- Author: Kathy Keatley Garvey
The event, the Eric Conn Memorial Biochemistry Games, not only memorialized a UC Davis plant biochemist, but offered “ZOOM fatigue relief” for UC Davis undergraduate students and Cardiff University students studying biochemistry, said organizer and moderator Walter Leal, UC Davis distinguished professor of molecular and cellular biology.
“They had so much fun,” said Leal, a former chair of the UC Davis Department of Entomology. “Ten years from now, most of these students will be in another field and professions unrelated to biochemistry. Those not remaining in biochemistry will probably forget everything they learned this quarter. However, all students who participated will never forget this experience. In the middle of a pandemic and suffering from ZOOM fatigue, they made new friends across the pond. Eric Conn would be happy to see undergraduate students having this experience.”
UC Davis won the event, but “UC Davis had a competitive advantage because this was their second game,” Leal noted. “Everything was new for Cardiff. Additionally, the contents of our syllabi differ.”
Catherine Rodriguez, a microbiology major, captained the six-member UC Davis Team, known as the Ironic Bonds. Fellow team members: Kelly Brandt (biochemistry and molecular biology major), Jiaying Liu (biological sciences), Aly Lodigiana (cellular biology), Efrain Santos (neurobiology, physiology and behavior) and Mary Aina (psychology).
The Cardiff team: spokesperson Jessie Vaughan, and members Marianna Gisdaki, Kia Blackburn, Ellie Whitworth, Alice Pike, and Anastasia Rouchota.
The event also cemented friendships. “A student from UC Davis reached out to become an electronic pen-pal with Cardiff students,” Leal said, adding that “both Cardiff and UC Davis parents wrote direct emails indicating how pleased they were with the event.”
The deans will exchange hoodies. Also, all participants will receive certificates.
UC Davis Chancellor Gary May delivered the welcoming address. While the students were answering questions, Dr. Dean Blumberg of UC Davis Health fielded questions on COVID-19 vaccines.
Nearly 300 logged-in to see the three games: two preliminary games with UC Davis students competing for slots on the final team, and the UC Davis/Cardiff game. The Ironic Bonds defeated the Gibbs Team in the preliminary. “Every student who played on Wednesday will receive a gift card,” Leal said.
Other judges were Cardiff faculty member D. Dafydd Jones; UC Davis emeritus professor Charles Gasser, and UC Davis distinguished research professor Clark Lagarias, a member of the National Academy of Sciences.
Professor Conn also enjoyed close ties with Professor Gasser. “It was Eric who persuaded Charles, then in the private sector, to apply for a position at UC Davis,” Leal related. “Then when Charles joined UC Davis faculty, Eric gave him his lab, which he used until his retirement.”
Two Cardiff faculty members with links to UC Davis assisted with organizing the event and reading the questions:
- Mark Young, a senior lecturer, lived in Davis as a child while his father Thomas Young, taught brewing at UC Davis
- Wynand van der Goes van Naters, a lecturer, is an associate of Leal's, spanning back to when they both lived and worked in Japan. “His research is also focused on insect olfaction,” Leal said. “He was the person I reached out to make the initial contact.”
Some of the Questions Asked
Some of the questions the students answered at the event:
Question: “What is one of the ways that humans adapt to high altitudes by virtue of what happens to hemoglobin?”
Answer: “Increase production of a compound named 2,3-BPG that leads to increase delivery of oxygen.”
Question: “Which portion of the spike protein moves up and down to either evade the immune system or allow virus entry to the host cell to occur?”
Answer: “The receptor-binding domain.”
Question: “A1c is a blood test that measures your average blood sugar levels over the past 3 months. The A1c test measures the percentage of your red blood cells that have sugar-bound hemoglobin. Which ligand binds to hemoglobin as your blood sugar does, albeit in a reversible fashion?”
Answer: “Carbon dioxide”
Question: “Why can crocodiles stay underwater for such a long time without drowning?”
Answer: “Their hemoglobin binds to bicarbonate and reduces affinity for oxygen (at the tissues).”
Question: “In the so-called UK variant of the SARS-CoV-2 virus the amino acid residue asparagine in the receptor-binding domain at position 501 is replaced by which amino acid?”
Answer: “Tyrosine”
Question: “Why the change of a single amino acid, glutamic acid to valine, in hemoglobin leads to sickle cell disease?”
Answer: “It causes aggregation of hemoglobin due to hydrophobic interactions.”
A poll of the viewers indicated 80 percent felt “very satisfied” with the event. Due to EU regulations, the event will not be posted on YouTube for public viewing.
