- Author: Kathy Keatley Garvey
Rain dampened the Crocker Lane event but not the enthusiasm as the crowd toasted the work of the Bohart Museum and its director Lynn Kimsey, UC Davis distinguished professor of entomology. She has administered the Bohart Museum since 1990.
The UC Davis museum traces its origins back in 1946 to two Schmitt boxes filled with insect specimens collected by noted entomologist Richard M. Bohart (1913-2007), UC Davis professor of entomology and museum founder. Named the Bohart Museum in 1982, it is now the home of nearly eight million insect specimens, collected worldwide.
“We should take a moment to not only express our appreciation of the Bohart Museum and the legacy that Dr. Richard Bohart left, but to all the work Lynn has done to make events like this possible and to continue the important work,” emcee Jason Bond, the Evert and Marion Schlinger Endowed Chair and professor, UC Davis Department of Entomology and Nematology, told the crowd.
“Collections have a tremendous educational value,” Bond said, “and they also have amazing research value as well. Discoveries of new species don't actually happen in the field, they happen in the museum collections. New species on the average spend about 25 years on the shelf before a graduate student, undergraduate student or a researcher pulls them off shelf and describes or discovers them.”
He offered a toast to Kimsey, who in turn praised the thousands of collectors “who have their names” on the specimens. “We've been doing this for a long time. Eventually we'll be able to serve the public again like we should. Otherwise it would just be a dead collection in a building somewhere.”
Kimsey interviewed “Doc” Bohart, then 82, in 1996 as part of the Aggie Videos collection. (See https://bit.ly/2Zv8rvO.) Bohart, who began his UC Davis career in 1946, chaired the Department of Entomology from 1963 to 1967.
Unparalleled Research. “His scientific research on insect taxonomy and systematics is unparalleled,” Kimsey wrote on the Bohart website. “His publications include three of the most important books on the systematics of the Hymenoptera, including the well-used volume Sphecid Wasps of the World. His journal publications total over 200 articles. He revised many groups of insects, discovered new host-associations or geographic ranges, and described many new species."
Kimsey, an alumnus of UC Davis, received her undergraduate degree in 1975 and doctorate in 1979. She joined the UC Davis faculty in 1989. A two-term president of the International Hymenopterists, and a recognized global authority on the systematics, biogeography and biology of the wasp families, Tiphiidae and Chrysididae, she won the 2020 C. W. Woodworth Award, the highest award given by the Pacific Branch of the Entomological Society of America, for "her 31 years of outstanding accomplishments in research, teaching, education, outreach and public service."
Entomologist and UC Davis biology manager Ivana Li prepared and served a buffet. Kimsey cut a specially decorated cake, adorned with images of a monarch, a morpho and a dogface butterfly (the state insect), a dragonfly, and assorted beetles. Tiffany Warrick of CreaTions N EvenTs, Rancho Cordova, created the cake and dozens of Bohart-motif cupcakes.
The costumes drew smiles of approval and delight. Bohart senior museum scientist Steve Heydon and his wife, Anita, came dressed as steampunk figures; Bohart education and outreach coordinator Tabatha Yang donned a horse fly costume; entomology major Gwendolyn "Gwen" Erdosh portrayed a monarch butterfly; and UC Davis entomology graduate Benjamin Maples (now a California Department of Food and Agriculture scientist) walked in wearing a lampshade.
With crayons and ink pens, attendees drew insects and pasted them on a piñata, formed in the shape of the number 75. Then, cheered by the crowd, they took turns whacking it, spilling out Halloween candies, and mementos from the UC Davis College of Agricultural and Environmental Sciences.
Financial support. Bond urged the crowd to help support the outreach mission of the museum. Bohart Museum scientists are seeking donations for their traveling insect specimen displays. They aim to raise $5000 by 11:59 p.m., Oct. 31 for their UC Davis CrowdFund project to purchase traveling display boxes for their specimens, which include bees, butterflies and beetles. These are portable glass-topped display boxes that travel throughout Northern California to school classrooms, youth group meetings, festivals, events, museums, hospitals--and more--to help people learn about the exciting world of insect science.
Donors can do so in memory of someone, a place, or a favorite insect. Bond donated $500 in honor of Lynn Kimsey, and Lynn Kimsey donated $500 in memory of the founder, Richard M. Bohart. The donation page and map are at https://bit.ly/3v4MoaJ
The Bohart Museum, currently closed to the public due to COVID-19 precautions, is located in Room 1124 of the Academic Surge Building on Crocker Lane. In addition to its insect collection, which is the seventh largest in North America, the museum houses a live “petting zoo,” comprised of Madagascar hissing cockroaches, stick insects and tarantulas, and a gift shop (now online), stocked with insect-themed t-shirts, hoodies, jewelry, books, posters and other items. Further information is on the website at https://bohart.ucdavis.edu.
