Take the case of a male monarch reared, released and tagged by Steven Johnson in a Washington State University citizen-science project operated by WSU entomologist David James. Johnson tagged and released the monarch on Sunday, Aug. 28, 2016 in Ashland, Ore. Seven days later, on Sept. 5, it fluttered into our family's backyard pollinator garden in Vacaville, Calif., where we photographed it.
"So, assuming it didn't travel much on the day you saw it, it flew 285 miles in 7 days or about 40.7 miles per day," James said. "Pretty amazing." (See Bug Squad blog)
But how do monarchs know when to migrate? You can find out when you attend the UC Davis Bohart Museum of Entomology open house on Saturday, Jan. 18 from 1 to 4 p.m. in Room 1124 of the Academic Surge Building, Crocker Lane.
Doctoral student Yao Cai, a fourth-year doctoral student in the Joanna Chiu lab who studies circadian clocks in insects, will relate how monarchs know when to migrate. “Using Drosophila melanogaster (fruit fly) and Danaus plexippus (monarch butterfly), as models, we seek to understand how these insects receive environmental time cues and tell time, how they organize their daily rhythms in physiology and behavior, such as feeding, sleep and migration (in monarch butterfly)," he says.
Cai is one of six doctoral students who will be showcasing their research. The event is free and family friendly.
Visitors not only will have the opportunity to talk to graduate students about their research and glean information about insects, but will be able see their work through a microscope. In fact, eight microscopes will be set up, Yang said.
In addition to Cai, doctoral students participating and their topics:
Ants: Zachary Griebenow of the Phil Ward lab, UC Davis Department of Entomology and Nematology
Assassin flies: Charlotte Herbert Alberts, who studies with major professor Lynn Kimsey, director of the Bohart Museum, UC Davis Department of Entomology and Nematology
Bats (what insects they eat): Ecologist Ann Holmes of the Graduate Group in Ecology, Department of Animal Science, and the Genomic Variation Laboratory, who studies with major professors Andrea Schreier and Mandi Finger.
Bark Beetles: Crystal Homicz. who studies with Joanna Chiu, UC Davis Department of Entomology and Nematology and research forest entomologist Chris Fettig, Pacific Southwest Research Station, USDA Forest Service, Davis.
Forensic entomology: Alexander Dedmon, who studies with Robert Kimsey, UC Davis Department of Entomology and Nematology
Some doctoral students also will deliver PowerPoint presentations or show slides. The projects:
“Did you know that between 1987 and 2017 bark beetles were responsible for more tree death than wildfire?” asks Crystal Homicz, a first-year doctoral student. “Bark beetles are an incredibly important feature of forests, especially as disturbance agents. My research focuses on how bark beetles and fire interact, given that these are the two most important disturbance agents of the Sierra Nevada. At my table, I will discuss how the interaction between bark beetles and fire, why bark beetles and fire are important feature of our forest ecosystem, and I will discuss more generally the importance of bark beetles in many forest systems throughout North America.
“I will have several wood samples, insect specimens and photographs to display what bark beetle damage looks like, and the landscape level effects bark beetles have. I will also have samples of wood damage caused by other wood boring beetles and insects. My table will focus widely on the subject of forest entomology and extend beyond beetle-fire interactions.”
Visitors, she said, can expect to leave with a clear understanding of what bark beetles are and what they do, as well as a deeper understanding of the importance of disturbance ecology in our temperate forests.
Charlotte Alberts, a fifth-year doctoral candidate, will display assassin flies and their relatives, as well as examples of prey they eat and/or mimic. Visitors can expect to learn about basic assassin fly ecology and evolution. Alberts studies the evolution of assassin flies (Diptera: Asilidae) and their relatives.
“Assassin flies are voracious predators on other insects and are able to overcome prey much larger than themselves,” she said. “Both adult and larval assassin flies are venomous. Their venom consists of neurotoxins that paralyze their prey, and digestive enzymes that allow assassin flies to consume their prey in a liquid form. These flies are incredibly diverse, ranging in size from 5-60mm, and can be found all over the world! With over 7,500 species, Asilidae is the third most specious family of flies. Despite assassin flies being very common, most people do not even know of their existence. This may be due to their impressive ability to mimic other insects, mainly wasps, and bees.”
For her thesis, she is trying to resolve the phylogenetic relationships of Asiloidea (Asilidae and their relatives) using Ultra Conserved Elements (UCEs), and morphology. "I am also interested in evolutionary trends of prey specificity within Asilidae, which may be one of the major driving forces leading to this family's diversity."