Professor Conn (1923-2017) was a fellow of the National Academy of Sciences. A member of the UC Davis faculty for 43 years, he was the third recipient of the UC Davis Prize for Teaching and Scholarly Achievement. Described as an excellent teacher and researcher, he received the Academic Senate's Distinguished Teaching Award in 1974 and the Academic Senate's highest honor, the Faculty Research Lecturer Award, in 1977. He won the UC Davis Prize for Undergraduate Teaching and Scholarly Achievement in 1989. See https://youtu.be/TdwJkcjQvbw.
- Author: Kathy Keatley Garvey
A seven-member team from UC Davis will challenge a seven-member team from Cardiff on questions related to biochemistry and COVID-19. The public is invited register for the Zoom event at https://tinyurl.com/dmnftsuj
UC Davis Chancellor Gary May will deliver the welcoming address.
“We will focus on a theme of protein structures, emphasizing two proteins of public interest--specifically, hemoglobin, the carrier of oxygen from the lungs to the tissues,” said organizer-moderator Walter Leal, UC Davis distinguished professor of molecular and cellular biology and a former chair of the UC Davis Department of Entomology and Nematology.
“As I said in class, this protein makes FedEx envious. It carries oxygen from the lungs to the muscles and other cells, drops the load at the destinations, and picks up carbon dioxide and protons to take back to the lungs. It is a multitasking protein. It is never idle unless a person gets COVID-19.”
The March 10th event will actually include three games. Prior to The Big Game will be two preliminary games that will determine the composition of the seven-member UC Davis team that challenges Cardiff.
Ironic Bonds: Catherine Rodriguez, Kelly Brandt, Jiaying Liu, Aly Lodigiani, and Efrain Vasquez Santos
Gibbs Team: Kathryn Vallejo, Yasamin (Yasi) Parsa, Tina Luu, Brandon Matsumoto, and Esha Urs
Game 2 will pit the two champion teams that played off-tube or off-camera.
Alpha Helices: Mary Aina, Daniel Colon, Eva Pak, Stephanie Matsumoto, and Joseph Morrison.
Beta Strand: Shiwani KC, Brycen Carter, Beatrice Ark-Majiyagbe, Samantha Levy, and Erica Arsaga.
The Big Game: “For the UC Davis team that will challenge Cardiff, we will have five players from the winner of Game 1, plus one player from Alpha Helices and one player from Beta Strand,” Leal explained.
While the teams work on the questions, Dr. Dean Blumberg, an epidemiologist and chief of Pediatric Infectious Diseases, UC Davis Children's Hospital, will answer questions about vaccines and vaccinations.
The Eric Conn Biochemistry Quizzes, memorializing a noted plant biochemist known for his research and teaching, drew fundamental biochemistry questions. (See event on YouTube at https://youtu.be/Y9T9ayRXyYE)
"Remote learning is causing ZOOM fatigue and impairing student's ability to focus," Leal writes on the registration page. " We hope that this educational activity will promote physically distant, socially close interactions between undergraduate students and further our institutions' ties."
- Author: Kathy Keatley Garvey
Focusing primarily on vaccines, it was broadcast Wednesday, June 3 on both Zoom and YouTube. UC Davis distinguished professor Walter Leal, organizer and moderator, said that "Zoom viewers had an opportunity to evaluate the event: 84.1% found the symposium very helpful; 88.7% were very satisfied or satisfied."
A few of the comments:
- “This is a great way to get facts to the public.”
- "The format was engaging and dynamic.”
- "I was pleased to see that politics was left out of it.”
- "Appreciated the question and answer format and thought that the questions were very well chosen to highlight important points in the discussion.”
Beekeepers were particularly interested in whether bee sting therapy could have a role in the COVID-19 crisis. Could bee sting therapy prevent the disease or could it be used for patient treatment? In addressing the symposium, honey bee geneticist Robert E. Page Jr., related that some beekeepers have used bee therapy to treat arthritis. Page also commented on a paper published in sciencedirect.com indicating that beekeepers living in the epicenter of the COVID-19 virus in China did not contract the virus, and neither did a group of patients receiving apitherapy.
A beekeeping couple in Maryland told Leal today that they read the sciencedirect.com article about a month ago and are taking bee sting therapy. "(We) are stinging ourselves in case it offers protection because the cost seems low and the potential benefit high," the wife said. "We've done it about 3 times so far, approximately once a week, and so far so good."
Virtual Symposium Attendance
Zoom drew 760 users (from 1,081 registered), with 543 unique viewers from 18 countries. "Zoom registrants were from 35 countries, but I assume that most of them watched the recorded presentation (given the time difference)," Leal said. "In less than 24 hours, the Youtube video https://youtu.be/O4L0OHcZ5Mk reached 3,681 views."