- Author: Kathy Keatley Garvey
Professor Jason Bond, the Evert and Marion Schlinger Endowed Chair, UC Davis Department of Entomology and Nematology, is the newly appointed Associate Dean for Research and Outreach for Agricultural Sciences, UC Davis College of Agricultural and Environmental Sciences.
"Jason's position is effective today, Oct 25," announced Dean Helene Dillard. "Jason succeeds Anita Oberbauer, who was reappointed earlier this summer as executive associate dean for the college."
"He has a long history at land-grant institutions, beginning with his Ph.D. in evolutionary systematics and genetics at Virginia Tech and later as a postdoctoral researcher at the Field Museum of Natural History in Chicago," she related.
In an email to fellow members of his department today, Bond wrote: "Like everyone, the events over the last year and half related to the pandemic, like how we communicate science, global change, and the massive social problems these issues are revealing, have really left an impression on me, and consequently feeling like I should be doing more. I have been impressed with Dean Dillard and the group that she has advising her, and am really excited about the opportunity to help facilitate the research, outreach, and DEI (Diversity, Equity, and Inclusion) missions of the College in a meaningful way."
Bond added that he has "no intention of abandoning my research/systematics program, teaching, or other Departmental obligations." He noted that he and his wife, Kristen (who coordinates a nurse training program for Dignity Health) graduated their only daughter this past June from Davis High School and "we are now empty nesters."
Professor Bond joined the UC Davis faculty in 2018 from Auburn University, where he directed the Auburn University Museum of Natural History (2011–2016), and served as professor and chair of the Auburn Department of Biological Sciences (2016–2018). He played a major role in the design and construction of a new state-of-the-art collections facility. He also directed the Alabama Natural Heritage Program, guiding its conservation activities of endangered and threatened species in the Southeast.
Bond was recently named co-editor-in-chief of the journal Insect Systematics and Diversity (ISD), published by the Entomological Society of America, and will serve a four-year term, starting Jan. 1. His credentials also include associate editor of Systematic Biology (2019–present) and editor of New World Mygalomorphae for Zootaxa (2016–present).
In his research, Bond specializes in the evolutionary diversification of terrestrial arthropods, specifically spiders, millipedes, and tenebrionid beetles; and researches the landscape scale genomics of California species, with an emphasis on understanding the impact of global change on biodiversity. (See Bond laboratory.) He is also a principal investigator associated with the California Conservation Genomics Project, a state-funded initiative with a single goal: to produce the most comprehensive, multispecies, genomic dataset ever assembled to help manage regional biodiversity.
Born in Johnson City, Tenn., Jason spent his childhood in Lewisville, N.C., a small town just outside of Winston-Salem. His American roots run deep; his ancestors made munitions for George Washington's army. His father grew up on the campus of East Tennessee State University, where his grandfather served as head of facilities. “The Bond Building” bears his name.
Jason received his bachelor's degree in biological sciences, cum laude, in 1993 from Western Carolina University, Cullowhee, and his master's degree in biology in 1995 from Virginia Polytechnic Institute and State University, Blacksburg. He earned his doctorate in evolutionary systematics and genetics in 1999 from Virginia Tech.
A veteran of the U.S. Army, Bond served for a number of years as a UH-60 Blackhawk helicopter crew chief.
- Author: Kathy Keatley Garvey
The prestigious honor means that the lab, headed by Professor Xiaoling Lu, professor of immunology at Guangxi Medical University (GXMU), is now the central nanobody lab in the province and will receive "more support and expansion," she wrote in an email to Professor Hammock. She expressed her “heartfelt thanks" to Hammock for his "support and encouragement all the time” and added she looks forward to more and closer collaboration.
Lu directs the Nanobody Research Institute of GXMU and also serves as the deputy director of the International Joint Research Center of National Biological Targeting Diagnosis and Therapy.
"Dr. Siliang Duan of Professor Lu's lab was in our lab as a visiting scholar for 15 months (March 9, 2018 until June 1, 2019) to learn nanobody research," said Hammock, who holds a joint appointment with the Department of Entomology and Nematology and the UC Davis Comprehensive Cancer Center. “Their lab is now applying this technology to gene therapy and other cancer biologies."
