the first to identify an immune recognition mechanism that sounds the alarm against chewing insects.”
Wrote UW science writer James Urton: "The team showed that, in response to both leaf wounds and the presence of a protein fragment specific to caterpillar saliva, the cowpea's INR protein boosts the production of ethylene, a hormone that plants often produce in response to munching by herbivores and other types of environmental stress. The protein fragment in caterpillar spit that elicited this response, Vu-IN, is actually a fragment of a cowpea protein, which gets broken down by the caterpillar as it dines on cowpea leaves." (See full article.)
Nematologist Shahid Siddique, assistant professor, UC Davis Department of Entomology and Nematology, coordinates the Wednesday seminars. For any Zoom technical issues, contact him at ssiddique@ucdavis.edu.