The main program, from 5 to 7 p.m., began with a welcoming address by UC Davis Chancellor Gary May. The keynote speakers:
- Dr. Robert Gallo, who co-discovered that HIV causes AIDS, is the Homer and Martha Gudelsky Distinguished Professor in Medicine; co-founder and director of the University of Maryland School of Medicine's Institute of Human Virology; and co-founder of the Global Virus Network.
- Kate Broderick, who is leading an INOVIO research team in San Diego to develop a DNA vaccine for COVID-19,
- Dr. Dean Blumberg, professor and chief of Pediatric Infectious Diseases, UC Davis Health
- Dr. Allison Brashear, dean of the UC Davis School of Medicine., dean of the UC Davis School of Medicine.
- Dr. Paul Allan Offit, co-inventor of the rotavirus vaccine, and the Maurice R. Hilleman Professor of Vaccinology at the Perelman School of Medicine at the University of Pennsylvania
Also interviewed were Dr. Atul Malhotra, professor of Medicine, Pulmonology, Critical Care, UC San Diego Health, and Dr. Stuart H. Cohen, chief of the Division of Infectious Diseases and director of Hospital Epidemiology and Infection Control, UC Davis School of Medicine.
The pre-program included interviews with retired UC Davis Medical Center nurse Carolyn Wyler of Sacramento, a passenger on the ill-fated Grand Princess cruise ship; and with UC Davis Medical Center nurse Paula Wagner, who took a two-week "vacation" to treat COVID-19 patients at a Boston hospital.
Leal, a fellow of the National Academy of Inventors, a member of the Department of Molecular and Cellular Biology faculty and a former chair of the UC Davis Department of Entomology, organized and moderated two other COVID-19 symposiums.
The first symposium is online at https://bit.ly/2VurK3Z and the second at https://bit.ly/3b8TAau.
- Author: Kathy Keatley Garvey
“We are fortune to obtain Dr. Broderick, who is INOVIO's senior vice president of research and development, as one of our primary speakers,” said UC Davis distinguished professor Walter Leal, symposium organizer and moderator.
The free online symposium will take place from 5 to 7 p.m., Wednesday, June 3 on Zoom and YouTube. A pre-program begins at 4:30 with interviews and questions to accommodate all the material. (To register and view the program, access https://bit.ly/2AgVbxY)
“Dr. Broderick targets deadly infectious diseases and cancers and now she has her sights set on a DNA vaccine for COVID-19,” Leal said, adding that she “brought the first-in-human Lassa fever vaccine into the clinic and advanced the development of a DNA vaccine for the MERS (Middle East respiratory syndrome) virus.”
Over the course of her career, the San Diego-based vaccine expert has authored or co-authored more than 60 peer-reviewed articles. Her team regularly publishes and presents research findings in leading scientific publications and at worldwide conferences. She has participated by invitation at advisory meetings convened by the World Health Organization to discuss DNA vaccines and their delivery.
Broderick is the co-inventor of multiple patents related to DNA vaccine delivery, and has served as a principal investigator on grants, awards, and contracts from leading government agencies and not-for-profit organizations, including the National Institutes of Health, the U.S. Department of Defense, the Small Business Innovation Research program, and including a $56M award from the Coalition for Epidemic Preparedness Innovations (CEPI).
She helped drive the development of novel prototypes and designs of INOVIO's proprietary smart device CELLECTRA®, which delivers the company's DNA medicines directly into cells in the body.
Broderick received her doctorate from the University of Glasgow, Scotland, and conducted post-doctoral research at the University of California, San Diego. She joined INOVIO in 2006. In 2018, Dr. Broderick was named Business Women of the Year by the San Diego Business Journal.
The symposium, with a welcoming address by UC Davis Chancellor Gary May, is expected to draw a widespread audience.
The primary speakers or panelists:
- Dr. Robert Gallo, who co-discovered that HIV causes AIDS, is the Homer and Martha Gudelsky Distinguished Professor in Medicine; co-founder and director of the University of Maryland School of Medicine's Institute of Human Virology; and co-founder of the Global Virus Network.
- Dr. Dean Blumberg, professor and chief of Pediatric Infectious Diseases, UC Davis Health
- Dr. Allison Brashear, dean of the UC Davis School of Medicine.