“This brings up that we all learn from each other internationally and across disciplines,” Hammock said. “The work that Siliang did here really bridged the science done in the mammalian group at Davis developing drugs for treating cancer and cancer pain with the nanobody group. We have extensive experience in nanobodies as diagnostics. While she was here, Siliang bridged the Davis nanobody work with studies on human and companion animal therapeutics at Davis and critically with the cancer therapeutic studies of the Xiaoling Lu group."
Three Papers Published. To date, the Hammock and Lu labs have published three papers together, the first in November 2019:
- “A Nanobody Against Cytotoxic T-Lymphocyte Associated Antigen-4 Increases the Anti-Tumor Effects of Specific CD8(+) T Cells,” published Nov. 1, 2019 in the Journal of Biomedical Technology, an international journal covering research and advanced technologies in the frontiers of biomedical sciences.
- "A Generation of Dual Functional Nanobody-Nanoluciferase Fusion and Its Potential in Bioluminescence Enzyme Immunoassay for Trace Glypican-3 in Serum,” published June 1, 2021 in the journal, Sensors and Actuators B: Chemical, an interdisciplinary journal dedicated to publishing research and development in the field of sensors and biosensors.
- "Nanobody-Based Chimeric Antigen Receptor T-Cells Designed by CRISPR/Cas9 Technology for Solid Tumor Immunotherapy,” published Feb. 25, 2021 in the journal, Signal Transduction and Targeted Therapy.
Nanobodies, used as a research tool in structural, cell, and developmental biology, are the subject of many newly published papers. Lu co-authored a paper March 22, 2021 in the International Journal of Nanomedicine on “Nanobody: A Small Antibody with Big Implications for Tumor Therapeutic Strategy.”
“The development of targeted medicine has greatly expanded treatment options and spurred new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging as a prevalent treatment in recent years,” write Emily Yedam Yang and Khalid Shah of Harvard Medical School and Brigham and Women's Hospital, Boston, in their article, “Nanobodies: Next Generation of Cancer Diagnostics and Therapeutics,” published in the journal, Frontiers in Oncology.
Human Enzyme Discovery. Hammock, internationally recognized for his work in alleviating inflammatory and neuropathic pain in humans and companion animals, co-discovered a human enzyme termed Soluble Epoxide Hydrolase (sEH), a key regulatory enzyme involved in the metabolism of fatty acids. It regulates a new class of natural chemical mediators, which in turn regulates inflammation, blood pressure and pain and in a recent PNAS article showed promise in cancer therapy.
Hammock and his lab have been involved in enzyme research for more than 50 years. Their work was recently cited as one of the key papers in agriculture for the last 50 years. Hammock and his lab introduced immunoassays to environmental chemistry, and they were an early adopter of monoclonal and now nanobody technology.
“The collaboration with Xiaoling and Siliang is wonderful in that the research spanned both the nanobody and therapeutic fields at UC Davis," Hammock said. "For example, we recently used alpaca nanobodies to the sEH to make exceptionally sensitive assays for the enzyme in tiny amounts of human blood. Nanobodies as therapeutics as well as diagnostics was a great contribution to us from Xiaoling and Siliang."
In 2019, Hammock received a $6 million “outstanding investigator” federal grant for his innovative and visionary environmental health research. His pioneering work on inflammation not only extends to alleviating chronic pain, but to targeting inflammation involved in cancer, cardiovascular diseases, diabetes and other health issues.
- Author: Kathy Keatley Garvey
His seminar, to begin at 4:10 p.m., will be in-person and also will be broadcast live on Zoom at https://ucdavis.zoom.us/j/
"Parasitic nematodes are master manipulators of host immunity," Dillman says in his abstract. "Little is known about the identity and function of the cocktail of effectors they release during active infection. We have developed an effector discovery model using entomopathogenic nematodes and fruit flies, which we are using to identify and characterize potent modulators of insect immunity."
Dillman recently received a $1.8 million Outstanding Investigator Award from the National Institutes of Health to study the microscopic parasitic nematodes or "worms" that infect billions of humans and can cause blindness, cognitive issues and sometimes death. He focuses his research on identifying the specific proteins in a nematode's spit or venom that can trick the immune system to ignore its presence. His work on the fruit fly as his model organism could lead to treatments for autoimmune diseases in humans, such as celiac, Crohn's or inflammatory bowel diseases.
Dillman, who joined the UCR faculty in February 2015, is featured in a UC Riverside press release, "Parasitic Worm Venom Evades Human Immune System," posted July 20, 2020 on EurekAlert.