Ecologist Ann Holmes, a fourth-year doctoral student, is studying what insects that bats eat. "I will be talking about my research project that looks at insects eaten by bats in the Yolo Bypass. The insects eat crops such as rice, so bats provide a valuable service to farmers. Hungry bats can eat as much as their own body weight in insects each night."
"Visitors can expect to learn how DNA is used to detect insects in bat guano (poop)." "Insects in bat poop are hard to identify because they have been digested, but I can use DNA to determine which insects are there," she said. "We care about which insects bats eat because bats are natural pest controllers. With plenty of bats we can use less pesticide on farms and less mosquito repellent on ourselves."
Zachary Griebenow, a third-year doctoral student, will be showcasing or discussing specimens of the ant subfamily Leptanillinae, most of them male. “I will be showing specimens of the Leptanillinae under the microscope, emphasizing the great morphological diversity observed in males and talking about my systematic revision of the subfamily," he said. "In particular, I want to explain how the study of an extremely obscure group of ants can help us understand the process of evolution that has given rise to all organisms."
Forensic entomologist Alex Dedmon, a sixth-year doctoral student, will display tools and text and explain what forensic entomology is all about. "My research focuses on insect succession. In forensic entomology, succession uses the patterns of insects that come and go from a body. These patterns help us estimate how long a person has been dead. Visitors can expect to learn about the many different ways insects can be used as evidence, and what that evidence tells us."
Other Open House Activities
The family craft activity will be painting rocks, which can be taken home or hidden around campus. "Hopefully some kind words on rocks found by random strangers can also make for a kinder better future,” said Yang.
In addition to meeting and chatting with the researchers, visitors can see insect specimens (including butterflies and moths), meet the critters in the live “petting zoo” (including Madagascar hissing cockroaches, walking sticks and tarantulas) and browse the gift shop, containing books, insect-themed t-shirts and sweatshirts, jewelry, insect-collecting equipment and insect-themed candy.
The Bohart Museum, directed by Professor Lynn Kimsey and founded by noted entomologist Richard M. Bohart (1913-2007), houses a global collection of nearly eight million specimens. It is also the home of the seventh largest insect collection in North America, and the California Insect Survey, a storehouse of insect biodiversity.
The insect museum is open to the public Mondays through Thursdays from 9 a.m. to noon and 1 to 5 p.m., except on holidays. More information on the Bohart Museum is available on the website at http://bohart.ucdavis.edu or by contacting (530) 752-0493 or firstname.lastname@example.org.
If you've been finding more milkweed bugs than monarchs on your milkweed, join the crowd.
Monarchs are scarce--at least around Solano and Yolo counties--but milkweed bugs are quite plentiful. Sometimes you see them massing on milkweed pods as if they're having a family reunion and trying to figure out who's who during an all-you-can eat buffet. They're blood red, in sharp contrast to the green plants.
Have you seen the large milkweed bugs, Oncopeltus fasciatus, and the small milkweed bugs Lygaeus kalmii? Both belong to the seed bug family, Lygaedidae. We recently spotted small milkweed bugs on a patch of showy milkweed (species Asclepias speciosa) in Sonoma.
Milkweed bugs are primarily seed eaters, but they're opportunistic and generalists, says Hugh Dingle, emeritus professor of the UC Davis Department of Entomology and Nematology, an insect migration biologist who also researches migratory monarchs.
"They'll get protein from wherever they can find it," said Dingle, author of the popular textbook, Animal Migration: the Biology of Life on the Move. They eat not only eat seeds, but also monarch eggs and larvae and the immature stages of other butterflies, Dingle told us back in 2016. They eat other small bugs and feed on nectar as well. Some scientists have seen them feeding on insects trapped in the sticky pollen of the showy milkweed. (Read about the opportunist Small Milkweed Bug in the Journal of the New York Entomological Society.)
The bugs feed on the toxic milkweed, rendering them distasteful to predators. Their warning colors (red and black) also tell prospective predators "Leave me alone; I don't taste good. If you eat me, you'll be sorry." They sequester and store cardenolides (cardiac glycosides) from the milkweed.
In the fall, as the seed pods burst open, monarch enthusiasts scramble to collect the seeds for next year, but they usually have to compete with the red invaders.
If they're still around...
Have you ever seen the larva of a lady beetle (aka ladybug) dining on an aphid?
Lights! Camera! Action!
So here is this charming little immature lady beetle chowing down on an oleander aphid that has the audacity to infest the milkweed in our pollinator garden. Chomp! Crunch! Slurp! And then another aphid arrives on the scene. It does not flee. Aphids are not the smartest of insects.
Can you just wait! Hold on! I'm not finished eating this one, yet!
And then an adult lady beetle arrives. She ignores a fat aphid right before her very eyes. Shall we prey?
Can you just wait! Don't go away! I'll eat you when I'm hungry!
