- Author: Kathy Keatley Garvey
The Academic Senate, acknowledging that the University of California “has a long tradition of service to the state and the people of California” and that “faculty members use their expertise in teaching, research, and professional competence to make unpaid contributions to local, statewide, national, or international public arenas,” annually singles out an exceptional faculty member who “continues the tradition and demonstrate the commitment of UC Davis to public service.”
“Distinguished Professor Walter Leal helped to address the critical need for accurate and accessible COVID-19 information,” according to the Academic Senate notice. “He conceptualized, organized, and moderated four COVID-19 symposia for the public. Through meticulous research, he brought together physicians, former patients, and public health experts to provide the most up-to-date information early in the pandemic, including highlighting equity gaps in treatment.”
“Professor Leal dedicated much of his sabbatical time to developing valuable public resources, thus providing high-quality information during a time of rampant misinformation,” the Academic Senate related. “He also champions global learning, putting long-term efforts into global collaborations to enhance education.”
Gov. Gavin Newsom's issued a stay-at-home order on March 19, 2020, and the following day, UC Davis Chancellor Gary May told the campus community: “Most of our employees should already be at home where the governor wants you to be, and where we want you to be, for the sake of your own health and to help limit the spread of the coronavirus.”
“On March 22 came the first reported death from COVID in Yolo County,” wrote Hammock, who holds a joint appointment with the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. “On April 23, Distinguished Professor Walter Leal, as a timely service to the UC Davis community and the general public, organized and moderated the first of his COVID-19 symposiums. What Dr. Leal did, and did so well in the throes of the raging pandemic, was to help the UC Davis community and the general public understand a disease that would go on to claim the lives of nearly 800,000 Americans. Two weeks prior to each symposium, he worked daily from 5 a.m. to 11 p.m., reading the scientific literature, interviewing experts, lining up the speakers; gathering relevant questions from the public, and generally, taking care of all the logistics."
You Are My Heroes. The webinars drew scores of comments. “You are my heroes,” wrote one viewer. “This [the symposium] gave me a sense of hope and calmed my anxiety like nothing else. Part of what has been so hard is all the disinformation and complete lies and contradictions that are happening daily. To hear people, real doctors and scientists who are knowledgeable talk about what is going on and why is so appreciated! I learned so much; wish you were the ones leading [our] government through this! Having a family zoom tonight to relay the info! I (offer) much gratitude to UC Davis! My husband says ditto.”
Professor Leal's plans for a single webinar quickly grew to three more to meet the growing demand of information and translation.
“Few are aware that Dr. Leal interrupted his sabbatical leave to complete his mission,” Hammock pointed out. “Personally, this was not unusual. Having known Dr. Leal for more than two decades, I am fully aware of how altruistic and dedicated he is. He firmly believes that a primary mission of a land-grant university is to serve the public.”
A native of Brazil and fluent in three languages, Leal was educated in Brazil, Japan and the United States, pursuing the scientific fields of chemical engineering, agricultural chemistry, applied biochemistry, entomology and chemical ecology. After serving in a leadership capacity in Japan's Ministry of Agriculture, Forestry, and Fisheries for five years, he joined the Department of Entomology faculty in 2000. Leal chaired the department from 2002 to 2013 before accepting an appointment as a professor of biochemistry with the Department of Molecular and Cellular Biology.
Widely known for his research, teaching and mentorships, Leal is an elected Fellow of the National Academy of Inventors, American Association for the Advancement of Science, California Academy of Sciences, Royal Entomological Society and the Entomological Society of America (ESA). The UC Davis Academic Senate named him the recipient of its 2020 Distinguished Teaching Award for Undergraduate Teaching, and the Pacific Branch of ESA presented him with its 2020 Award of Excellent in Teaching.
A Treasured Note. Leal treasures a handwritten note from a 12-year-old boy, who (according to his mother) was struggling with autism. “Dear Scientist, I hope you can make the vaccine for the coronavirus and to make us live forever,” the boy wrote. “And you can do it. We believe in you. Love XX.”
His mother updated the UC Davis professor in the fall of 2021: “ (XX) wanted me to tell you that he feels so much safer now that he has the vaccine! He is so thankful for all the scientists working so hard to find a solution to make the world safer and continue researching to prevent additional variant outbreaks. He is back in school full time now and is enjoying being able to be with his teachers and classmates.”