Worms Affect Billions of People. "By some estimates, nearly a quarter of the world's population is infected with various types of microscopic worms, or nematodes, with effects ranging from cognitive impairment and blindness to debilitation, elephantiasis, and death," writer Jules Berstein related. "Examples include hookworm, which thrives in the American South, causing developmental delays and anemia; and pinworms, which commonly infect children and child care workers with an itchy perianal-area rash."
She quoted Dillman: "You can have a person riddled with infection who never realized there's a 2-centimeter-long worm in their eye and thousands of parasites in their blood. The immune system never signaled something was wrong. How is that possible? We know very little about how that works."
Dillman described nematodes as "devastating parasites of humans, capable of modulating our biology in numerous ways, including suppressing our immune systems. The goal of my lab is to understand this modulation and to characterize the chemical pathways that allow it to happen. There's compelling data that parasites could even be used to treat autoimmune disorders such as Crohn's or inflammatory bowel disease. Parasitic worms are just the coolest things you could study because there are so many strange interactions, both positive and negative, that occur between the worms and their hosts."
Why Fruit Flies? Aylin Woodward of Business Insider spotlighted Dillman's work in a news story published Sept. 13, 2020. She wrote that his lab "is looking at 500 or so different types of proteins released by nematodes that infect fruit flies" and quoted Dillman as saying that "flies are cheaper and easier to work with, and the parasites that affect insects release the same proteins as those that infect mammals."
Dillman received his doctorate in 2012 from the California Institute of Technology (Caltech), a private research university in Pasadena, and then served as a postdoctoral fellow at Stanford from 2013 to 2014. He holds a bachelor's degree (2006) from Brigham Young University.
Nematologist Shahid Siddique, assistant professor, coordinates the UC Davis Department of Entomology and Nematology seminars and will introduce Dillman. He may be reached at ssiddique@ucdavis.edu.
- Author: Kathy Keatley Garvey
Sotelo, a researcher in the laboratory of molecular geneticist and physiologist Joanna Chiu, professor and vice chair of the UC Davis Department of Entomology and Nematology, will speak at 4:10 p.m. Plans are to record the seminar for later viewing.
In his abstract, Sotelo relates: “As genome association technologies improve, we have more information regarding the genetic components underlying neurodegenerative and neuropsychiatric disorders such as Alzheimer's, Parkinson's, and schizophrenia. Drosophila melanogaster offers a genetically tractable in vivo system that can be used to perform genetic screens and characterization of genes associated with complex disorders. By combining physiological and behavioral analyses, my work aims to understand the molecular mechanism and neuronal networks involved in some of these conditions.”
“Schizophrenia is a condition that is characterized by its debilitating and poorly understood symptoms," he pointed out. "By studying the genetic component of this disorder, we aim to untangle the mechanisms behind those symptoms. This could potentially help us to develop new and more effective treatments. Using a similar approach would give us insights better understanding of others disorders like Alzheimer's and Parkinson's.”
Said Professor Chiu: “Sergio's exciting thesis research highlights the value of Drosophila as an animal model to study biological processors. To many, it is probably surprising to hear that this tiny insect is constantly used as an animal model to study complex human diseases such as Alzheimer's and Parkinson's. In fact, there are quite a number of similarities between fly and human physiological systems, even in the brain.”
Sotelo joined the Chiu lab as a postdoctoral fellow in the summer of 2020. “Despite the difficult situation brought on by COVID, Sergio is making significant progress in his research on biological rhythms," Chiu said. "He has brought his expertise in neurogenetics, infused the lab with creative energy, and contributed to the training and growth of younger investigators in the lab. Recently, he was named a Pew Latin American Fellow in the Biomedical Sciences, a prestigious award for a well-deserved scientist.”
A native of Puente Alto, Santiago, Chile, Sotelo is one of 10 post-docs from across Latin America—including Argentina, Brazil, Chile, Mexico, Peru, and Uruguay—to receive two years of funding to conduct research. The fellows work under the mentorship of prominent biomedical scientists, including alumni of the Pew Scholars Program in the Biomedical Sciences.
The UC Davis Department of Entomology and Nematology seminars are held on Wednesdays at 4:10 p.m. and include both in-person and virtual lectures. All in-person seminars are held in 122 Briggs Hall, while the virtual seminars are broadcast on Zoom. For more information, contact seminar coordinator Shahid Siddique, at ssiddique@ucdavis.edu.