A lady beetle (it's not a bug, it's a beetle!) belongs to the family Coccinellidae. Scientists have described about 5000 species worldwide, and about 450 in North America.
How many aphids can a lady beetle eat in her lifetime of three to six weeks? An estimated 5000 aphids, according to the University of Kentucky Cooperative Extension Service.
That's great pest control!
One thing is for sure: the lady beetles and their offspring patrolling our milkweed plants will never experience famine. This is an all-you-can-eat buffet, and the aphids just keep on a'coming. They do not flee. Aphids are not the smartest of insects.
Now, where are the monarchs? We have milkweed waiting./span>
No monarchs this time of year, you say?
Well, this one was little Saathiya Patel, 4, riding the shoulders of her Pollinator Posse-father, Seth Newton Patel of Oakland. When he tossed her in the air, she spread her wings!
What a joy to see!
Art Shapiro, distinguished professor of evolution and ecology, delivered his second annual presentation on butterflies, this one on "Are Butterflies Heralds of the Insect Apocalypse?" (more about that later).
Meanwhile, it's good to see the Pollinator Posse, co-founded by Tora Rocha and Terry Smith, helping out our beleaguered butterflies and native bees.
Rocha and Smith formed the Pollinator Posse (see their Facebook page) in Oakland in 2013 to create pollinator-friendly landscaping in urban settings and to foster appreciation of local ecosystems through outreach, education and direct action.
Rocha, a retired Oakland parks supervisor, says that eco-friendly landscape techniques are at the heart of their work. "We teach respect for the creatures which keep Oakland--and the world--blooming."
"We envision a day when life-enhancing, thought-inspiring green spaces will grace every corner of the city and the world beyond," Rocha says.
This is a dedicated group, committed to making a difference, and what a difference they are making! Their activities include rearing monarchs and other butterflies; encouraging folks to plant the host plant and nectar sources; showing children how to make bee condos or bee hotels--AirBeeNBees--for native bees; and hosting "Tees for Bees," at which youths visit golf courses to hit pollinator friendly seed balls "which help make the courses more habitable for beneficial insects," Rocha says. (See news story on Best Garden Whiz and Butterfly Savior: Victoria 'Tora' Rocha.)
Tora Rocha and her fellow Pollinator Posse love it when monarchs take flight. So do we. And so does Pollinator Posse member Seth Newton Patel and his daughter, Saathiya, already a monarch enthusiast at age 4.
A member of the UC Davis faculty since 1980, Hammock received his doctorate in entomology and toxicology from UC Berkeley, where he studied insect science. He now devotes his research to human health.
What many people do not know, however, is that he began his career studying how caterpillars turn into butterflies.
That morphed into human health research.
“The work led to the discovery that many regulatory molecules are controlled as much by degradation and biosynthesis,” Hammock related. “The epoxy fatty acids control blood pressure, fibrosis, immunity, tissue growth, pain and inflammation to name a few processes.”
Fast forward to today.
An enzyme inhibitor developed in the Hammock lab and tested in mice by a team of international researchers shows promise that it could lead to a drug to prevent or reduce the disabilities associated with the neurodevelopmental disorders of autism and schizophrenia.
What the Inhibitor Did
"We discovered that soluble epoxide hydrolase (sEH) plays a key role in inflammation associated with neurodevelopmental disorders. Inhibiting that enzyme stops the inflammation and the development of autism-like and schizophrenia-like symptoms in animal models,” said collaborator Kenji Hashimoto, a professor with the Chiba University Center for Forensic Mental Health, Japan. The scientists found higher levels of sEH in a key region of the brain—the prefrontal cortex of juvenile offspring-- after maternal immune activation (MIA).
The news embargo lifted today (March 18) on their research, to appear in the Proceedings of the National Academy of Sciences (PNAS). (Link will be here: https://www.pnas.org/cgi/doi/10.1073/pnas.1819234116.) It's the work of 14 researchers from Chiba University Center for Forensic Mental Health; the Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, in Wako, Saitama, Japan; and the Hammock laboratory.
Reversed Cognitive and Sciatl Interaction Deficiencies
By inhibiting sEH, the researchers reversed cognitive and social interaction deficiencies in the mice pups. They hypothesize that this is due to increasing natural chemicals, which prevent brain inflammation. In people, this could reduce the disabilities associated with autism, such as anxiety, gastrointestinal disturbances and epilepsy.
Earlier studies have indicated a genetic disposition to the disorders. The team also studied postmortem brain samples from autism patients that confirmed the alterations.