- Author: Kathy Keatley Garvey
The award is part of the Revolutionizing Innovative, Visionary Environmental Health Research (RIVER) Program of the National Institutes of Environmental Health (NIEHS). This award is based on a track record of innovation and a ‘visionary' proposal to address serious problems in environmental health.
Hammock, who holds a joint appointment with the UC Davis Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Society, is known for his expertise in chemistry, toxicology, biochemistry and entomology. He meshes all four sciences in his 50-year research on how environmental chemicals impact human health.
“I am thrilled to receive the RIVER award,” said Hammock, who joined the UC Davis faculty in 1980 and now devotes much of his research toward environmental health. “The National Institutes of Health has many institutes and several of them have funded my laboratory over the years. But it is the NIEHS that most closely matches my interests. They have supported my work since I was a graduate student, so I am particularly thrilled they have shown such high confidence in the science and work our laboratory does. This award certainly recognizes the current and past members of the laboratory who have been so productive and innovative.”
The program provides $6 million in funding over an eight-year period “to give scientists greater intellectual and administrative freedom as well as sustained support to achieve greater scientific impact,” according to NIEHS officials. RIVER provides a select few scientists with great latitude in addressing the most pressing scientific problems.
“Professor Hammock is especially deserving of this recognition for his important research over many years,” said Helene Dillard, dean of the UC Davis College of Agricultural and Environmental Sciences. “Environmental health is central to the mission of our college, and we anticipate that this award will empower him to continue making advances in areas with the potential to impact human well-being.”
Ken Burtis, faculty advisor to the Chancellor and Provost and past Dean of Biological Sciences at UC Davis, said it would be difficult to find “a more deserving scientist to invest in than Bruce Hammock.”
“We both worked in the same building, and Bruce was one of the most hard-working, creative and enthusiastic colleagues I knew,” Burtis said. “The grant process often limits innovation. The intellectual freedom NIEHS is providing Hammock makes our university shine and is a smart investment on the part of the agency. Their investment in him in the past paid off and RIVER will pay off even more in the future.”
When asked how the award would change his life, Hammock, a kayak enthusiast and instructor, responded: “I will give up kayaking the harder rivers, I certainly do not want to drown and have to give any of the funding back. Having been given this great freedom, it will be hard to live up to the expectations.”
Hammock, who has directed the NIEHS-UC Davis Superfund Research Program for the past 35 years, said many of his UC Davis collaborators are affiliated with the Superfund Program, including:
- Professor Aldrin Gomes who holds a joint appointment with the Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, and the Department of Physiology and Membrane Biology, School of Medicine;
- Fawaz Haj, who holds a joint appointment with the Department of Nutrition, College of Agricultural and Environmental Sciences, and the Department of Internal Medicine, School of Medicine
- Research scientist Christophe Morisseau of the Hammock lab, Department of Entomology and Nematology and the Comprehensive Cancer Center, and
- Cardiologist Nipavan Chiamvimonvat of the Division of Cardiovascular Medicine, Department of Internal Medicine, UC Davis Health System
“Bruce had been wonderful supporting students through running a training grant and particularly bringing diverse scientists together with the NIEHS Superfund Program,” said Chiamvimonvat. “It has been such a privilege to be part of this exciting program to understand the mechanisms of environmental contaminants on human health. His pioneering work on novel targets to combat inflammation has far-reaching applications, not only in pain, but also in other diseases including cancer and cardiovascular diseases, the two most common causes of morbidity and mortality.”
Gomes explained that rather than trying to find biological markers for individual environmental chemicals, this Superfund group is working together to find universal markers of stress and disease and understand how to prevent these diseases. ‘By stabilizing mitochondria, the endoplasmic reticulium and other cell organelles to stress,” Gomes said, “we are reducing toxicity, as well as understanding the very basis of tissue damage by commonly used drugs and pesticides and how to reverse it.”
Michael Lairmore, dean of the UC Davis School of Veterinary Medicine, said he was pleased to hear that Hammock has won the NIEHS River Award. “Bruce is very deserving of this award,” Lairmore said. “He has pioneered trans-disciplinary research across campus and has engaged faculty in multiple colleges and schools to transform the way we treat diseases in multiple species. His creative approaches blend his natural curiosity with practical ways to translate his research findings into real world solutions to disease processes.”