Renowned honey bee geneticist Robert E. Page, former professor and chair of the UC Davis Department of Entomology, will comment on bee therapy, a possible treatment for COVID-19 treatments (suggested by researchers in China but not yet investigated.) (See https://www.sciencedirect.com/science/article/pii/S0041010120302245)
Retired UC Davis Medical Center nurse Carolyn Wyler of Sacramento, a passenger on the ill-fated Grand Princess cruise ship, will talk about her COVID-19 outbreak experiences from ship to shore (Travis Air Force Base quarantine). Overall, two passengers and one crew member on the Grand Princess died, and 103 tested positive. Wyler and her husband tested negative.
Leal, a fellow of the National Academy of Inventors, a member of the Department of Molecular and Cellular Biology faculty and a former chair of the UC Davis Department of Entomology who has organized and moderated two other COVID-19 symposiums as a public service.
The first symposium is online at https://bit.ly/2VurK3Z and the second at https://bit.ly/3b8TAau.
- Author: Kathy Keatley Garvey
You won't want to miss the UC Davis-based COVID-19 Symposium on Wednesday, June 3.
Dr. Robert Gallo, world-renowned virologist at the forefront of the AIDS epidemic and now targeting COVID-19, will headline the panel of speakers.
The free online symposium, to focus primarily on vaccines, will take place from 5 to 7 p.m., Pacific Daylight Time on Zoom and YouTube. (A pre-program, with interviews and questions, begins at 4:30 p.m.) It's the third in a series of COVID-19 symposiums organized and moderated by UC Davis distinguished professor Walter Leal as a public service.
Panelists will discuss:
- Is the polio vaccine a solution?
- Are the front-runner vaccines safe and effective? If so, when might they be available?
Gallo, who co-discovered that HIV causes AIDS, is the Homer and Martha Gudelsky Distinguished Professor in Medicine; co-founder and director of the University of Maryland School of Medicine's Institute of Human Virology; and co-founder of the Global Virus Network. He will be joined by Dr. Dean Blumberg, professor and chief of Pediatric Infectious Diseases, UC Davis Health; and Dr. Allison Brashear, dean of the UC Davis School of Medicine, among others.UC Davis Chancellor Gary May will deliver the welcoming address.
Also interviewed will be Dr. Atul Malhotra, professor of Medicine, Pulmonology, Critical Care, UC San Diego Health, and Dr. Stuart H. Cohen, chief of the Division of Infectious Diseases and director of Hospital Epidemiology and Infection Control, UC Davis School of Medicine. (See program at https://bit.ly/2AgVbxY)
Renowned honey bee geneticist Robert E. Page, former professor and chair of the UC Davis Department of Entomology, will comment on bee therapy, a possible treatment for COVID-19 treatments (suggested by researchers in China but not yet investigated.) (See https://www.sciencedirect.com/science/article/pii/S0041010120302245)
Retired UC Davis Medical Center nurse Carolyn Wyler of Sacramento, a passenger on the ill-fated Grand Princess cruise ship, will talk about her COVID-19 outbreak experiences from ship to shore. She and her husband were quarantined in their room for six days. They then spent 13 days in quarantine at Travis Air Force Base before being released. (Both tested negative.) A 71-year-old passenger on the same ship, but on a different cruise, was the first in California to succumb from the disease. Overall, two passengers and one crew member on the Grand Princess died, and 103 tested positive. (Read her amazing story on Ipinion Syndicate: "No one wanted us," she wrote.)
To register, post questions, and to link to the list of panelists, access https://bit.ly/2B2YGZm.
Among those asking questions will be Jennifer Cash, newest faculty member of the UC Davis College of Biological Sciences; Fred Gould, National Academy of Sciences member; UC Cooperative Extension advisor Surendra Dara; and University of Brasilia graduate student Raquel Silva.
Leal, a fellow of the National Academy of Inventors, a member of the Department of Molecular and Cellular Biology faculty and a former chair of the UC Davis Department of Entomology, is hosting the symposiums as a public service.
The first symposium is online at https://bit.ly/2VurK3Z. "You are our heroes," one viewer wrote.
The second symposium can be accessed at https://bit.ly/3b8TAau. "It was a great symposium--the personal story of the frontline physician was incredible,” one viewer wrote. Added another viewer: "Well, what an amazing finale and yes, we are taking it seriously, especially those of us older office workers. What a story of your life and death experience. Amazing presentation!" And another: "Congratulations on today's new webinar. It was excellent again. I look forward to the next one."
One more thing about the third COVID-19 symposium on June 3: Leal's interview with Gallo, who is as humble a person as you'd ever want to meet, is a must-see. Learn what sparked his interest in virology, what fueled his dreams, and why he doesn't plan to retire. Ever. Very moving.