“In the case of both autism and schizophrenia, the epidemiology suggests that both genetics and environment are contributing factors,” said neuroscientist and associate professor Amy Ramsey of the Department of Pharmacology and Toxicology, University of Toronto, who was not involved in the study. “In both cases, maternal infection is a risk factor that might tip the scales for a fetus with a genetic vulnerability. This study is important because it shows that their drug can effectively prevent some of the negative outcomes that occur with prenatal infections. While there are many studies that must be done to ensure its safe use in pregnant women, it could mitigate the neurological impacts of infection during pregnancy.”
Neuroscientist Lawrence David, professor and chair of the School of Public Health, University of Albany, N.Y., who was not involved in the research, said that the study might lead to “an important therapeutic intervention for neurodevelopment disorders.”
“There is increasing evidence that maternal immune activation activities (MIA) during fetal development can lead to aberrant neurobehaviors, including autistic-like activities,” said Lawrence, who studies neuroimmunology and immunotoxicology. The study “suggests that enzymatic control of fatty acid metabolism is implicated in neuroinflammation associated with schizophrenia and autism spectrum disorders. The expression of Ephx2 giving rise to soluble epoxide hydrolase (sEH) influences production of fatty acid metabolites, which elevate inflammation in the experimental model of mice after MIA; the sEH inhibitor TPPU (N-[1-(1-oxopropyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl)-urea) was postnatally used to improved behaviors. Analysis of cadaver brains from individuals with ASD also expressed increased sEH. Fatty acid metabolites have been known to affect fetal development, especially that of the brain; therefore, TPPU might be an important therapeutic intervention for neurodevelopmental disorders.”
Molecular bioscientist Isaac Pessah of the UC Davis School of Veterinary Medicine, distinguished professor and associate dean of research and graduate education in the Department of Molecular Biosciences, described the findings as “significant” and called for more detailed and expanded studies.
Autism: 1 of 68 Children
The Center for Disease Control and Prevention (CDC) estimates that 1 in 68 children in the United States have autism, commonly diagnosed around age 3. It is four times more common in boys than girls. CDC defines autism spectrum disorder as a “developmental disability that can cause significant social, communication and behavioral challenges.” The disorder impairs the ability to communicate and interact.
Schizophrenia: 1.2 Percent of Population
Approximately 3.5 million people or 1.2 percent of the population in the United States are diagnosed with schizophrenia, one of the leading causes of disability, according to the Schizophrenia and Related Disorders Alliance of America (SARDAA). Scores more go unreported. Approximately three-quarters of persons with schizophrenia develop the illness between 16 and 25 years of age. Statistics also show that between one-third and one half of all homeless adults have schizophrenia, and 50 percent of people diagnosed have received no treatment. Among the symptoms: delusions, hallucinations, disorganized speech, disorganized or catatonic behavior, and obsessive-compulsive disorders, such as hoarding, according to SARDAA.
In their research paper, titled “Key Role of Soluble Epoxide Hydrolase in the Neurodevelopmental Disorders of Offspring After Maternal Immune Activation,” the scientists described sEH as “a promising prophylactic or therapeutic target for neurodevelopmental disorders in offspring after MIA.”
First author Min Ma and second Qian Ren of the Hashimoto lab conducted the animal and biochemical work, while chemists Jun Yang and Sung Hee Hwang of the Hammock lab performed the chemistry and analytical chemistry. Takeo Yoshikawa, a team leader with the RIKEN's Molecular Psychiatry Laboratory, performed measurements of gene expression in the neurospheres from iPSC (induced pluripotent stem cells) from schizophrenia patients and postmortem brain samples from autism patients.
Exciting and Productive
Hashimoto described the international collaboration as “exciting and productive.” This is their third PNAS paper in a series leading to endoplasmic reticulum stress. “We report discovery of a biochemical axis that leads to multiple neurological disorders, including depression, Parkinson's disease, schizophrenia, autism spectrum disorders and similar diseases,” he said.
William Schmidt, vice president of clinical development at EicOsis, a Davis-based company developing inhibitors to sEH to treat unmet medical needs in humans and companion animals, said the company is developing a first-in-class therapy for neuropathic and inflammatory pain. “EicOsis is in the process of finalizing our first human trials on the inhibitors of the soluble epoxide hydrolase, originally reported from UC Davis,” Schmidt said. “We are targeting the compounds as opioid replacements to treat peripheral neuropathic pain. It is exciting that the same compound series may be used to prevent or treat diseases of the central nervous system.”
Several grants from the National Institutes of Health, awarded to Hammock, supported the research. Hammock praised the many collaborators and students he has worked with on the project. “This work illustrates the value of research universities in bringing together the diverse talent needed to address complex problems,” Hammock said. “It also illustrates the value of fundamental science. This autism research can be traced directly to the fundamental question of how caterpillars turn into butterflies.”