“By providing research freedom through the RIVER award to Bruce Hammock, NIH made a remarkable decision,” said Scott Fishman, director of the Center for Advancing Pain Relief, Fullerton Endowed Chair in Pain Medicine, and executive vice chair of the Department of Anesthesiology and Pain Medicine for the UC Davis School of Medicine.
“For example, Bruce sought me out shortly after I arrived at UC Davis with interest in reducing pain and our excessive use of opioids,” Fishman said. “Over time, he went on to develop an experimental pharmaceutical that is a promising unique non-opioid drug for treating chronic pain that will enter human trials this fall. With Hammock as a recipient, the NIH RIVER Program has declared its commitment to recognizing basic scientists who are developing profound solutions that address the opioid crisis.”
Harvard Medical School researcher and former physician, Dipak Panigraphy, said that “The pioneering studies from the Hammock laboratory not only have elucidated how certain environmental contaminants increase cancer risk, but our collaborative work shows promise for preventing metastasis and recurrence of cancer following surgical tumor resection and chemotherapy. These potentially paradigm shifting studies show that preoperative or peri-chemotherapeutic management of inflammation may stave off cancer recurrences.”
Said Hammock: “We would not have this without the scientific and intellectual input of Cindy McReynolds, program manager of the Superfund Program. Of course RIVER is a complement to the existing and past scientists who have worked on this project.”
The RIVER program is “the centerpiece of an emerging effort to support people, not projects, by providing support for much of an independent research program for outstanding investigators and giving them intellectual and administrative freedom, as well as sustained support, to pursue their research in novel directions in order to achieve greater impacts,” according to the NIEHS-RIVER website. “The RIVER program rewards outstanding environmental health sciences researchers who demonstrate a broad vision and potential for continuing their impactful research with increased scientific flexibility, stability in funding, and administrative efficiency.”
Nationally recognized for his achievements, Hammock is a fellow of the National Academy of Inventors, which honors academic invention and encourages translations of inventions to benefit society. He is a member of the U.S. National Academy of Sciences, a fellow of the Entomological Society of America, and the recipient of scores of awards, including the first McGiff Memorial Awardee in Lipid Biochemistry; and the Bernard B. Brodie Award in Drug Metabolism, sponsored by the America Society for Pharmacology and Experimental Therapeutics.
“Bruce Hammock and his research team are the perfect example of how UC Davis translates university research into societal impact,” said Dushyant Pathak, associate vice chancellor for Innovation and Technology Commercialization in the UC Davis Office of Research.
“As a result of their fundamental work in unraveling both insect and human regulatory biology, the Hammock laboratory elucidated a biochemical pathway that regulates inflammation, pain and senescence,” Pathak said. “Enabled by this knowledge, a novel drug candidate to treat chronic pain is expected to enter human phase 1a trials this fall--also supported by NIH. The drug is licensed by the university to EicOsis, a company that is directing its development and is a UC Davis spin-off.”
A native of Little Rock, Ark., Hammock received his bachelor's degree in entomology (with minors in zoology and chemistry) magna cum laude from Louisiana State University, Baton Rouge, in 1969. He received his doctorate in entomology-toxicology from UC Berkeley in 1973 with John Casida at UC Berkeley. Hammock served as a public health medical officer with the U.S. Army Academy of Health Science, San Antonio, and as a postdoctoral fellow at the Rockefeller Foundation, Department of Biology, Northwestern University, Evanston, Ill.
Hammock traces the history of his enzyme research to his studies in the Casida laboratory. He was researching insect developmental biology and green insecticides when he and colleague Sarjeet Gill, now a distinguished professor at UC Riverside, discovered the target enzyme in mammals that regulates epoxy fatty acids.
“My research led to the discovery that many regulatory molecules are controlled as much by degradation and biosynthesis,” Hammock said. “The epoxy fatty acids control blood pressure, fibrosis, immunity, tissue growth, depression, pain and inflammation to name a few processes.”
“Basically, I began by trying to figure out how a key enzyme, epoxide hydrolase, degrades a caterpillar's juvenile hormone, leading to metamorphosis from the larval stage to the adult insect,” Hammock said. He asked himself these questions: “Does the enzyme occur in plants? Does it occur in mammals?" It does, and particularly as the soluble epoxide hydrolase in mammals.
"It is always important to realize that the most significant translational science we do in the university is fundamental science,” said Hammock, marveling that “this work to treat pain in companion animals, horses and humans all began by asking how caterpillars turn into butterflies.”